Standardization of functional and regulatory genomic annotation technologies in turbot (Scophthalmus maximus): Applications to improve fish production

• Main Author: Aramburu González, Óscar
• Other Authors: Bouza Fernández, María Carmen, Martínez Portela, Paulino, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Básica e Aplicada en Ciencias Veterinarias
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Subjects: Rodaballo; Xenómica; Resposta inmune; Regulómica; 240108 Genética animal; 310502 Piscicultura; 310902 Genética; Scophthalmus maximus; Turbot
• Online Access: http://hdl.handle.net/10347/34444

Aquaculture production represents an important source of food and employment, turning the sector into a focal point for economic investment to improve production while adressing its core problems, such as diseases. The advances in genomic technologies have opened the door to the disection of the genetic basis and variation that underlies disease resiliance and other productive traits. In this thesis, maps of functional, regulatory and structural elements in the turbot genome were updated and generated. This thesis provides evidence of marks of selection left in the turbot genome throughout its process of domestication and lays out new targets for selection programs by opening the door to the unexplored regulatory elements throught the incorporation of ATAC-Seq and ChIP-Seq technologies.