Adolescent inhalant use and psychosis risk - a prospective longitudinal study
Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders.We used a prospective sample (N = 6542) from the Northern Finland Birth Cohort 1986. Self-report questi...
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:b1043b8 2023-05-15T17:42:46+02:00 Adolescent inhalant use and psychosis risk - a prospective longitudinal study Mustonen, Antti Niemelä, Solja McGrath, John J. Murray, Graham K. Nordström, Tanja Mäki, Pirjo Miettunen, Jouko Scott, James G. 2018-06-27 https://espace.library.uq.edu.au/view/UQ:b1043b8 eng eng Elsevier BV doi:10.1016/j.schres.2018.05.013 issn:1573-2509 issn:0920-9964 orcid:0000-0002-4792-6068 orcid:0000-0002-0744-0688 QLG1-CT-2000-01643 E51560 731 20056 30167 268336 Not set APP1056929 1105807 Birth cohort Psychotic disorders Schizophrenia Substance abuse 2738 Psychiatry and Mental health 2803 Biological Psychiatry Journal Article 2018 ftunivqespace https://doi.org/10.1016/j.schres.2018.05.013 2020-12-08T04:05:23Z Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders.We used a prospective sample (N = 6542) from the Northern Finland Birth Cohort 1986. Self-report questionnaires on substance use and psychotic experiences were completed when the cohort members were 15-16 years old. Inhalant use was categorized into four groups (never, once, 2-4 times, 5 times or more). Subsequent psychosis diagnoses (ICD-10) until age 30 years were obtained from national registers. Cox regression analysis was used to examine the association between adolescent inhalant use and risk of psychosis.During the observation period 124 individuals were diagnosed with incident psychosis. Overall, there were 225 (3.4%) subjects with any inhalant use, 18 (8.0%) of whom were diagnosed with psychosis during the follow up. Of non-inhalant users (n = 6317) 106 (1.7%) were diagnosed with psychosis. Compared to non-users, those using inhalants had increased risk of incident psychosis with most frequent inhalant use associated with the greatest risk (unadjusted HR = 9.46; 3.86-23.20). After adjusting for baseline psychotic experiences, other substance use, comorbid mental disorder and parental substance abuse, the increased risk of psychosis persisted (HR = 3.06; 1.05-8.95). Furthermore, a dose-response effect between inhalant use and risk of psychosis was identified (OR = 2.34; 1.83-2.99).Inhalant use in adolescence was independently associated with incident psychosis. The adverse health outcomes associated with adolescent inhalant use provide compelling reasons for implementation of policies to reduce the use of volatile substances in adolescents. Article in Journal/Newspaper Northern Finland The University of Queensland: UQ eSpace Schizophrenia Research 201 360 366 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Birth cohort Psychotic disorders Schizophrenia Substance abuse 2738 Psychiatry and Mental health 2803 Biological Psychiatry |
spellingShingle |
Birth cohort Psychotic disorders Schizophrenia Substance abuse 2738 Psychiatry and Mental health 2803 Biological Psychiatry Mustonen, Antti Niemelä, Solja McGrath, John J. Murray, Graham K. Nordström, Tanja Mäki, Pirjo Miettunen, Jouko Scott, James G. Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
topic_facet |
Birth cohort Psychotic disorders Schizophrenia Substance abuse 2738 Psychiatry and Mental health 2803 Biological Psychiatry |
description |
Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders.We used a prospective sample (N = 6542) from the Northern Finland Birth Cohort 1986. Self-report questionnaires on substance use and psychotic experiences were completed when the cohort members were 15-16 years old. Inhalant use was categorized into four groups (never, once, 2-4 times, 5 times or more). Subsequent psychosis diagnoses (ICD-10) until age 30 years were obtained from national registers. Cox regression analysis was used to examine the association between adolescent inhalant use and risk of psychosis.During the observation period 124 individuals were diagnosed with incident psychosis. Overall, there were 225 (3.4%) subjects with any inhalant use, 18 (8.0%) of whom were diagnosed with psychosis during the follow up. Of non-inhalant users (n = 6317) 106 (1.7%) were diagnosed with psychosis. Compared to non-users, those using inhalants had increased risk of incident psychosis with most frequent inhalant use associated with the greatest risk (unadjusted HR = 9.46; 3.86-23.20). After adjusting for baseline psychotic experiences, other substance use, comorbid mental disorder and parental substance abuse, the increased risk of psychosis persisted (HR = 3.06; 1.05-8.95). Furthermore, a dose-response effect between inhalant use and risk of psychosis was identified (OR = 2.34; 1.83-2.99).Inhalant use in adolescence was independently associated with incident psychosis. The adverse health outcomes associated with adolescent inhalant use provide compelling reasons for implementation of policies to reduce the use of volatile substances in adolescents. |
format |
Article in Journal/Newspaper |
author |
Mustonen, Antti Niemelä, Solja McGrath, John J. Murray, Graham K. Nordström, Tanja Mäki, Pirjo Miettunen, Jouko Scott, James G. |
author_facet |
Mustonen, Antti Niemelä, Solja McGrath, John J. Murray, Graham K. Nordström, Tanja Mäki, Pirjo Miettunen, Jouko Scott, James G. |
author_sort |
Mustonen, Antti |
title |
Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
title_short |
Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
title_full |
Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
title_fullStr |
Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
title_full_unstemmed |
Adolescent inhalant use and psychosis risk - a prospective longitudinal study |
title_sort |
adolescent inhalant use and psychosis risk - a prospective longitudinal study |
publisher |
Elsevier BV |
publishDate |
2018 |
url |
https://espace.library.uq.edu.au/view/UQ:b1043b8 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
doi:10.1016/j.schres.2018.05.013 issn:1573-2509 issn:0920-9964 orcid:0000-0002-4792-6068 orcid:0000-0002-0744-0688 QLG1-CT-2000-01643 E51560 731 20056 30167 268336 Not set APP1056929 1105807 |
op_doi |
https://doi.org/10.1016/j.schres.2018.05.013 |
container_title |
Schizophrenia Research |
container_volume |
201 |
container_start_page |
360 |
op_container_end_page |
366 |
_version_ |
1766144682850516992 |