Histidine and not tyrosine is required for the peroxide-induced formation of haem to protein cross-linked myoglobin

• Published in: IUBMB Life
• Main Authors: Brandon J. Reeder, Maria Giulia Bigotti, Nicholas J. Watmough, Michael T. Wilson, CUTRUZZOLA', Francesca
• Other Authors: Brandon J., Reeder, Cutruzzola', Francesca, Maria Giulia, Bigotti, Nicholas J., Watmough, Michael T., Wilson
• Format: Article in Journal/Newspaper
• Language: English
• Published: TAYLOR & FRANCIS INC 2007
• Subjects: aplysia; ferryl; histidine; myoglobin; peroxide; tyrosine; Ortiz; Sperm whale
• Online Access: http://hdl.handle.net/11573/47541; https://doi.org/10.1080/15216540601178083; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000248721400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a; http://www.scopus.com/inward/record.url?eid=2-s2.0-34547948951&partnerID=65&md5=0b3b97eabe7355adee37ec62e637061b

Peroxide- induced oxidative modi. cations of haem proteins such as myoglobin and haemoglobin can lead to the formation of a covalent bond between the haem and globin. These haem to protein cross- linked forms of myoglobin and haemoglobin are cytotoxic and have been identified in pathological conditi...