An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species
Pestiviruses typically infect members of the order Artiodactyla, including ruminants and pigs, although putative rat and bat pestiviruses have also been described. In the present study, we identified and characterized an evolutionary divergent pestivirus in the toothed whale species, harbour porpois...
Published in: | Emerging Microbes & Infections |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://repub.eur.nl/pub/119800 https://doi.org/10.1080/22221751.2019.1664940 |
id |
ftunivrotterdam:oai:repub.eur.nl:119800 |
---|---|
record_format |
openpolar |
spelling |
ftunivrotterdam:oai:repub.eur.nl:119800 2024-06-02T08:07:47+00:00 An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species Jo, W.K. (Wendy K.) Elk, C.E. (Niels) van Bildt, M.W.G. (Marco) van de Run, P.R.W.A. (Peter) van Petry, M. (Monique) Jesse, S.T. (Sonja T.) Jung, K. (Klaus) Ludlow, M. (Martin) Kuiken, T. (Thijs) Osterhaus, A. (Albert) 2018-09-17 application/pdf https://repub.eur.nl/pub/119800 https://doi.org/10.1080/22221751.2019.1664940 en eng https://repub.eur.nl/pub/119800 doi:10.1080/22221751.2019.1664940 urn:hdl:1765/119800 Emerging Microbes and Infections vol. 8 no. 1, pp. 1383-1392 Pestivirus porpoise systemic marine mammal Npro info:eu-repo/semantics/article 2018 ftunivrotterdam https://doi.org/10.1080/22221751.2019.1664940 2024-05-06T17:22:08Z Pestiviruses typically infect members of the order Artiodactyla, including ruminants and pigs, although putative rat and bat pestiviruses have also been described. In the present study, we identified and characterized an evolutionary divergent pestivirus in the toothed whale species, harbour porpoise (Phocoena phocoena). We tentatively named the virus Phocoena pestivirus (PhoPeV). PhoPeV displays a typical pestivirus genome organization except for the unique absence of Npro, an N-terminal autoprotease that targets the innate host immune response. Evolutionary evidence indicates that PhoPeV emerged following an interspecies transmission event from an ancestral pestivirus that expressed Npro. We show that 9% (n = 10) of stranded porpoises from the Dutch North Sea coast (n = 112) were positive for PhoPeV and they displayed a systemic infection reminiscent of non-cytopathogenic persistent pestivirus infection. The identification of PhoPeV extends the host range of pestiviruses to cetaceans (dolphins, whales, porpoises), which are considered to have evolved from artiodactyls (even-toed ungulates). Elucidation of the pathophysiology of PhoPeV infection and Npro unique absence will add to our understanding of molecular mechanisms governing pestivirus pathogenesis. Article in Journal/Newspaper Harbour porpoise Phocoena phocoena toothed whale RePub - Publications from Erasmus University, Rotterdam Emerging Microbes & Infections 8 1 1383 1392 |
institution |
Open Polar |
collection |
RePub - Publications from Erasmus University, Rotterdam |
op_collection_id |
ftunivrotterdam |
language |
English |
topic |
Pestivirus porpoise systemic marine mammal Npro |
spellingShingle |
Pestivirus porpoise systemic marine mammal Npro Jo, W.K. (Wendy K.) Elk, C.E. (Niels) van Bildt, M.W.G. (Marco) van de Run, P.R.W.A. (Peter) van Petry, M. (Monique) Jesse, S.T. (Sonja T.) Jung, K. (Klaus) Ludlow, M. (Martin) Kuiken, T. (Thijs) Osterhaus, A. (Albert) An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
topic_facet |
Pestivirus porpoise systemic marine mammal Npro |
description |
Pestiviruses typically infect members of the order Artiodactyla, including ruminants and pigs, although putative rat and bat pestiviruses have also been described. In the present study, we identified and characterized an evolutionary divergent pestivirus in the toothed whale species, harbour porpoise (Phocoena phocoena). We tentatively named the virus Phocoena pestivirus (PhoPeV). PhoPeV displays a typical pestivirus genome organization except for the unique absence of Npro, an N-terminal autoprotease that targets the innate host immune response. Evolutionary evidence indicates that PhoPeV emerged following an interspecies transmission event from an ancestral pestivirus that expressed Npro. We show that 9% (n = 10) of stranded porpoises from the Dutch North Sea coast (n = 112) were positive for PhoPeV and they displayed a systemic infection reminiscent of non-cytopathogenic persistent pestivirus infection. The identification of PhoPeV extends the host range of pestiviruses to cetaceans (dolphins, whales, porpoises), which are considered to have evolved from artiodactyls (even-toed ungulates). Elucidation of the pathophysiology of PhoPeV infection and Npro unique absence will add to our understanding of molecular mechanisms governing pestivirus pathogenesis. |
format |
Article in Journal/Newspaper |
author |
Jo, W.K. (Wendy K.) Elk, C.E. (Niels) van Bildt, M.W.G. (Marco) van de Run, P.R.W.A. (Peter) van Petry, M. (Monique) Jesse, S.T. (Sonja T.) Jung, K. (Klaus) Ludlow, M. (Martin) Kuiken, T. (Thijs) Osterhaus, A. (Albert) |
author_facet |
Jo, W.K. (Wendy K.) Elk, C.E. (Niels) van Bildt, M.W.G. (Marco) van de Run, P.R.W.A. (Peter) van Petry, M. (Monique) Jesse, S.T. (Sonja T.) Jung, K. (Klaus) Ludlow, M. (Martin) Kuiken, T. (Thijs) Osterhaus, A. (Albert) |
author_sort |
Jo, W.K. (Wendy K.) |
title |
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
title_short |
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
title_full |
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
title_fullStr |
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
title_full_unstemmed |
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species |
title_sort |
evolutionary divergent pestivirus lacking the npro gene systemically infects a whale species |
publishDate |
2018 |
url |
https://repub.eur.nl/pub/119800 https://doi.org/10.1080/22221751.2019.1664940 |
genre |
Harbour porpoise Phocoena phocoena toothed whale |
genre_facet |
Harbour porpoise Phocoena phocoena toothed whale |
op_source |
Emerging Microbes and Infections vol. 8 no. 1, pp. 1383-1392 |
op_relation |
https://repub.eur.nl/pub/119800 doi:10.1080/22221751.2019.1664940 urn:hdl:1765/119800 |
op_doi |
https://doi.org/10.1080/22221751.2019.1664940 |
container_title |
Emerging Microbes & Infections |
container_volume |
8 |
container_issue |
1 |
container_start_page |
1383 |
op_container_end_page |
1392 |
_version_ |
1800752907600003072 |