Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment
The occurrence of the metabolites of five human pharmaceuticals was investigated in treated wastewater, surface waters and sediments. Metabolites of carbamazepine (carbamazepine epoxide), diclofenac (4′- and 5-hydroxy diclofenac) and atorvastatin (o- and p-hydroxy atorvastatin) were typically detect...
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Royal Society of Chemistry
2011
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:676731 2023-05-15T18:34:23+02:00 Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment Langford, Katherine Thomas, Kevin V. 2011-02-01 https://espace.library.uq.edu.au/view/UQ:676731 eng eng Royal Society of Chemistry doi:10.1039/c0em00342e issn:1464-0325 issn:2050-7895 orcid:0000-0002-2155-100X Chemistry Analytical Environmental Sciences Environmental Sciences & Ecology 2308 Management Monitoring Policy and Law 2739 Public Health Environmental and Occupational Health Journal Article 2011 ftunivqespace https://doi.org/10.1039/c0em00342e 2020-12-08T01:58:19Z The occurrence of the metabolites of five human pharmaceuticals was investigated in treated wastewater, surface waters and sediments. Metabolites of carbamazepine (carbamazepine epoxide), diclofenac (4′- and 5-hydroxy diclofenac) and atorvastatin (o- and p-hydroxy atorvastatin) were typically detected in flow proportional 24 h composite samples of wastewater effluent collected from the Norwegian cities of Oslo and Tromsø at higher concentrations than the parent pharmaceutical. The concentrations determined in discharged effluent were as high as 3700 ng L for 5-hydroxy diclofenac. The overall mean concentration of metabolites being typically higher in the primary treated effluent from the city of Tromsø compared to the tertiary treatment performed on the Oslo effluent. Metabolites of carbamazepine (carbamazepine-10,11-epoxide), metoprolol (α-hydroxy metoprolol) and simvastatin (hydroxy simvastatin) were detected in surface water samples collected from Oslofjord at concentrations of up to 108 ng L, whilst α-hydroxy metoprolol and simvastatin hydroxy carboxylic acid were also detected in sediments at low ng L concentrations. These screening data show that the metabolites of selected pharmaceuticals are being discharged into the Norwegian coastal environment and that certain metabolites occur in marine surface waters and sediments. Article in Journal/Newspaper Tromsø The University of Queensland: UQ eSpace Tromsø J. Environ. Monit. 13 2 416 421 |
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Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Chemistry Analytical Environmental Sciences Environmental Sciences & Ecology 2308 Management Monitoring Policy and Law 2739 Public Health Environmental and Occupational Health |
spellingShingle |
Chemistry Analytical Environmental Sciences Environmental Sciences & Ecology 2308 Management Monitoring Policy and Law 2739 Public Health Environmental and Occupational Health Langford, Katherine Thomas, Kevin V. Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
topic_facet |
Chemistry Analytical Environmental Sciences Environmental Sciences & Ecology 2308 Management Monitoring Policy and Law 2739 Public Health Environmental and Occupational Health |
description |
The occurrence of the metabolites of five human pharmaceuticals was investigated in treated wastewater, surface waters and sediments. Metabolites of carbamazepine (carbamazepine epoxide), diclofenac (4′- and 5-hydroxy diclofenac) and atorvastatin (o- and p-hydroxy atorvastatin) were typically detected in flow proportional 24 h composite samples of wastewater effluent collected from the Norwegian cities of Oslo and Tromsø at higher concentrations than the parent pharmaceutical. The concentrations determined in discharged effluent were as high as 3700 ng L for 5-hydroxy diclofenac. The overall mean concentration of metabolites being typically higher in the primary treated effluent from the city of Tromsø compared to the tertiary treatment performed on the Oslo effluent. Metabolites of carbamazepine (carbamazepine-10,11-epoxide), metoprolol (α-hydroxy metoprolol) and simvastatin (hydroxy simvastatin) were detected in surface water samples collected from Oslofjord at concentrations of up to 108 ng L, whilst α-hydroxy metoprolol and simvastatin hydroxy carboxylic acid were also detected in sediments at low ng L concentrations. These screening data show that the metabolites of selected pharmaceuticals are being discharged into the Norwegian coastal environment and that certain metabolites occur in marine surface waters and sediments. |
format |
Article in Journal/Newspaper |
author |
Langford, Katherine Thomas, Kevin V. |
author_facet |
Langford, Katherine Thomas, Kevin V. |
author_sort |
Langford, Katherine |
title |
Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
title_short |
Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
title_full |
Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
title_fullStr |
Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
title_full_unstemmed |
Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment |
title_sort |
input of selected human pharmaceutical metabolites into the norwegian aquatic environment |
publisher |
Royal Society of Chemistry |
publishDate |
2011 |
url |
https://espace.library.uq.edu.au/view/UQ:676731 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
doi:10.1039/c0em00342e issn:1464-0325 issn:2050-7895 orcid:0000-0002-2155-100X |
op_doi |
https://doi.org/10.1039/c0em00342e |
container_title |
J. Environ. Monit. |
container_volume |
13 |
container_issue |
2 |
container_start_page |
416 |
op_container_end_page |
421 |
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1766219108533141504 |