Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure ‘biomarker’ signals and induction of inflammatory, innate immune and apoptotic pathways

• Published in: Aquatic Toxicology
• Main Authors: Leaver, Michael, Diab, Amer, Boukouvala, Evridiki, Williams, Tim D, Chipman, James Kevin, Moffat, Colin F, Robinson, Craig D, George, Stephen
• Other Authors: Institute of Aquaculture, National Agricultural Research Foundation, University of Birmingham, Scottish Government - Enterprise, Environment & Digital - Marine Scotland, orcid:0000-0002-3155-0844
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2010
• Subjects: ecotoxicolgy; microarray; flounder; sediment; Diablo; cyp1A; Lipoproteins Fish; Fishes Feeding and feeds; Dietary supplements; Atlantic salmon
• Online Access: http://hdl.handle.net/1893/2051; https://doi.org/10.1016/j.aquatox.2009.10.025; http://www.sciencedirect.com/science/journal/0166445X; http://dspace.stir.ac.uk/bitstream/1893/2051/1/LeaverAqTox2009TextRevisedforSTORRE.pdf

The effects of chronic long term exposure to multiply-polluted environments on fish are not well understood, but environmental surveys suggest that such exposure may cause a variety of pathologies, including cancers. Transcriptomic profiling has recently been used to assess gene expression in Europe...