In vivo implant of a new generation of neural collagen-based guides
The use of a tubular construct (termed conduit) to reconnect the proximal and distal stumps of a transected nerve, and induce regeneration of the lost nerve trunk, has been the subject of a large number of investigations. While the presence of a conduit between the transected stumps is sufficient to...
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European Society for Biomaterials
2009
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ftunivsalento:oai:iris.unisalento.it:11587/408246 2024-02-11T10:08:24+01:00 In vivo implant of a new generation of neural collagen-based guides Piccinno, A. Quattrini, A. SALVATORE, LUCA SANNINO, Alessandro Piccinno, A. Salvatore, Luca Quattrini, A. Sannino, Alessandro 2009 ELETTRONICO http://hdl.handle.net/11587/408246 eng eng European Society for Biomaterials country:FRA place:Strasbourg ispartofbook:Abstract Book of the 22nd European Conference on Biomaterials 22nd European Conference on Biomaterials (ESB) firstpage:1 lastpage:1 http://hdl.handle.net/11587/408246 Nerve-guide micropatterned porosity collagen info:eu-repo/semantics/conferenceObject 2009 ftunivsalento 2024-01-17T17:39:26Z The use of a tubular construct (termed conduit) to reconnect the proximal and distal stumps of a transected nerve, and induce regeneration of the lost nerve trunk, has been the subject of a large number of investigations. While the presence of a conduit between the transected stumps is sufficient to induce regeneration, the microstructural, mechanical and compositional features of the tubular construct itself, and of any material inserted within the tube lumen, have been observed to significantly affect the quality of regeneration. An ideal conduit should protect the site of injury from the infiltration of surrounding tissues, at the same time retaining a certain degree of porosity to allow diffusion of soluble factors (SFs) through the tube wall. Moreover, it should affect the migration and organization of myofibroblasts, which are responsible for the undesired synthesis of scar tissue. The conduit should also provide adequate mechanical strength and flexibility to support the regenerating nerve fibers, and should be biocompatible and biodegradable.Pioneering studies on peripheral nerve regeneration made extensive use of biodurable conduits, such as silicone tubes and, recently, a wide variety of biodegradable materials, including synthetic and natural polymers, and different conduit geometries have been examined. Collagen has been identified as one of the most promising materials for the production of conduits due to its biocompatibility and the observed enhanced cell attachment within collagen scaffolds. A new type of neural guide based on highly engineered collagenic porous matrices has been developed and patented. They are characterized by the presence of a radially micropatterned porosity, obtained acting on the thermodynamic of crystallization and playing with a sedimentation effect promoted by a spinning device. A full in vivo preclinical study has been performed and the approval from the ethical committee of the San Raffaele Hospital has been obtained to perform an human study on the regeneration of the ... Conference Object SCAR Università del Salento: CINECA IRIS |
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Università del Salento: CINECA IRIS |
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ftunivsalento |
language |
English |
topic |
Nerve-guide micropatterned porosity collagen |
spellingShingle |
Nerve-guide micropatterned porosity collagen Piccinno, A. Quattrini, A. SALVATORE, LUCA SANNINO, Alessandro In vivo implant of a new generation of neural collagen-based guides |
topic_facet |
Nerve-guide micropatterned porosity collagen |
description |
The use of a tubular construct (termed conduit) to reconnect the proximal and distal stumps of a transected nerve, and induce regeneration of the lost nerve trunk, has been the subject of a large number of investigations. While the presence of a conduit between the transected stumps is sufficient to induce regeneration, the microstructural, mechanical and compositional features of the tubular construct itself, and of any material inserted within the tube lumen, have been observed to significantly affect the quality of regeneration. An ideal conduit should protect the site of injury from the infiltration of surrounding tissues, at the same time retaining a certain degree of porosity to allow diffusion of soluble factors (SFs) through the tube wall. Moreover, it should affect the migration and organization of myofibroblasts, which are responsible for the undesired synthesis of scar tissue. The conduit should also provide adequate mechanical strength and flexibility to support the regenerating nerve fibers, and should be biocompatible and biodegradable.Pioneering studies on peripheral nerve regeneration made extensive use of biodurable conduits, such as silicone tubes and, recently, a wide variety of biodegradable materials, including synthetic and natural polymers, and different conduit geometries have been examined. Collagen has been identified as one of the most promising materials for the production of conduits due to its biocompatibility and the observed enhanced cell attachment within collagen scaffolds. A new type of neural guide based on highly engineered collagenic porous matrices has been developed and patented. They are characterized by the presence of a radially micropatterned porosity, obtained acting on the thermodynamic of crystallization and playing with a sedimentation effect promoted by a spinning device. A full in vivo preclinical study has been performed and the approval from the ethical committee of the San Raffaele Hospital has been obtained to perform an human study on the regeneration of the ... |
author2 |
Piccinno, A. Salvatore, Luca Quattrini, A. Sannino, Alessandro |
format |
Conference Object |
author |
Piccinno, A. Quattrini, A. SALVATORE, LUCA SANNINO, Alessandro |
author_facet |
Piccinno, A. Quattrini, A. SALVATORE, LUCA SANNINO, Alessandro |
author_sort |
Piccinno, A. |
title |
In vivo implant of a new generation of neural collagen-based guides |
title_short |
In vivo implant of a new generation of neural collagen-based guides |
title_full |
In vivo implant of a new generation of neural collagen-based guides |
title_fullStr |
In vivo implant of a new generation of neural collagen-based guides |
title_full_unstemmed |
In vivo implant of a new generation of neural collagen-based guides |
title_sort |
in vivo implant of a new generation of neural collagen-based guides |
publisher |
European Society for Biomaterials |
publishDate |
2009 |
url |
http://hdl.handle.net/11587/408246 |
genre |
SCAR |
genre_facet |
SCAR |
op_relation |
ispartofbook:Abstract Book of the 22nd European Conference on Biomaterials 22nd European Conference on Biomaterials (ESB) firstpage:1 lastpage:1 http://hdl.handle.net/11587/408246 |
_version_ |
1790607712468336640 |