Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade
International audience BACKGROUND:Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb expos...
Published in: | Environmental Research |
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Main Authors: | , , , , , , , , , |
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Language: | English |
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2019
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Online Access: | https://univ-rennes.hal.science/hal-02280778 https://univ-rennes.hal.science/hal-02280778/document https://univ-rennes.hal.science/hal-02280778/file/Desrochers-Couture%20et%20al-2019-Association%20between%20early%20lead%20exposure.pdf https://doi.org/10.1016/j.envres.2019.108679 |
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Université de Rennes 1: Publications scientifiques (HAL) |
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ftunivrennes1hal |
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English |
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Lead Binge drinking Children and adolescents Externalizing behaviors Cannabis use [SDV]Life Sciences [q-bio] |
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Lead Binge drinking Children and adolescents Externalizing behaviors Cannabis use [SDV]Life Sciences [q-bio] Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L Jacobson, Sandra W Muckle, Gina Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
topic_facet |
Lead Binge drinking Children and adolescents Externalizing behaviors Cannabis use [SDV]Life Sciences [q-bio] |
description |
International audience BACKGROUND:Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb exposure later in life is however scarce. Pb exposure may initiate a developmental cascade that increases the risk of long-term behavior problems.OBJECTIVES:Testing for direct associations between childhood Pb concentrations and adolescent externalizing symptoms and substance use, as well as indirect associations through childhood behavior assessments.METHODS:The study sample is a longitudinal cohort of Inuit children (n = 212) followed since birth. Blood Pb concentrations were measured during childhood (median age = 11.4 years) and adolescence (median age = 18.5 years). Externalizing/inattentive behavior were teacher-assessed through the Teacher Report Form and the Disruptive Behavior Disorders Rating Scale for children. At the adolescence follow-up, behavior problems were self-reported by filling Achenbach's Youth Self-Report, the Barkley Adult ADHD-IV Rating Scale, and the Diagnostics Interview Schedule for Children. Adolescent substance use was also self-assessed through the DEP-ADO. Direct and indirect associations of child Pb concentrations with adolescent outcomes were tested through mediation models.RESULTS:Child blood Pb concentrations were not directly associated with any adolescent outcomes. On the contrary, childhood Pb exposure was indirectly associated, through childhood externalizing behavior assessments, with adolescent externalizing behaviors, binge drinking, and cannabis use. These indirect associations held after controlling for adolescents' concurrent Pb blood concentrations.DISCUSSION:Our results highlight the indirect but lasting effects of child Pb exposure on adolescent behavior problems, and the importance of childhood externalizing behavior in this relationship. Adverse early-life environment ... |
author2 |
CHU de Québec–Université Laval Université Laval Québec (ULaval) Université de Montréal (UdeM) Institut de recherche en santé, environnement et travail (Irset) Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Wayne State University Detroit NRF 130242, Canadian Institutes of Health Research National Institutes of Health R01-ES007902, National Institute of Environmental Health Sciences Northern Contaminants Program from Government Canada |
format |
Article in Journal/Newspaper |
author |
Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L Jacobson, Sandra W Muckle, Gina |
author_facet |
Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L Jacobson, Sandra W Muckle, Gina |
author_sort |
Desrochers-Couture, Mireille |
title |
Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
title_short |
Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
title_full |
Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
title_fullStr |
Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
title_full_unstemmed |
Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade |
title_sort |
association between early lead exposure and externalizing behaviors in adolescence: a developmental cascade |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://univ-rennes.hal.science/hal-02280778 https://univ-rennes.hal.science/hal-02280778/document https://univ-rennes.hal.science/hal-02280778/file/Desrochers-Couture%20et%20al-2019-Association%20between%20early%20lead%20exposure.pdf https://doi.org/10.1016/j.envres.2019.108679 |
genre |
