Heterozygosity and lungworm burden in harbour seals (Phoca vitulina)
In several studies, heterozygosity measured at around 10 microsatellite markers correlates with parasite load. Usually the effect size is small, but while this may reflect reality, it may also be possible that too few markers are used or the measure of fitness contains too much error to reveal what...
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ftunivrotterdam:oai:repub.eur.nl:29120 2023-07-16T03:58:53+02:00 Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) Rijks, J.M. (Jolianne) Hoffman, J.I. (Joseph) Kuiken, T. (Thijs) Osterhaus, A.D.M.E. (Albert) Amos, W. 2008-06-23 http://repub.eur.nl/pub/29120 https://doi.org/10.1038/hdy.2008.18 en eng http://repub.eur.nl/pub/29120 doi:10.1038/hdy.2008.18 urn:hdl:1765/29120 info:eu-repo/semantics/openAccess Heredity vol. 100 no. 6, pp. 587-593 Harbour seal (Phoca vitulina) Heterozygosity-fitness correlation (HFC) Lungworm burden Otostrongylus circumlitus Parafilaroides gymnurus info:eu-repo/semantics/article 2008 ftunivrotterdam https://doi.org/10.1038/hdy.2008.18 2023-06-26T22:14:55Z In several studies, heterozygosity measured at around 10 microsatellite markers correlates with parasite load. Usually the effect size is small, but while this may reflect reality, it may also be possible that too few markers are used or the measure of fitness contains too much error to reveal what is actually a much stronger underlying effect. Here, we analysed over 200 stranded harbour seals (Phoca vitulina) for an association between lungworm burden and heterozygosity, conducting thorough necropsies on the seals and genotyping the samples obtained for 27 microsatellites. We found that homozygosity predicts higher worm burdens, but only in young animals, where the worms have the greatest impact on fitness. Testing each locus separately, we found that a significant majority reveal a weak but similar trend for heterozygosity to be protective against high lungworm burden, suggesting a genome-wide effect, that is, inbreeding. This conclusion is supported by the fact that heterozygosity is correlated among markers in young animals but not in otherwise equivalent older ones. Taken as a whole, our results support the notion that homozygosity increases susceptibility to parasitic infection and suggest that parasites can be effective in removing inbred individuals from the population. Article in Journal/Newspaper harbour seal Phoca vitulina RePub - Publications from Erasmus University, Rotterdam Heredity 100 6 587 593 |
institution |
Open Polar |
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RePub - Publications from Erasmus University, Rotterdam |
op_collection_id |
ftunivrotterdam |
language |
English |
topic |
Harbour seal (Phoca vitulina) Heterozygosity-fitness correlation (HFC) Lungworm burden Otostrongylus circumlitus Parafilaroides gymnurus |
spellingShingle |
Harbour seal (Phoca vitulina) Heterozygosity-fitness correlation (HFC) Lungworm burden Otostrongylus circumlitus Parafilaroides gymnurus Rijks, J.M. (Jolianne) Hoffman, J.I. (Joseph) Kuiken, T. (Thijs) Osterhaus, A.D.M.E. (Albert) Amos, W. Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
topic_facet |
Harbour seal (Phoca vitulina) Heterozygosity-fitness correlation (HFC) Lungworm burden Otostrongylus circumlitus Parafilaroides gymnurus |
description |
In several studies, heterozygosity measured at around 10 microsatellite markers correlates with parasite load. Usually the effect size is small, but while this may reflect reality, it may also be possible that too few markers are used or the measure of fitness contains too much error to reveal what is actually a much stronger underlying effect. Here, we analysed over 200 stranded harbour seals (Phoca vitulina) for an association between lungworm burden and heterozygosity, conducting thorough necropsies on the seals and genotyping the samples obtained for 27 microsatellites. We found that homozygosity predicts higher worm burdens, but only in young animals, where the worms have the greatest impact on fitness. Testing each locus separately, we found that a significant majority reveal a weak but similar trend for heterozygosity to be protective against high lungworm burden, suggesting a genome-wide effect, that is, inbreeding. This conclusion is supported by the fact that heterozygosity is correlated among markers in young animals but not in otherwise equivalent older ones. Taken as a whole, our results support the notion that homozygosity increases susceptibility to parasitic infection and suggest that parasites can be effective in removing inbred individuals from the population. |
format |
Article in Journal/Newspaper |
author |
Rijks, J.M. (Jolianne) Hoffman, J.I. (Joseph) Kuiken, T. (Thijs) Osterhaus, A.D.M.E. (Albert) Amos, W. |
author_facet |
Rijks, J.M. (Jolianne) Hoffman, J.I. (Joseph) Kuiken, T. (Thijs) Osterhaus, A.D.M.E. (Albert) Amos, W. |
author_sort |
Rijks, J.M. (Jolianne) |
title |
Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
title_short |
Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
title_full |
Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
title_fullStr |
Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
title_full_unstemmed |
Heterozygosity and lungworm burden in harbour seals (Phoca vitulina) |
title_sort |
heterozygosity and lungworm burden in harbour seals (phoca vitulina) |
publishDate |
2008 |
url |
http://repub.eur.nl/pub/29120 https://doi.org/10.1038/hdy.2008.18 |
genre |
harbour seal Phoca vitulina |
genre_facet |
harbour seal Phoca vitulina |
op_source |
Heredity vol. 100 no. 6, pp. 587-593 |
op_relation |
http://repub.eur.nl/pub/29120 doi:10.1038/hdy.2008.18 urn:hdl:1765/29120 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/hdy.2008.18 |
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