Progress, Challenges And Opportunities In Fish Vaccine Development
In 2014 the contribution of aquaculture to supply food for human consumption overtook wild-caught fish for the first time. Despite improvements in the aquaculture industry, it has been estimated that as much as 10% of all cultured aquatic animals are lost because of infectious diseases, amounting to...
Published in: | Fish & Shellfish Immunology |
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Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier
2019
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Online Access: | http://hdl.handle.net/1893/29828 https://doi.org/10.1016/j.fsi.2019.04.066 http://dspace.stir.ac.uk/bitstream/1893/29828/1/Progress%20challenges%20and%20opportunities%20in%20fish%20vaccine%20developmentSA.pdf |
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ftunivstirling:oai:dspace.stir.ac.uk:1893/29828 |
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University of Stirling: Stirling Digital Research Repository |
op_collection_id |
ftunivstirling |
language |
English |
topic |
Fish vaccines Fish health management Vaccine administration Vaccine development Mucosal vaccines |
spellingShingle |
Fish vaccines Fish health management Vaccine administration Vaccine development Mucosal vaccines Adams, Alexandra Progress, Challenges And Opportunities In Fish Vaccine Development |
topic_facet |
Fish vaccines Fish health management Vaccine administration Vaccine development Mucosal vaccines |
description |
In 2014 the contribution of aquaculture to supply food for human consumption overtook wild-caught fish for the first time. Despite improvements in the aquaculture industry, it has been estimated that as much as 10% of all cultured aquatic animals are lost because of infectious diseases, amounting to >10 billion USD in losses annually on a global scale. Vaccination to prevent disease is used routinely in finfish aquaculture, especially for Atlantic salmon (Salmo salar), while in a limited capacity (or not at all) in many other fish species due to lack of vaccines, poor performance or cost. There has, nevertheless, been impressive progress in fish vaccine development over the last 4 decades with 24 licenced fish vaccines now commercially available for use in a variety of fish species. These comprise whole killed, peptide subunit, recombinant protein, DNA and live attenuated vaccines. Challenges do, however, still exist as the majority of commercial vaccines are killed whole cell pathogen preparations administered by intraperitoneal injection. This may not be the optimal route to deliver some vaccines, but lack of effective adjuvants and basic knowledge on immune response has hindered progress in the development of mucosal vaccines. The cost of injecting fish may also be prohibitive in some countries leading to disease treatment (e.g. with antibiotics) rather than using preventative measures. It is important that these issues are addressed as the industry continues to grow globally. Exciting opportunities exist for rapid development of fish vaccines in the future, with continued reduction in cost of technologies (e.g. of whole genome sequencing), regulations changing (e.g. DNA vaccines can now authorised in Europe), the introduction of novel antigen expression and delivery systems (such as virus-like particles, VLPs), development of novel adjuvants and advancements in the elucidation of basic mechanisms of mucosal immunity. Development of effective mucosal vaccines and optimisation of their delivery will ... |
author2 |
European Commission Institute of Aquaculture |
format |
Article in Journal/Newspaper |
author |
Adams, Alexandra |
author_facet |
Adams, Alexandra |
author_sort |
Adams, Alexandra |
title |
Progress, Challenges And Opportunities In Fish Vaccine Development |
title_short |
Progress, Challenges And Opportunities In Fish Vaccine Development |
title_full |
Progress, Challenges And Opportunities In Fish Vaccine Development |
title_fullStr |
Progress, Challenges And Opportunities In Fish Vaccine Development |
title_full_unstemmed |
Progress, Challenges And Opportunities In Fish Vaccine Development |
title_sort |
progress, challenges and opportunities in fish vaccine development |
publisher |
Elsevier |
publishDate |
2019 |
url |
http://hdl.handle.net/1893/29828 https://doi.org/10.1016/j.fsi.2019.04.066 http://dspace.stir.ac.uk/bitstream/1893/29828/1/Progress%20challenges%20and%20opportunities%20in%20fish%20vaccine%20developmentSA.pdf |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Adams A (2019) Progress, Challenges And Opportunities In Fish Vaccine Development. Fish and Shellfish Immunology, 90, pp. 210-214. https://doi.org/10.1016/j.fsi.2019.04.066 Targeted disease prophylaxis in European fish farming 311993 http://hdl.handle.net/1893/29828 doi:10.1016/j.fsi.2019.04.066 31039441 WOS:000471085000023 2-s2.0-85065406711 1380286 http://dspace.stir.ac.uk/bitstream/1893/29828/1/Progress%20challenges%20and%20opportunities%20in%20fish%20vaccine%20developmentSA.pdf |
