Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas
Mitochondrial and Y-chromosome DNA were analyzed from 10,300-year-old human remains excavated from On Your Knees Cave on Prince of Wales Island, Alaska (Site 49-PET-408). This individual's mitochondrial DNA (mtDNA) represents the founder haplotype of an additional subhaplogroup of haplogroup D...
Published in: | American Journal of Physical Anthropology |
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Language: | English |
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2007
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Online Access: | http://hdl.handle.net/2108/34811 https://doi.org/10.1002/ajpa.20543 |
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ftunivromatorver:oai:art.torvergata.it:2108/34811 2024-02-27T08:45:00+00:00 Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas Kemp, BM Malhi, RS McDonough, J Bolnick, DA Eshleman, JA Rickards, O Martinez-Labarga, C Johnson, JR Lorenz, JG Dixon, EJ Fifield, TE Heaton, TH Worl, R Smith, DG Kemp, B Malhi, R Mcdonough, J Bolnick, D Eshleman, J Rickards, O Martinez-Labarga, C Johnson, J Lorenz, J Dixon, E Fifield, T Heaton, T Worl, R Smith, D 2007 http://hdl.handle.net/2108/34811 https://doi.org/10.1002/ajpa.20543 eng eng Wiley-Blackwell country:GB info:eu-repo/semantics/altIdentifier/pmid/17243155 info:eu-repo/semantics/altIdentifier/wos/WOS:000245160500014 volume:132 issue:4 firstpage:605 lastpage:621 numberofpages:17 journal:AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY http://hdl.handle.net/2108/34811 doi:10.1002/ajpa.20543 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33947500845 Ancient DNA Mitochondrial DNA Molecular clock Phylogenetic dispersion Y-chromosome Settore BIO/08 - ANTROPOLOGIA Settore BIO/18 - GENETICA info:eu-repo/semantics/article 2007 ftunivromatorver https://doi.org/10.1002/ajpa.20543 2024-01-31T00:03:01Z Mitochondrial and Y-chromosome DNA were analyzed from 10,300-year-old human remains excavated from On Your Knees Cave on Prince of Wales Island, Alaska (Site 49-PET-408). This individual's mitochondrial DNA (mtDNA) represents the founder haplotype of an additional subhaplogroup of haplogroup D that was brought to the Americas, demonstrating that widely held assumptions about the genetic composition of the earliest Americans are incorrect. The amount of diversity that has accumulated in the subhaplogroup over the past 10,300 years suggests that previous calibrations of the mtDNA clock may have underestimated the rate of molecular evolution. If substantiated, the dates of events based on these previous estimates are too old, which may explain the discordance between inferences based on genetic and archaeological evidence regarding the timing of the settlement of the Americas. In addition, this individual's Y-chromosome belongs to haplogroup Q-M3*, placing a minimum date of 10,300 years ago for the emergence of this haplogroup. ©2007 Wiley-Liss, Inc. Article in Journal/Newspaper Prince of Wales Island Alaska Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca Prince of Wales Island ENVELOPE(-99.001,-99.001,72.668,72.668) American Journal of Physical Anthropology 132 4 605 621 |
institution |
Open Polar |
collection |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
op_collection_id |
ftunivromatorver |
language |
English |
topic |
Ancient DNA Mitochondrial DNA Molecular clock Phylogenetic dispersion Y-chromosome Settore BIO/08 - ANTROPOLOGIA Settore BIO/18 - GENETICA |
spellingShingle |
Ancient DNA Mitochondrial DNA Molecular clock Phylogenetic dispersion Y-chromosome Settore BIO/08 - ANTROPOLOGIA Settore BIO/18 - GENETICA Kemp, BM Malhi, RS McDonough, J Bolnick, DA Eshleman, JA Rickards, O Martinez-Labarga, C Johnson, JR Lorenz, JG Dixon, EJ Fifield, TE Heaton, TH Worl, R Smith, DG Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
topic_facet |
Ancient DNA Mitochondrial DNA Molecular clock Phylogenetic dispersion Y-chromosome Settore BIO/08 - ANTROPOLOGIA Settore BIO/18 - GENETICA |
description |
Mitochondrial and Y-chromosome DNA were analyzed from 10,300-year-old human remains excavated from On Your Knees Cave on Prince of Wales Island, Alaska (Site 49-PET-408). This individual's mitochondrial DNA (mtDNA) represents the founder haplotype of an additional subhaplogroup of haplogroup D that was brought to the Americas, demonstrating that widely held assumptions about the genetic composition of the earliest Americans are incorrect. The amount of diversity that has accumulated in the subhaplogroup over the past 10,300 years suggests that previous calibrations of the mtDNA clock may have underestimated the rate of molecular evolution. If substantiated, the dates of events based on these previous estimates are too old, which may explain the discordance between inferences based on genetic and archaeological evidence regarding the timing of the settlement of the Americas. In addition, this individual's Y-chromosome belongs to haplogroup Q-M3*, placing a minimum date of 10,300 years ago for the emergence of this haplogroup. ©2007 Wiley-Liss, Inc. |
author2 |
Kemp, B Malhi, R Mcdonough, J Bolnick, D Eshleman, J Rickards, O Martinez-Labarga, C Johnson, J Lorenz, J Dixon, E Fifield, T Heaton, T Worl, R Smith, D |
format |
Article in Journal/Newspaper |
author |
Kemp, BM Malhi, RS McDonough, J Bolnick, DA Eshleman, JA Rickards, O Martinez-Labarga, C Johnson, JR Lorenz, JG Dixon, EJ Fifield, TE Heaton, TH Worl, R Smith, DG |
author_facet |
Kemp, BM Malhi, RS McDonough, J Bolnick, DA Eshleman, JA Rickards, O Martinez-Labarga, C Johnson, JR Lorenz, JG Dixon, EJ Fifield, TE Heaton, TH Worl, R Smith, DG |
author_sort |
Kemp, BM |
title |
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
title_short |
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
title_full |
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
title_fullStr |
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
title_full_unstemmed |
Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas |
title_sort |
genetic analysis of early holocene skeletal remains from alaska and its implications for the settlement of the americas |
publisher |
Wiley-Blackwell |
publishDate |
2007 |
url |
http://hdl.handle.net/2108/34811 https://doi.org/10.1002/ajpa.20543 |
long_lat |
ENVELOPE(-99.001,-99.001,72.668,72.668) |
geographic |
Prince of Wales Island |
geographic_facet |
Prince of Wales Island |
genre |
Prince of Wales Island Alaska |
genre_facet |
Prince of Wales Island Alaska |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/17243155 info:eu-repo/semantics/altIdentifier/wos/WOS:000245160500014 volume:132 issue:4 firstpage:605 lastpage:621 numberofpages:17 journal:AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY http://hdl.handle.net/2108/34811 doi:10.1002/ajpa.20543 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33947500845 |
op_doi |
https://doi.org/10.1002/ajpa.20543 |
container_title |
American Journal of Physical Anthropology |
container_volume |
132 |
container_issue |
4 |
container_start_page |
605 |
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621 |
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