Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens
The ESKAPE pathogens, including bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system....
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2023
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Online Access: | https://hdl.handle.net/11573/1691747 https://doi.org/10.3390/antibiotics12101556 |
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ftunivromairis:oai:iris.uniroma1.it:11573/1691747 2024-04-14T08:03:28+00:00 Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens Artini M. Papa R. Vrenna G. Trecca M. Paris I. D'Angelo C. Tutino M. L. Parrilli E. Selan L. Artini, M. Papa, R. Vrenna, G. Trecca, M. Paris, I. D'Angelo, C. Tutino, M. L. Parrilli, E. Selan, L. 2023 https://hdl.handle.net/11573/1691747 https://doi.org/10.3390/antibiotics12101556 eng eng info:eu-repo/semantics/altIdentifier/pmid/37887257 info:eu-repo/semantics/altIdentifier/wos/WOS:001099602800001 volume:12 issue:10 firstpage:1 lastpage:24 numberofpages:24 journal:ANTIBIOTICS https://hdl.handle.net/11573/1691747 doi:10.3390/antibiotics12101556 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85175267961 info:eu-repo/semantics/openAccess enterococcus faecium staphylococcus aureu klebsiella pneumoniae acinetobacter baumannii pseudomonas aeruginosa enterobacter sp biofilm info:eu-repo/semantics/article 2023 ftunivromairis https://doi.org/10.3390/antibiotics12101556 2024-03-21T18:35:03Z The ESKAPE pathogens, including bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens. Article in Journal/Newspaper Antarc* Antarctic Sapienza Università di Roma: CINECA IRIS Antarctic Antibiotics 12 10 1556 |
institution |
Open Polar |
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Sapienza Università di Roma: CINECA IRIS |
op_collection_id |
ftunivromairis |
language |
English |
topic |
enterococcus faecium staphylococcus aureu klebsiella pneumoniae acinetobacter baumannii pseudomonas aeruginosa enterobacter sp biofilm |
spellingShingle |
enterococcus faecium staphylococcus aureu klebsiella pneumoniae acinetobacter baumannii pseudomonas aeruginosa enterobacter sp biofilm Artini M. Papa R. Vrenna G. Trecca M. Paris I. D'Angelo C. Tutino M. L. Parrilli E. Selan L. Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
topic_facet |
enterococcus faecium staphylococcus aureu klebsiella pneumoniae acinetobacter baumannii pseudomonas aeruginosa enterobacter sp biofilm |
description |
The ESKAPE pathogens, including bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens. |
author2 |
Artini, M. Papa, R. Vrenna, G. Trecca, M. Paris, I. D'Angelo, C. Tutino, M. L. Parrilli, E. Selan, L. |
format |
Article in Journal/Newspaper |
author |
Artini M. Papa R. Vrenna G. Trecca M. Paris I. D'Angelo C. Tutino M. L. Parrilli E. Selan L. |
author_facet |
Artini M. Papa R. Vrenna G. Trecca M. Paris I. D'Angelo C. Tutino M. L. Parrilli E. Selan L. |
author_sort |
Artini M. |
title |
Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
title_short |
Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
title_full |
Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
title_fullStr |
Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
title_full_unstemmed |
Antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
title_sort |
antarctic marine bacteria as a source of anti-biofilm molecules to combat askape pathogens |
publishDate |
2023 |
url |
https://hdl.handle.net/11573/1691747 https://doi.org/10.3390/antibiotics12101556 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/37887257 info:eu-repo/semantics/altIdentifier/wos/WOS:001099602800001 volume:12 issue:10 firstpage:1 lastpage:24 numberofpages:24 journal:ANTIBIOTICS https://hdl.handle.net/11573/1691747 doi:10.3390/antibiotics12101556 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85175267961 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/antibiotics12101556 |
container_title |
Antibiotics |
container_volume |
12 |
container_issue |
10 |
container_start_page |
1556 |
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1796299727052996608 |