Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus)
Although turbot aquaculture is well established, several pathogens can affect its health status, causing important economic losses. VHSV is one of the main threats in turbot farms due to the absence of treatments and vaccines for VHSV. The first goal of this thesis was to increase the information av...
Main Author: | |
---|---|
Other Authors: | , , , , , |
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Subjects: | |
Online Access: | http://hdl.handle.net/10347/15834 |
id |
ftunivsantcomp:oai:minerva.usc.es:10347/15834 |
---|---|
record_format |
openpolar |
spelling |
ftunivsantcomp:oai:minerva.usc.es:10347/15834 2023-05-15T18:15:48+02:00 Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) Pereiro González, Patricia Novoa García, Beatriz Figueras Huerta, Antonio Lemos Ramos, Manuel Luis Universidade de Santiago de Compostela. Facultade de Bioloxía Universidade de Santiago de Compostela. Instituto de Acuicultura Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía application/pdf http://hdl.handle.net/10347/15834 eng eng http://hdl.handle.net/10347/15834 Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl info:eu-repo/semantics/openAccess CC-BY-NC-ND Rodaballo VHSV Respuesta Inmune Interferones Materias::Investigación::31 Ciencias agrarias::3109 Ciencias veterinarias::310903 Inmunología Materias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240108 Genética animal info:eu-repo/semantics/doctoralThesis ftunivsantcomp 2022-11-16T00:24:00Z Although turbot aquaculture is well established, several pathogens can affect its health status, causing important economic losses. VHSV is one of the main threats in turbot farms due to the absence of treatments and vaccines for VHSV. The first goal of this thesis was to increase the information available in public databases regarding the transcriptome sequences associated with the antiviral immune response of turbot. A microarray highly enriched in antiviral sequences was constructed using this information. This allowed us to conduct a broad transcriptome analysis of the response to VHSV infection and evaluate the activity of a DNA vaccine against VHSV. This information led us to focus our attention on certain molecules or processes affected by the vaccine/infection. This was the case for two type I interferons (IFNs), which were characterized and studied for the first time in turbot. In order to complete our knowledge about the IFNs, we also sought to investigate the role of the type II IFN (IFN-gamma). Doctoral or Postdoctoral Thesis Scophthalmus maximus Turbot Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
institution |
Open Polar |
collection |
Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
op_collection_id |
ftunivsantcomp |
language |
English |
topic |
Rodaballo VHSV Respuesta Inmune Interferones Materias::Investigación::31 Ciencias agrarias::3109 Ciencias veterinarias::310903 Inmunología Materias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240108 Genética animal |
spellingShingle |
Rodaballo VHSV Respuesta Inmune Interferones Materias::Investigación::31 Ciencias agrarias::3109 Ciencias veterinarias::310903 Inmunología Materias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240108 Genética animal Pereiro González, Patricia Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
topic_facet |
Rodaballo VHSV Respuesta Inmune Interferones Materias::Investigación::31 Ciencias agrarias::3109 Ciencias veterinarias::310903 Inmunología Materias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240108 Genética animal |
description |
Although turbot aquaculture is well established, several pathogens can affect its health status, causing important economic losses. VHSV is one of the main threats in turbot farms due to the absence of treatments and vaccines for VHSV. The first goal of this thesis was to increase the information available in public databases regarding the transcriptome sequences associated with the antiviral immune response of turbot. A microarray highly enriched in antiviral sequences was constructed using this information. This allowed us to conduct a broad transcriptome analysis of the response to VHSV infection and evaluate the activity of a DNA vaccine against VHSV. This information led us to focus our attention on certain molecules or processes affected by the vaccine/infection. This was the case for two type I interferons (IFNs), which were characterized and studied for the first time in turbot. In order to complete our knowledge about the IFNs, we also sought to investigate the role of the type II IFN (IFN-gamma). |
author2 |
Novoa García, Beatriz Figueras Huerta, Antonio Lemos Ramos, Manuel Luis Universidade de Santiago de Compostela. Facultade de Bioloxía Universidade de Santiago de Compostela. Instituto de Acuicultura Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía |
format |
Doctoral or Postdoctoral Thesis |
author |
Pereiro González, Patricia |
author_facet |
Pereiro González, Patricia |
author_sort |
Pereiro González, Patricia |
title |
Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
title_short |
Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
title_full |
Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
title_fullStr |
Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
title_full_unstemmed |
Advances in the knowledge of the antiviral immune response and resistance to Viral Haemorrhagic Septicaemia Virus (VHSV) in turbot (Scophthalmus maximus) |
title_sort |
advances in the knowledge of the antiviral immune response and resistance to viral haemorrhagic septicaemia virus (vhsv) in turbot (scophthalmus maximus) |
url |
http://hdl.handle.net/10347/15834 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
http://hdl.handle.net/10347/15834 |
op_rights |
Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY-NC-ND |
_version_ |
1766189034372071424 |