Antibacterial activity of selected metabolites from Chilean lichen species against methycillin-resistan staphylococci

• Published in: Natural Product Research
• Main Authors: Giuseppe Celenza, Bernardetta Segatore, Domenico Setacci, Mariagrazia Perilli, Fabrizia Brisdelli, Pierangelo Bellio, Marisa Piovano, Juan A. Garbarino, Gianfranco Amicosante, NICOLETTI, Marcello
• Other Authors: Giuseppe, Celenza, Bernardetta, Segatore, Domenico, Setacci, Mariagrazia, Perilli, Fabrizia, Brisdelli, Pierangelo, Bellio, Marisa, Piovano, Juan A., Garbarino, Gianfranco, Amicosante, Nicoletti, Marcello
• Format: Article in Journal/Newspaper
• Language: English
• Published: TAYLOR & FRANCIS LTD 2013
• Subjects: antimicrobial resistance; methicillin-resistant staphylococci; lichen secondary metabolite; antibacterial activity; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11573/626036; https://doi.org/10.1080/14786419.2012.730043

The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.