Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations
A major challenge in evolutionary biology is to identify the genes underlying adaptation. The oxygen-transporting haemoglobins directly link external conditions with metabolic needs and therefore represent a unique system for studying environmental effects on molecular evolution. We have discovered...
Published in: | Proceedings of the Royal Society B: Biological Sciences |
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Format: | Article in Journal/Newspaper |
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ROYAL SOC
2009
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Online Access: | http://hdl.handle.net/11573/24721 https://doi.org/10.1098/rspb.2008.1529 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000262867100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-84863426053&partnerID=65&md5=199b319c87e05586f60139bcdf2cce05 |
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ftunivromairis:oai:iris.uniroma1.it:11573/24721 2024-04-14T08:08:12+00:00 Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations Ø. Andersen O. F. Wetten M. C. De Rosa C. Andre C. Carelli Alinovi M. Colafranceschi COLOSIMO, Alfredo Ø., Andersen O. F., Wetten M. C., De Rosa C., Andre C., Carelli Alinovi M., Colafranceschi Colosimo, Alfredo 2009 http://hdl.handle.net/11573/24721 https://doi.org/10.1098/rspb.2008.1529 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000262867100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-84863426053&partnerID=65&md5=199b319c87e05586f60139bcdf2cce05 eng eng ROYAL SOC info:eu-repo/semantics/altIdentifier/pmid/19033139 info:eu-repo/semantics/altIdentifier/wos/WOS:000262867100006 volume:276 issue:1658 firstpage:833 lastpage:841 numberofpages:9 journal:PROCEEDINGS - ROYAL SOCIETY. BIOLOGICAL SCIENCES http://hdl.handle.net/11573/24721 doi:10.1098/rspb.2008.1529 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-63849144663 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000262867100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-84863426053&partnerID=65&md5=199b319c87e05586f60139bcdf2cce05 adaptation convergent evolution gadus morhua haemoglobin oxygen affinity polymorphism info:eu-repo/semantics/article 2009 ftunivromairis https://doi.org/10.1098/rspb.2008.1529 2024-03-21T18:37:23Z A major challenge in evolutionary biology is to identify the genes underlying adaptation. The oxygen-transporting haemoglobins directly link external conditions with metabolic needs and therefore represent a unique system for studying environmental effects on molecular evolution. We have discovered two haemoglobin polymorphisms in Atlantic cod populations inhabiting varying temperature and oxygen regimes in the North Atlantic. Three-dimensional modelling of the tetrameric haemoglobin structure demonstrated that the two amino acid replacements Met55 beta(1)Val and Lys62 beta(1)Ala are located at crucial positions of the alpha(1)beta(1) subunit interface and haem pocket, respectively. The replacements are proposed to affect the oxygen-binding properties by modifying the haemoglobin quaternary structure and electrostatic feature. Intriguingly, the same molecular mechanism for facilitating oxygen binding is found in avian species adapted to high altitudes, illustrating convergent evolution in water- and air-breathing vertebrates to reduction in environmental oxygen availability. Cod populations inhabiting the cold Arctic waters and the low-oxygen Baltic Sea seem well adapted to these conditions by possessing the high oxygen affinity Val55-Ala62 haplotype, while the temperature-insensitive Met55-Lys62 haplotype predominates in the southern populations. The distinct distributions of the functionally different haemoglobin variants indicate that the present biogeography of this ecologically and economically important species might be seriously affected by global warming. Article in Journal/Newspaper Arctic atlantic cod Gadus morhua Global warming North Atlantic Sapienza Università di Roma: CINECA IRIS Arctic Proceedings of the Royal Society B: Biological Sciences 276 1658 833 841 |
institution |
Open Polar |
collection |
Sapienza Università di Roma: CINECA IRIS |
op_collection_id |
ftunivromairis |
language |
English |
topic |
adaptation convergent evolution gadus morhua haemoglobin oxygen affinity polymorphism |
spellingShingle |
adaptation convergent evolution gadus morhua haemoglobin oxygen affinity polymorphism Ø. Andersen O. F. Wetten M. C. De Rosa C. Andre C. Carelli Alinovi M. Colafranceschi COLOSIMO, Alfredo Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
topic_facet |
adaptation convergent evolution gadus morhua haemoglobin oxygen affinity polymorphism |
description |
A major challenge in evolutionary biology is to identify the genes underlying adaptation. The oxygen-transporting haemoglobins directly link external conditions with metabolic needs and therefore represent a unique system for studying environmental effects on molecular evolution. We have discovered two haemoglobin polymorphisms in Atlantic cod populations inhabiting varying temperature and oxygen regimes in the North Atlantic. Three-dimensional modelling of the tetrameric haemoglobin structure demonstrated that the two amino acid replacements Met55 beta(1)Val and Lys62 beta(1)Ala are located at crucial positions of the alpha(1)beta(1) subunit interface and haem pocket, respectively. The replacements are proposed to affect the oxygen-binding properties by modifying the haemoglobin quaternary structure and electrostatic feature. Intriguingly, the same molecular mechanism for facilitating oxygen binding is found in avian species adapted to high altitudes, illustrating convergent evolution in water- and air-breathing vertebrates to reduction in environmental oxygen availability. Cod populations inhabiting the cold Arctic waters and the low-oxygen Baltic Sea seem well adapted to these conditions by possessing the high oxygen affinity Val55-Ala62 haplotype, while the temperature-insensitive Met55-Lys62 haplotype predominates in the southern populations. The distinct distributions of the functionally different haemoglobin variants indicate that the present biogeography of this ecologically and economically important species might be seriously affected by global warming. |
author2 |
Ø., Andersen O. F., Wetten M. C., De Rosa C., Andre C., Carelli Alinovi M., Colafranceschi Colosimo, Alfredo |
format |
Article in Journal/Newspaper |
author |
Ø. Andersen O. F. Wetten M. C. De Rosa C. Andre C. Carelli Alinovi M. Colafranceschi COLOSIMO, Alfredo |
author_facet |
Ø. Andersen O. F. Wetten M. C. De Rosa C. Andre C. Carelli Alinovi M. Colafranceschi COLOSIMO, Alfredo |
author_sort |
Ø. Andersen |
title |
Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
title_short |
Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
title_full |
Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
title_fullStr |
Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
title_full_unstemmed |
Haemoglobin polymorphisms affect the oxygen-binding properties in Atlantic cod populations |
title_sort |
haemoglobin polymorphisms affect the oxygen-binding properties in atlantic cod populations |
publisher |
ROYAL SOC |
publishDate |
2009 |
url |
http://hdl.handle.net/11573/24721 https://doi.org/10.1098/rspb.2008.1529 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000262867100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-84863426053&partnerID=65&md5=199b319c87e05586f60139bcdf2cce05 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic atlantic cod Gadus morhua Global warming North Atlantic |
genre_facet |
Arctic atlantic cod Gadus morhua Global warming North Atlantic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/19033139 info:eu-repo/semantics/altIdentifier/wos/WOS:000262867100006 volume:276 issue:1658 firstpage:833 lastpage:841 numberofpages:9 journal:PROCEEDINGS - ROYAL SOCIETY. BIOLOGICAL SCIENCES http://hdl.handle.net/11573/24721 doi:10.1098/rspb.2008.1529 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-63849144663 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000262867100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-84863426053&partnerID=65&md5=199b319c87e05586f60139bcdf2cce05 |
op_doi |
https://doi.org/10.1098/rspb.2008.1529 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
276 |
container_issue |
1658 |
container_start_page |
833 |
op_container_end_page |
841 |
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