Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study
Objective: Based on clues from epidemiology and animal experiments, low vitamin D during early life has been proposed as a risk factor for schizophrenia. The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing...
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:74482 2023-05-15T17:42:23+02:00 Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study McGrath, J Saari, K Hakko, H Jokelainen, J Jones, P Jarvelin, MR Chant, D Isohanni, M H. A. Nasrallah L. E. Delisi 2004-01-01 https://espace.library.uq.edu.au/view/UQ:74482 eng eng Elsevier BV doi:10.1016/j.schres.2003.08.005 issn:0920-9964 orcid:0000-0002-4792-6068 Schizophrenia 1,25-dihydroxyvitamin D-3 Brain Growth And Development Northern Finland Seasonal-variation Prenatal Famine Nervous-system Follow-up Body-mass Pregnancy Childhood Brain Psychiatry 321021 Psychiatry C1 730211 Mental health Journal Article 2004 ftunivqespace https://doi.org/10.1016/j.schres.2003.08.005 2020-10-26T23:36:34Z Objective: Based on clues from epidemiology and animal experiments, low vitamin D during early life has been proposed as a risk factor for schizophrenia. The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing schizophrenia. Method: Subjects were drawn from the Northern Finland 1966 Birth Cohort (n = 9 114). During the first year of life, data were collected about the frequency and dose of vitamin D supplementation. Our primary outcome measures were schizophrenia, psychotic disorders other than schizophrenia, and nonpsychotic disorders as diagnosed by age 31 years. Males and females were examined separately. Results: In males, the use of either irregular or regular vitamin D supplements was associated with a reduced risk of schizophrenia (Risk ratio (RR) = 0.08, 95% CI 0.01-0.95; RR = 0.12, 95% CI 0.02-0.90, respectively) compared with no supplementation. In males, the use of at least 2000 IU of vitamin D was associated with a reduced risk of schizophrenia (RR = 0.23, 95% CI 0.06-0.95) compared to those on lower doses. There were no significant associations between either the frequency or dose of vitamin D supplements and (a) schizophrenia in females, nor with (b) nonpsychotic disorder or psychotic disorders other than schizophrenia in either males or females. Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia. (C) 2003 Elsevier B.V. All rights reserved. Article in Journal/Newspaper Northern Finland The University of Queensland: UQ eSpace Schizophrenia Research 67 2-3 237 245 |
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Open Polar |
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The University of Queensland: UQ eSpace |
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ftunivqespace |
language |
English |
topic |
Schizophrenia 1,25-dihydroxyvitamin D-3 Brain Growth And Development Northern Finland Seasonal-variation Prenatal Famine Nervous-system Follow-up Body-mass Pregnancy Childhood Brain Psychiatry 321021 Psychiatry C1 730211 Mental health |
spellingShingle |
Schizophrenia 1,25-dihydroxyvitamin D-3 Brain Growth And Development Northern Finland Seasonal-variation Prenatal Famine Nervous-system Follow-up Body-mass Pregnancy Childhood Brain Psychiatry 321021 Psychiatry C1 730211 Mental health McGrath, J Saari, K Hakko, H Jokelainen, J Jones, P Jarvelin, MR Chant, D Isohanni, M Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
topic_facet |
Schizophrenia 1,25-dihydroxyvitamin D-3 Brain Growth And Development Northern Finland Seasonal-variation Prenatal Famine Nervous-system Follow-up Body-mass Pregnancy Childhood Brain Psychiatry 321021 Psychiatry C1 730211 Mental health |
description |
Objective: Based on clues from epidemiology and animal experiments, low vitamin D during early life has been proposed as a risk factor for schizophrenia. The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing schizophrenia. Method: Subjects were drawn from the Northern Finland 1966 Birth Cohort (n = 9 114). During the first year of life, data were collected about the frequency and dose of vitamin D supplementation. Our primary outcome measures were schizophrenia, psychotic disorders other than schizophrenia, and nonpsychotic disorders as diagnosed by age 31 years. Males and females were examined separately. Results: In males, the use of either irregular or regular vitamin D supplements was associated with a reduced risk of schizophrenia (Risk ratio (RR) = 0.08, 95% CI 0.01-0.95; RR = 0.12, 95% CI 0.02-0.90, respectively) compared with no supplementation. In males, the use of at least 2000 IU of vitamin D was associated with a reduced risk of schizophrenia (RR = 0.23, 95% CI 0.06-0.95) compared to those on lower doses. There were no significant associations between either the frequency or dose of vitamin D supplements and (a) schizophrenia in females, nor with (b) nonpsychotic disorder or psychotic disorders other than schizophrenia in either males or females. Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia. (C) 2003 Elsevier B.V. All rights reserved. |
author2 |
H. A. Nasrallah L. E. Delisi |
format |
Article in Journal/Newspaper |
author |
McGrath, J Saari, K Hakko, H Jokelainen, J Jones, P Jarvelin, MR Chant, D Isohanni, M |
author_facet |
McGrath, J Saari, K Hakko, H Jokelainen, J Jones, P Jarvelin, MR Chant, D Isohanni, M |
author_sort |
McGrath, J |
title |
Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
title_short |
Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
title_full |
Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
title_fullStr |
Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
title_full_unstemmed |
Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study |
title_sort |
vitamin d supplementation during the first year of life and risk of schizophrenia: a finnish birth cohort study |
publisher |
Elsevier BV |
publishDate |
2004 |
url |
https://espace.library.uq.edu.au/view/UQ:74482 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
doi:10.1016/j.schres.2003.08.005 issn:0920-9964 orcid:0000-0002-4792-6068 |
op_doi |
https://doi.org/10.1016/j.schres.2003.08.005 |
container_title |
Schizophrenia Research |
container_volume |
67 |
container_issue |
2-3 |
container_start_page |
237 |
op_container_end_page |
245 |
_version_ |
1766144229293162496 |