Compounds from natural sources for new diagnostics and drugs against biofilm infections
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth a...
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ftunivromairis:oai:iris.uniroma1.it:11573/911335 2024-02-11T09:58:27+01:00 Compounds from natural sources for new diagnostics and drugs against biofilm infections SELAN, Laura ARTINI, Marco PAPA, Rosanna Edited by Dharumadurai Dhanasekaran co-editor: Nooruddin Thajuddin Selan, Laura Artini, Marco Papa, Rosanna 2016 ELETTRONICO http://hdl.handle.net/11573/911335 https://doi.org/10.5772/62908 http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/compounds-from-natural-sources-for-new-diagnostics-and-drugs-against-biofilm-infections eng eng Intechopen info:eu-repo/semantics/altIdentifier/isbn/978-953-51-2435-1 ispartofbook:Microbial biofilms. Importance and applications firstpage:487 lastpage:509 numberofpages:23 http://hdl.handle.net/11573/911335 doi:10.5772/62908 http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/compounds-from-natural-sources-for-new-diagnostics-and-drugs-against-biofilm-infections info:eu-repo/semantics/openAccess human disease infection therapy diagnosis info:eu-repo/semantics/bookPart 2016 ftunivromairis https://doi.org/10.5772/62908 2024-01-24T17:52:02Z Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. Book Part Antarc* Antarctic Sapienza Università di Roma: CINECA IRIS Antarctic |
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Sapienza Università di Roma: CINECA IRIS |
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ftunivromairis |
language |
English |
topic |
human disease infection therapy diagnosis |
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human disease infection therapy diagnosis SELAN, Laura ARTINI, Marco PAPA, Rosanna Compounds from natural sources for new diagnostics and drugs against biofilm infections |
topic_facet |
human disease infection therapy diagnosis |
description |
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. |
author2 |
Edited by Dharumadurai Dhanasekaran co-editor: Nooruddin Thajuddin Selan, Laura Artini, Marco Papa, Rosanna |
format |
Book Part |
author |
SELAN, Laura ARTINI, Marco PAPA, Rosanna |
author_facet |
SELAN, Laura ARTINI, Marco PAPA, Rosanna |
author_sort |
SELAN, Laura |
title |
Compounds from natural sources for new diagnostics and drugs against biofilm infections |
title_short |
Compounds from natural sources for new diagnostics and drugs against biofilm infections |
title_full |
Compounds from natural sources for new diagnostics and drugs against biofilm infections |
title_fullStr |
Compounds from natural sources for new diagnostics and drugs against biofilm infections |
title_full_unstemmed |
Compounds from natural sources for new diagnostics and drugs against biofilm infections |
title_sort |
compounds from natural sources for new diagnostics and drugs against biofilm infections |
publisher |
Intechopen |
publishDate |
2016 |
url |
http://hdl.handle.net/11573/911335 https://doi.org/10.5772/62908 http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/compounds-from-natural-sources-for-new-diagnostics-and-drugs-against-biofilm-infections |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/isbn/978-953-51-2435-1 ispartofbook:Microbial biofilms. Importance and applications firstpage:487 lastpage:509 numberofpages:23 http://hdl.handle.net/11573/911335 doi:10.5772/62908 http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/compounds-from-natural-sources-for-new-diagnostics-and-drugs-against-biofilm-infections |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.5772/62908 |
_version_ |
1790594101981216768 |