Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study
Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metab...
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ftunivsalento:oai:iris.unisalento.it:11587/490404 2024-04-21T07:52:31+00:00 Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Anas Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Ana Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele 2023 ELETTRONICO https://hdl.handle.net/11587/490404 https://doi.org/10.3390/ijms24098459 https://www.mdpi.com/1422-0067/24/9/8459 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000987714800001 volume:24 numberofpages:16 journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES https://hdl.handle.net/11587/490404 doi:10.3390/ijms24098459 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159306877 https://www.mdpi.com/1422-0067/24/9/8459 info:eu-repo/semantics/openAccess Antarctica Concordia base NMR adaptation hypoxia metabolomics winter over info:eu-repo/semantics/article 2023 ftunivsalento https://doi.org/10.3390/ijms24098459 2024-03-28T01:38:29Z Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metabolic profiles of the serum samples were analyzed using NMR spectroscopy, with principal components analysis (PCA) followed by partial least squares and orthogonal partial least squares discriminant analyses (PLS-DA and OPLS-DA) used as supervised classification methods. Multivariate data analyses clearly highlighted an adaptation period characterized by an increase in the levels of circulating glutamine and lipids, mobilized to supply the body energy needs. At the same time, a reduction in the circulating levels of glutamate and N-acetyl glycoproteins, stress condition indicators, and proinflammatory markers were also found in the NMR data investigation. Subsequent pathway analysis showed possible perturbations in metabolic processes, potentially related to the physiological adaptation, predominantly found by comparing the baseline (at sea level, before mission onset), the base arrival, and the mission ending collected values. Article in Journal/Newspaper Antarc* Antarctic Antarctica Università del Salento: CINECA IRIS International Journal of Molecular Sciences 24 9 8459 |
institution |
Open Polar |
collection |
Università del Salento: CINECA IRIS |
op_collection_id |
ftunivsalento |
language |
English |
topic |
Antarctica Concordia base NMR adaptation hypoxia metabolomics winter over |
spellingShingle |
Antarctica Concordia base NMR adaptation hypoxia metabolomics winter over Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Anas Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
topic_facet |
Antarctica Concordia base NMR adaptation hypoxia metabolomics winter over |
description |
Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metabolic profiles of the serum samples were analyzed using NMR spectroscopy, with principal components analysis (PCA) followed by partial least squares and orthogonal partial least squares discriminant analyses (PLS-DA and OPLS-DA) used as supervised classification methods. Multivariate data analyses clearly highlighted an adaptation period characterized by an increase in the levels of circulating glutamine and lipids, mobilized to supply the body energy needs. At the same time, a reduction in the circulating levels of glutamate and N-acetyl glycoproteins, stress condition indicators, and proinflammatory markers were also found in the NMR data investigation. Subsequent pathway analysis showed possible perturbations in metabolic processes, potentially related to the physiological adaptation, predominantly found by comparing the baseline (at sea level, before mission onset), the base arrival, and the mission ending collected values. |
author2 |
Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Ana Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele |
format |
Article in Journal/Newspaper |
author |
Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Anas Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele |
author_facet |
Del Coco, Laura Greco, Marco Inguscio, Alessandra Munir, Anas Danieli, Antonio Cossa, Luca Musarò, Debora Coscia, Maria Rosaria Fanizzi, Francesco Paolo Maffia, Michele |
author_sort |
Del Coco, Laura |
title |
Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
title_short |
Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
title_full |
Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
title_fullStr |
Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
title_full_unstemmed |
Blood Metabolite Profiling of Antarctic Expedition Members: An 1H NMR Spectroscopy-Based Study |
title_sort |
blood metabolite profiling of antarctic expedition members: an 1h nmr spectroscopy-based study |
publishDate |
2023 |
url |
https://hdl.handle.net/11587/490404 https://doi.org/10.3390/ijms24098459 https://www.mdpi.com/1422-0067/24/9/8459 |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000987714800001 volume:24 numberofpages:16 journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES https://hdl.handle.net/11587/490404 doi:10.3390/ijms24098459 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159306877 https://www.mdpi.com/1422-0067/24/9/8459 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/ijms24098459 |
container_title |
International Journal of Molecular Sciences |
container_volume |
24 |
container_issue |
9 |
container_start_page |
8459 |
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1796935741130932224 |