Repositioning of the global epicentre of non-optimal cholesterol
High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct eff...
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:8d658d3 2023-05-15T16:30:13+02:00 Repositioning of the global epicentre of non-optimal cholesterol Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula 2020-06-04 https://espace.library.uq.edu.au/view/UQ:8d658d3 eng eng Nature Publishing Group doi:10.1038/s41586-020-2338-1 issn:1476-4687 issn:0028-0836 01506/Z/13/Z RE/18/4/34215 203616/Z/16/Z Multidisciplinary 1000 General Journal Article 2020 ftunivqespace https://doi.org/10.1038/s41586-020-2338-1 2020-12-08T08:49:44Z High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world. Article in Journal/Newspaper Greenland Iceland The University of Queensland: UQ eSpace Greenland Norway Pacific Nature 582 7810 73 77 |
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The University of Queensland: UQ eSpace |
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ftunivqespace |
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English |
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Multidisciplinary 1000 General |
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Multidisciplinary 1000 General Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Repositioning of the global epicentre of non-optimal cholesterol |
topic_facet |
Multidisciplinary 1000 General |
description |
High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world. |
format |
Article in Journal/Newspaper |
author |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula |
author_facet |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula |
author_sort |
Taddei, Cristina |
title |
Repositioning of the global epicentre of non-optimal cholesterol |
title_short |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full |
Repositioning of the global epicentre of non-optimal cholesterol |
title_fullStr |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full_unstemmed |
Repositioning of the global epicentre of non-optimal cholesterol |
title_sort |
repositioning of the global epicentre of non-optimal cholesterol |
publisher |
Nature Publishing Group |
publishDate |
2020 |
url |
https://espace.library.uq.edu.au/view/UQ:8d658d3 |
geographic |
Greenland Norway Pacific |
geographic_facet |
Greenland Norway Pacific |
genre |
Greenland Iceland |
genre_facet |
Greenland Iceland |
op_relation |
doi:10.1038/s41586-020-2338-1 issn:1476-4687 issn:0028-0836 01506/Z/13/Z RE/18/4/34215 203616/Z/16/Z |
op_doi |
https://doi.org/10.1038/s41586-020-2338-1 |
container_title |
Nature |
container_volume |
582 |
container_issue |
7810 |
container_start_page |
73 |
op_container_end_page |
77 |
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1766019941357584384 |