Integrated Assessment of Predicted MHC binding and Cross-conservation with Self Reveals Patterns of Viral Camouflage

• Published in: BMC Bioinformatics
• Main Authors: He, Lu, DeGroot, Anne S., Gutierrez, Andres H., Martin, William D., Moise, Lenny, Bailey-Kellogg, Chris
• Format: Text
• Language: unknown
• Published: DigitalCommons@URI 2014
• Subjects: Avian flu
• Online Access: https://digitalcommons.uri.edu/immunology_facpubs/11; https://doi.org/10.1186/1471-2105-15-S4-S1; https://digitalcommons.uri.edu/context/immunology_facpubs/article/1008/viewcontent/DeGroot_Integrated_2014.pdf

Background Immune recognition of foreign proteins by T cells hinges on the formation of a ternary complex sandwiching a constituent peptide of the protein between a major histocompatibility complex (MHC) molecule and a T cell receptor (TCR). Viruses have evolved means of "camouflaging" the...