op_rights |
This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Adams A (2019) Progress, Challenges And Opportunities In Fish Vaccine Development. Fish & Shellfish Immunology, 90, pp. 210-214. DOI: https://doi.org/10.1016/j.fsi.2019.04.066 © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-04-28 [Progress challenges and opportunities in fish vaccine developmentSA.pdf] Publisher requires embargo of 12 months after formal publication. |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.fsi.2019.04.066 |
container_title |
Fish & Shellfish Immunology |
container_volume |
90 |
container_start_page |
210 |
op_container_end_page |
214 |
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1766363460961042432 |
spelling |
ftunivstirling:oai:dspace.stir.ac.uk:1893/29828 2023-05-15T15:32:59+02:00 Progress, Challenges And Opportunities In Fish Vaccine Development Adams, Alexandra European Commission Institute of Aquaculture 2019-07 application/pdf http://hdl.handle.net/1893/29828 https://doi.org/10.1016/j.fsi.2019.04.066 http://dspace.stir.ac.uk/bitstream/1893/29828/1/Progress%20challenges%20and%20opportunities%20in%20fish%20vaccine%20developmentSA.pdf en eng Elsevier Adams A (2019) Progress, Challenges And Opportunities In Fish Vaccine Development. Fish and Shellfish Immunology, 90, pp. 210-214. https://doi.org/10.1016/j.fsi.2019.04.066 Targeted disease prophylaxis in European fish farming 311993 http://hdl.handle.net/1893/29828 doi:10.1016/j.fsi.2019.04.066 31039441 WOS:000471085000023 2-s2.0-85065406711 1380286 http://dspace.stir.ac.uk/bitstream/1893/29828/1/Progress%20challenges%20and%20opportunities%20in%20fish%20vaccine%20developmentSA.pdf This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Adams A (2019) Progress, Challenges And Opportunities In Fish Vaccine Development. Fish & Shellfish Immunology, 90, pp. 210-214. DOI: https://doi.org/10.1016/j.fsi.2019.04.066 © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-04-28 [Progress challenges and opportunities in fish vaccine developmentSA.pdf] Publisher requires embargo of 12 months after formal publication. CC-BY-NC-ND Fish vaccines Fish health management Vaccine administration Vaccine development Mucosal vaccines Journal Article AM - Accepted Manuscript 2019 ftunivstirling https://doi.org/10.1016/j.fsi.2019.04.066 2022-06-13T18:42:36Z In 2014 the contribution of aquaculture to supply food for human consumption overtook wild-caught fish for the first time. Despite improvements in the aquaculture industry, it has been estimated that as much as 10% of all cultured aquatic animals are lost because of infectious diseases, amounting to >10 billion USD in losses annually on a global scale. Vaccination to prevent disease is used routinely in finfish aquaculture, especially for Atlantic salmon (Salmo salar), while in a limited capacity (or not at all) in many other fish species due to lack of vaccines, poor performance or cost. There has, nevertheless, been impressive progress in fish vaccine development over the last 4 decades with 24 licenced fish vaccines now commercially available for use in a variety of fish species. These comprise whole killed, peptide subunit, recombinant protein, DNA and live attenuated vaccines. Challenges do, however, still exist as the majority of commercial vaccines are killed whole cell pathogen preparations administered by intraperitoneal injection. This may not be the optimal route to deliver some vaccines, but lack of effective adjuvants and basic knowledge on immune response has hindered progress in the development of mucosal vaccines. The cost of injecting fish may also be prohibitive in some countries leading to disease treatment (e.g. with antibiotics) rather than using preventative measures. It is important that these issues are addressed as the industry continues to grow globally. Exciting opportunities exist for rapid development of fish vaccines in the future, with continued reduction in cost of technologies (e.g. of whole genome sequencing), regulations changing (e.g. DNA vaccines can now authorised in Europe), the introduction of novel antigen expression and delivery systems (such as virus-like particles, VLPs), development of novel adjuvants and advancements in the elucidation of basic mechanisms of mucosal immunity. Development of effective mucosal vaccines and optimisation of their delivery will ... Article in Journal/Newspaper Atlantic salmon Salmo salar University of Stirling: Stirling Digital Research Repository Fish & Shellfish Immunology 90 210 214 |