Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals
Pharmaceuticals are pseudopersistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 ± 7.98, and Carbamazepine: 7.85 ± 0.13 μg·L−1 for 5 days. After Acetaminophen treatment...
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Molecular & Cellular Proteomics
2018
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ftunivsevillair:oai:idus.us.es:11441/80129 2023-05-15T15:30:47+02:00 Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals Hampel, Miriam Alonso, Esteban Aparicio Gómez, Irene Santos Morcillo, Juan Luis Leaver, Michael Universidad de Sevilla. Departamento de Química Analítica Universidad de Sevilla. FQM344: Análisis Químico Industrial y Medioambiental European Union (UE). FP6 2018-11-13T18:56:32Z application/pdf https://idus.us.es/xmlui/handle//11441/80129 eng eng Molecular & Cellular Proteomics Molecular and Cellular Proteomics, 14 (2), 371-381. https://eprints.ucm.es/43057/1/Aparicio.%202015.%20Hepatic%20proteome%20analysis%20of%20Atlantic%20salmon%20%28Salmo%20salar%29%20after%20exposure%20to%20environmental%20concentrations%20of%20human%20pharmaceuticals.pdf Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess CC-BY-NC-ND info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2018 ftunivsevillair 2019-12-24T09:53:45Z Pharmaceuticals are pseudopersistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 ± 7.98, and Carbamazepine: 7.85 ± 0.13 μg·L−1 for 5 days. After Acetaminophen treatment, 19 proteins were differently expressed, of which 11 were significant with respect to the control group (eight up-regulated and three down-regulated). After Atenolol treatment, seven differently expressed proteins were obtained in comparison with the control, of which six could be identified (four up-regulated and two down-regulated). Carbamazepine exposure resulted in 15 differently expressed proteins compared with the control, with 10 of them identified (seven up-regulated and three down-regulated). Out of these, three features were common between Acetaminophen and Carbamazepine and one between Carbamazepine and Atenolol. One feature was common across all treatments. Principal component analysis and heat map clustering showed a clear grouping of the variability caused by the applied treatments. The obtained data suggest (1) that exposure to environmentally relevant concentrations of the pharmaceuticals alters the hepatic protein expression profile of the Atlantic salmon; and (2) the existence of treatment specific processes that may be useful for biomarker development. Dr Alberto Pascual Bravo, Raquel Gómez Díaz, y Dr Antonio Romero Ruíz del Instituto de Biomedicina (IBIS-CSIC) en Sevilla Marie Curie (Proposal N° EIF-039691-SALMONPHARM, FP6-2005-Mobility-5) Article in Journal/Newspaper Atlantic salmon Salmo salar idUS - Deposito de Investigación Universidad de Sevilla Romero ENVELOPE(-57.350,-57.350,-63.283,-63.283) |
institution |
Open Polar |
collection |
idUS - Deposito de Investigación Universidad de Sevilla |
op_collection_id |
ftunivsevillair |
language |
English |
description |
Pharmaceuticals are pseudopersistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 ± 7.98, and Carbamazepine: 7.85 ± 0.13 μg·L−1 for 5 days. After Acetaminophen treatment, 19 proteins were differently expressed, of which 11 were significant with respect to the control group (eight up-regulated and three down-regulated). After Atenolol treatment, seven differently expressed proteins were obtained in comparison with the control, of which six could be identified (four up-regulated and two down-regulated). Carbamazepine exposure resulted in 15 differently expressed proteins compared with the control, with 10 of them identified (seven up-regulated and three down-regulated). Out of these, three features were common between Acetaminophen and Carbamazepine and one between Carbamazepine and Atenolol. One feature was common across all treatments. Principal component analysis and heat map clustering showed a clear grouping of the variability caused by the applied treatments. The obtained data suggest (1) that exposure to environmentally relevant concentrations of the pharmaceuticals alters the hepatic protein expression profile of the Atlantic salmon; and (2) the existence of treatment specific processes that may be useful for biomarker development. Dr Alberto Pascual Bravo, Raquel Gómez Díaz, y Dr Antonio Romero Ruíz del Instituto de Biomedicina (IBIS-CSIC) en Sevilla Marie Curie (Proposal N° EIF-039691-SALMONPHARM, FP6-2005-Mobility-5) |
author2 |
Universidad de Sevilla. Departamento de Química Analítica Universidad de Sevilla. FQM344: Análisis Químico Industrial y Medioambiental European Union (UE). FP6 |
format |
Article in Journal/Newspaper |
author |
Hampel, Miriam Alonso, Esteban Aparicio Gómez, Irene Santos Morcillo, Juan Luis Leaver, Michael |
spellingShingle |
Hampel, Miriam Alonso, Esteban Aparicio Gómez, Irene Santos Morcillo, Juan Luis Leaver, Michael Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
author_facet |
Hampel, Miriam Alonso, Esteban Aparicio Gómez, Irene Santos Morcillo, Juan Luis Leaver, Michael |
author_sort |
Hampel, Miriam |
title |
Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
title_short |
Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
title_full |
Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
title_fullStr |
Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
title_full_unstemmed |
Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
title_sort |
hepatic proteome analysis of atlantic salmon (salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
publisher |
Molecular & Cellular Proteomics |
publishDate |
2018 |
url |
https://idus.us.es/xmlui/handle//11441/80129 |
long_lat |
ENVELOPE(-57.350,-57.350,-63.283,-63.283) |
geographic |
Romero |
geographic_facet |
Romero |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Molecular and Cellular Proteomics, 14 (2), 371-381. https://eprints.ucm.es/43057/1/Aparicio.%202015.%20Hepatic%20proteome%20analysis%20of%20Atlantic%20salmon%20%28Salmo%20salar%29%20after%20exposure%20to%20environmental%20concentrations%20of%20human%20pharmaceuticals.pdf |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY-NC-ND |
_version_ |
1766361239467851776 |