inuit |
genre_facet |
inuit |
op_source |
ISSN: 0013-9351 EISSN: 1096-0953 Environmental Research https://univ-rennes.hal.science/hal-02280778 Environmental Research, 2019, 178, pp.108679. ⟨10.1016/j.envres.2019.108679⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2019.108679 info:eu-repo/semantics/altIdentifier/pmid/31454729 hal-02280778 https://univ-rennes.hal.science/hal-02280778 https://univ-rennes.hal.science/hal-02280778/document https://univ-rennes.hal.science/hal-02280778/file/Desrochers-Couture%20et%20al-2019-Association%20between%20early%20lead%20exposure.pdf doi:10.1016/j.envres.2019.108679 PUBMED: 31454729 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1016/j.envres.2019.108679 |
container_title |
Environmental Research |
container_volume |
178 |
container_start_page |
108679 |
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1799482847016255488 |
spelling |
ftunivrennes1hal:oai:HAL:hal-02280778v1 2024-05-19T07:43:08+00:00 Association between early lead exposure and externalizing behaviors in adolescence: A developmental cascade Desrochers-Couture, Mireille Courtemanche, Yohann Forget-Dubois, Nadine Bélanger, Richard E Boucher, Olivier Ayotte, Pierre Cordier, Sylvaine Jacobson, Joseph L Jacobson, Sandra W Muckle, Gina CHU de Québec–Université Laval Université Laval Québec (ULaval) Université de Montréal (UdeM) Institut de recherche en santé, environnement et travail (Irset) Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Wayne State University Detroit NRF 130242, Canadian Institutes of Health Research National Institutes of Health R01-ES007902, National Institute of Environmental Health Sciences Northern Contaminants Program from Government Canada 2019-11 https://univ-rennes.hal.science/hal-02280778 https://univ-rennes.hal.science/hal-02280778/document https://univ-rennes.hal.science/hal-02280778/file/Desrochers-Couture%20et%20al-2019-Association%20between%20early%20lead%20exposure.pdf https://doi.org/10.1016/j.envres.2019.108679 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2019.108679 info:eu-repo/semantics/altIdentifier/pmid/31454729 hal-02280778 https://univ-rennes.hal.science/hal-02280778 https://univ-rennes.hal.science/hal-02280778/document https://univ-rennes.hal.science/hal-02280778/file/Desrochers-Couture%20et%20al-2019-Association%20between%20early%20lead%20exposure.pdf doi:10.1016/j.envres.2019.108679 PUBMED: 31454729 info:eu-repo/semantics/OpenAccess ISSN: 0013-9351 EISSN: 1096-0953 Environmental Research https://univ-rennes.hal.science/hal-02280778 Environmental Research, 2019, 178, pp.108679. ⟨10.1016/j.envres.2019.108679⟩ Lead Binge drinking Children and adolescents Externalizing behaviors Cannabis use [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2019 ftunivrennes1hal https://doi.org/10.1016/j.envres.2019.108679 2024-04-25T00:09:52Z International audience BACKGROUND:Lead (Pb) exposure is associated with adverse neurological development. Most notably, it has been observed through externalizing behavior symptoms, as observed among Inuit children from northern Québec. Evidence for a persistent neurological impact of early Pb exposure later in life is however scarce. Pb exposure may initiate a developmental cascade that increases the risk of long-term behavior problems.OBJECTIVES:Testing for direct associations between childhood Pb concentrations and adolescent externalizing symptoms and substance use, as well as indirect associations through childhood behavior assessments.METHODS:The study sample is a longitudinal cohort of Inuit children (n = 212) followed since birth. Blood Pb concentrations were measured during childhood (median age = 11.4 years) and adolescence (median age = 18.5 years). Externalizing/inattentive behavior were teacher-assessed through the Teacher Report Form and the Disruptive Behavior Disorders Rating Scale for children. At the adolescence follow-up, behavior problems were self-reported by filling Achenbach's Youth Self-Report, the Barkley Adult ADHD-IV Rating Scale, and the Diagnostics Interview Schedule for Children. Adolescent substance use was also self-assessed through the DEP-ADO. Direct and indirect associations of child Pb concentrations with adolescent outcomes were tested through mediation models.RESULTS:Child blood Pb concentrations were not directly associated with any adolescent outcomes. On the contrary, childhood Pb exposure was indirectly associated, through childhood externalizing behavior assessments, with adolescent externalizing behaviors, binge drinking, and cannabis use. These indirect associations held after controlling for adolescents' concurrent Pb blood concentrations.DISCUSSION:Our results highlight the indirect but lasting effects of child Pb exposure on adolescent behavior problems, and the importance of childhood externalizing behavior in this relationship. Adverse early-life environment ... Article in Journal/Newspaper inuit Université de Rennes 1: Publications scientifiques (HAL) Environmental Research 178 108679 |