Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis
Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastating diseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic d...
Published in: | Frontiers in Genetics |
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Language: | English |
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Online Access: | http://hdl.handle.net/10347/20988 https://doi.org/10.3389/fgene.2019.00026 |
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ftunivsantcomp:oai:minerva.usc.es:10347/20988 |
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Open Polar |
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Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
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language |
English |
topic |
Scophthalmus maximus Pathogenesis Histopathology Transcriptomics |
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Scophthalmus maximus Pathogenesis Histopathology Transcriptomics Ronza, Paolo Robledo Sánchez, Diego Bermúdez Pose, Roberto Losada García, Ana Paula Gómez Pardo, María Belén Martínez Portela, Paulino Quiroga Berdeal, María Isabel Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
topic_facet |
Scophthalmus maximus Pathogenesis Histopathology Transcriptomics |
description |
Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastating diseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortality rates usually reaching 100%. To date, no effective treatment exists and there are different unknown issues concerning its pathogenesis. The gross and microscopic lesions associated to enteromyxosis have been thoroughly described, and several morphopathological studies have been carried out to elucidate the mechanisms of this host-parasite interaction. More recently, efforts have been focused on a multidisciplinary approach, combining histopathology and transcriptome analysis, which has provided significant advances in the understanding of the pathogenesis of this parasitosis. RNASeq technology was applied at early and advanced stages of the disease on fishes histologically evaluated and classified based on their lesional degree. In the same way, the transcriptomic data were analyzed in relation to the morphopathological picture and the course of the disease. In this paper, a comprehensive review of turbot enteromyxosis is presented, starting from the disease description up to the most novel information extracted by an integrated approach on the infection mechanisms and host response. Further, we discuss ongoing strategies toward a full understanding of host-pathogen interaction and the identification of suitable biomarkers for early diagnosis and disease management strategies. This work was supported by the European Regional Development Fund (ERDF) together with the Spanish Ministry of Economy, Industry and Competitiveness through the projects AGL2015–67039–C3–1–R and AGL2015–67039–C3–3–R. DR was supported by a Newton International Fellowship from The Royal Society (NF160037) SI |
author2 |
Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física |
format |
Article in Journal/Newspaper |
author |
Ronza, Paolo Robledo Sánchez, Diego Bermúdez Pose, Roberto Losada García, Ana Paula Gómez Pardo, María Belén Martínez Portela, Paulino Quiroga Berdeal, María Isabel |
author_facet |
Ronza, Paolo Robledo Sánchez, Diego Bermúdez Pose, Roberto Losada García, Ana Paula Gómez Pardo, María Belén Martínez Portela, Paulino Quiroga Berdeal, María Isabel |
author_sort |
Ronza, Paolo |
title |
Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
title_short |
Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
title_full |
Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
title_fullStr |
Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
title_full_unstemmed |
Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis |
title_sort |
integrating genomic and morphological approaches in fish pathology research: the case of turbot (scophthalmus maximus) enteromyxosis |
publisher |
Frontiers Media |
url |
http://hdl.handle.net/10347/20988 https://doi.org/10.3389/fgene.2019.00026 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
https://doi.org/10.3389/fgene.2019.00026 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015–67039–C3–1–R/ES/BUSQUEDA DE HERRAMIENTAS DE DIAGNOSTICO PRECOZ Y DETECCION DE BIOMARCADORES DE SALUD/ENFERMEDAD INTESTINAL EN RODABALLO: ENTEROMIXOSIS COMO MODELO DE ESTUDIO info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015–67039–C3–3–R/ES/ENTEROMYXOSIS EN RODABALLO: DIAGNOSTICO PRECOZ Y ANALISIS DE LOS CAMBIOS EN LA FISIOLOGIA DEL TUBO DIGESTIVO MEDIANTE ESTUDIO DE EXPRESION GENICA CON RNA-SEQ Ronza P, Robledo D, Bermúdez R, Losada AP, Pardo BG, Martínez P and Quiroga MI (2019) Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis. Front. Genet. 10:26. doi:10.3389/fgene.2019.00026 http://hdl.handle.net/10347/20988 doi:10.3389/fgene.2019.00026 1664-8021 |
op_rights |
Copyright © 2019 Ronza, Robledo, Bermúdez, Losada, Pardo, Martínez and Quiroga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fgene.2019.00026 |
container_title |
Frontiers in Genetics |
container_volume |
10 |
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1772819523989143552 |
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ftunivsantcomp:oai:minerva.usc.es:10347/20988 2023-07-30T04:06:40+02:00 Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis Ronza, Paolo Robledo Sánchez, Diego Bermúdez Pose, Roberto Losada García, Ana Paula Gómez Pardo, María Belén Martínez Portela, Paulino Quiroga Berdeal, María Isabel Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física application/pdf http://hdl.handle.net/10347/20988 https://doi.org/10.3389/fgene.2019.00026 eng eng Frontiers Media https://doi.org/10.3389/fgene.2019.00026 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015–67039–C3–1–R/ES/BUSQUEDA DE HERRAMIENTAS DE DIAGNOSTICO PRECOZ Y DETECCION DE BIOMARCADORES DE SALUD/ENFERMEDAD INTESTINAL EN RODABALLO: ENTEROMIXOSIS COMO MODELO DE ESTUDIO info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015–67039–C3–3–R/ES/ENTEROMYXOSIS EN RODABALLO: DIAGNOSTICO PRECOZ Y ANALISIS DE LOS CAMBIOS EN LA FISIOLOGIA DEL TUBO DIGESTIVO MEDIANTE ESTUDIO DE EXPRESION GENICA CON RNA-SEQ Ronza P, Robledo D, Bermúdez R, Losada AP, Pardo BG, Martínez P and Quiroga MI (2019) Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis. Front. Genet. 10:26. doi:10.3389/fgene.2019.00026 http://hdl.handle.net/10347/20988 doi:10.3389/fgene.2019.00026 1664-8021 Copyright © 2019 Ronza, Robledo, Bermúdez, Losada, Pardo, Martínez and Quiroga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Scophthalmus maximus Pathogenesis Histopathology Transcriptomics info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion ftunivsantcomp https://doi.org/10.3389/fgene.2019.00026 2023-07-11T23:26:11Z Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastating diseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortality rates usually reaching 100%. To date, no effective treatment exists and there are different unknown issues concerning its pathogenesis. The gross and microscopic lesions associated to enteromyxosis have been thoroughly described, and several morphopathological studies have been carried out to elucidate the mechanisms of this host-parasite interaction. More recently, efforts have been focused on a multidisciplinary approach, combining histopathology and transcriptome analysis, which has provided significant advances in the understanding of the pathogenesis of this parasitosis. RNASeq technology was applied at early and advanced stages of the disease on fishes histologically evaluated and classified based on their lesional degree. In the same way, the transcriptomic data were analyzed in relation to the morphopathological picture and the course of the disease. In this paper, a comprehensive review of turbot enteromyxosis is presented, starting from the disease description up to the most novel information extracted by an integrated approach on the infection mechanisms and host response. Further, we discuss ongoing strategies toward a full understanding of host-pathogen interaction and the identification of suitable biomarkers for early diagnosis and disease management strategies. This work was supported by the European Regional Development Fund (ERDF) together with the Spanish Ministry of Economy, Industry and Competitiveness through the projects AGL2015–67039–C3–1–R and AGL2015–67039–C3–3–R. DR was supported by a Newton International Fellowship from The Royal Society (NF160037) SI Article in Journal/Newspaper Scophthalmus maximus Turbot Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) Frontiers in Genetics 10 |