The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer
A nitric oxide (NO) and carbon dioxide (CO2) dual-responsive block copolymer was self-assembled in aqueous solution upon gas stimuli to form nanostructures. Specifically, poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(N, N-diethylaminoethyl methacrylate)-block-poly(2-(3-(2-aminoph...
Published in: | Polymer Chemistry |
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Language: | English |
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Royal Society of Chemistry
2015
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:6e9fab3 2023-05-15T15:52:44+02:00 The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer Hu, Jinming Whittaker, Michael R. Li, Yang Quinn, John F. Davis, Thomas P. 2015-01-01 https://espace.library.uq.edu.au/view/UQ:6e9fab3 eng eng Royal Society of Chemistry doi:10.1039/c4py01678e issn:1759-9954 issn:1759-9962 orcid:0000-0003-2581-4986 CE140100036 Nitric-Oxide Biomedical Applications Drug-Delivery Fluorescent-Probe Carbon-Dioxide Polymers Stimuli Nanoparticles Vesicles Systems Journal Article 2015 ftunivqespace https://doi.org/10.1039/c4py01678e 2020-10-27T06:34:47Z A nitric oxide (NO) and carbon dioxide (CO2) dual-responsive block copolymer was self-assembled in aqueous solution upon gas stimuli to form nanostructures. Specifically, poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(N, N-diethylaminoethyl methacrylate)-block-poly(2-(3-(2-aminophenyl)ureido) ethyl methacrylate) (POEGMA-b-PDEAEMA-b-PAPUEMA) (termed ODA) triblock copolymers, consisting of a CO2-responsive PDEAEMA block and a NO-sensitive PAPUEMA block, were synthesized using sequential reversible addition-fragmentation chain transfer (RAFT) polymerization. The ODA triblock copolymer was found to self-assemble at pH 7.4 into three-layer micelles with PAPUEMA inner cores, PDEAEMA outer cores, and hydrophilic POEGMA coronas. Upon CO2 addition, the collapsed PDEAEMA block became protonated, increasing water solubility following the generation of carbonic acid functionality, resulting in the formation of expanded micelles with PAPUEMA cores. Subsequent NO addition selectively transformed the interior PAPUEMA block into more hydrophobic benzotriazole moieties, driving a morphological transition from swollen micelles to nanorods. Importantly, the transformation from spherical nanoparticles to nanorods in this novel copolymer system is highly specific to NO exposure. Article in Journal/Newspaper Carbonic acid The University of Queensland: UQ eSpace Polymer Chemistry 6 13 2407 2415 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Nitric-Oxide Biomedical Applications Drug-Delivery Fluorescent-Probe Carbon-Dioxide Polymers Stimuli Nanoparticles Vesicles Systems |
spellingShingle |
Nitric-Oxide Biomedical Applications Drug-Delivery Fluorescent-Probe Carbon-Dioxide Polymers Stimuli Nanoparticles Vesicles Systems Hu, Jinming Whittaker, Michael R. Li, Yang Quinn, John F. Davis, Thomas P. The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
topic_facet |
Nitric-Oxide Biomedical Applications Drug-Delivery Fluorescent-Probe Carbon-Dioxide Polymers Stimuli Nanoparticles Vesicles Systems |
description |
A nitric oxide (NO) and carbon dioxide (CO2) dual-responsive block copolymer was self-assembled in aqueous solution upon gas stimuli to form nanostructures. Specifically, poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(N, N-diethylaminoethyl methacrylate)-block-poly(2-(3-(2-aminophenyl)ureido) ethyl methacrylate) (POEGMA-b-PDEAEMA-b-PAPUEMA) (termed ODA) triblock copolymers, consisting of a CO2-responsive PDEAEMA block and a NO-sensitive PAPUEMA block, were synthesized using sequential reversible addition-fragmentation chain transfer (RAFT) polymerization. The ODA triblock copolymer was found to self-assemble at pH 7.4 into three-layer micelles with PAPUEMA inner cores, PDEAEMA outer cores, and hydrophilic POEGMA coronas. Upon CO2 addition, the collapsed PDEAEMA block became protonated, increasing water solubility following the generation of carbonic acid functionality, resulting in the formation of expanded micelles with PAPUEMA cores. Subsequent NO addition selectively transformed the interior PAPUEMA block into more hydrophobic benzotriazole moieties, driving a morphological transition from swollen micelles to nanorods. Importantly, the transformation from spherical nanoparticles to nanorods in this novel copolymer system is highly specific to NO exposure. |
format |
Article in Journal/Newspaper |
author |
Hu, Jinming Whittaker, Michael R. Li, Yang Quinn, John F. Davis, Thomas P. |
author_facet |
Hu, Jinming Whittaker, Michael R. Li, Yang Quinn, John F. Davis, Thomas P. |
author_sort |
Hu, Jinming |
title |
The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
title_short |
The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
title_full |
The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
title_fullStr |
The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
title_full_unstemmed |
The use of endogenous gaseous molecules (NO and CO2) to regulate the self-assembly of a dual-responsive triblock copolymer |
title_sort |
use of endogenous gaseous molecules (no and co2) to regulate the self-assembly of a dual-responsive triblock copolymer |
publisher |
Royal Society of Chemistry |
publishDate |
2015 |
url |
https://espace.library.uq.edu.au/view/UQ:6e9fab3 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_relation |
doi:10.1039/c4py01678e issn:1759-9954 issn:1759-9962 orcid:0000-0003-2581-4986 CE140100036 |
op_doi |
https://doi.org/10.1039/c4py01678e |
container_title |
Polymer Chemistry |
container_volume |
6 |
container_issue |
13 |
container_start_page |
2407 |
op_container_end_page |
2415 |
_version_ |
1766387841286275072 |