Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications
Death adders (genus Acanthophis) are unique among elapid snakes in both morphology and venom composition. Despite this genus being among the most divergent of all elapids, the venom has been historically regarded as relatively quite simple. In this study, liquid chromatography/mass spectrometry (LC/...
Published in: | Rapid Communications in Mass Spectrometry |
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:63026 2023-05-15T13:54:41+02:00 Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications Fry, B. G. Wickramaratna, J. C. Hodgson, W. C. Alewood, P. F. Kini, R. M. Ho, H. Wuster, W. Bowie, John 2002-01-01 https://espace.library.uq.edu.au/view/UQ:63026 eng eng John Wiley & sons doi:10.1002/rcm.613 issn:0951-4198 orcid:0000-0001-6661-1283 orcid:0000-0001-7454-6522 Chemistry Analytical Spectroscopy Papua-new-guinea Snake-venom Mass-spectrometry Elapid Snakes Antarcticus Praelongus Bite Purification Inhibitors Australia 250300 Organic Chemistry 270000 Biological Sciences C1 780103 Chemical sciences 780105 Biological sciences Journal Article 2002 ftunivqespace https://doi.org/10.1002/rcm.613 2020-09-21T22:25:00Z Death adders (genus Acanthophis) are unique among elapid snakes in both morphology and venom composition. Despite this genus being among the most divergent of all elapids, the venom has been historically regarded as relatively quite simple. In this study, liquid chromatography/mass spectrometry (LC/MS) analysis has revealed a. much greater diversity in venom composition, including the presence of molecules of novel molecular weights that may represent a new class of venom component. Furthermore, significant variation exists between species and populations,, which allow for the LC/MS fingerprinting of each species. Mass profiling of Acanthophis venoms clearly demonstrates the effectiveness of this technique which underpins fundamental studies ranging from chemotaxonomy to drug design. Copyright (C) 2002 John Wiley Sons, Ltd. Article in Journal/Newspaper Antarc* antarcticus The University of Queensland: UQ eSpace Rapid Communications in Mass Spectrometry 16 6 600 608 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Chemistry Analytical Spectroscopy Papua-new-guinea Snake-venom Mass-spectrometry Elapid Snakes Antarcticus Praelongus Bite Purification Inhibitors Australia 250300 Organic Chemistry 270000 Biological Sciences C1 780103 Chemical sciences 780105 Biological sciences |
spellingShingle |
Chemistry Analytical Spectroscopy Papua-new-guinea Snake-venom Mass-spectrometry Elapid Snakes Antarcticus Praelongus Bite Purification Inhibitors Australia 250300 Organic Chemistry 270000 Biological Sciences C1 780103 Chemical sciences 780105 Biological sciences Fry, B. G. Wickramaratna, J. C. Hodgson, W. C. Alewood, P. F. Kini, R. M. Ho, H. Wuster, W. Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
topic_facet |
Chemistry Analytical Spectroscopy Papua-new-guinea Snake-venom Mass-spectrometry Elapid Snakes Antarcticus Praelongus Bite Purification Inhibitors Australia 250300 Organic Chemistry 270000 Biological Sciences C1 780103 Chemical sciences 780105 Biological sciences |
description |
Death adders (genus Acanthophis) are unique among elapid snakes in both morphology and venom composition. Despite this genus being among the most divergent of all elapids, the venom has been historically regarded as relatively quite simple. In this study, liquid chromatography/mass spectrometry (LC/MS) analysis has revealed a. much greater diversity in venom composition, including the presence of molecules of novel molecular weights that may represent a new class of venom component. Furthermore, significant variation exists between species and populations,, which allow for the LC/MS fingerprinting of each species. Mass profiling of Acanthophis venoms clearly demonstrates the effectiveness of this technique which underpins fundamental studies ranging from chemotaxonomy to drug design. Copyright (C) 2002 John Wiley Sons, Ltd. |
author2 |
Bowie, John |
format |
Article in Journal/Newspaper |
author |
Fry, B. G. Wickramaratna, J. C. Hodgson, W. C. Alewood, P. F. Kini, R. M. Ho, H. Wuster, W. |
author_facet |
Fry, B. G. Wickramaratna, J. C. Hodgson, W. C. Alewood, P. F. Kini, R. M. Ho, H. Wuster, W. |
author_sort |
Fry, B. G. |
title |
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
title_short |
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
title_full |
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
title_fullStr |
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
title_full_unstemmed |
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications |
title_sort |
electrospray liquid chromatography/mass spectrometry fingerprinting of acanthophis (death adder) venoms: taxonomic and toxinological implications |
publisher |
John Wiley & sons |
publishDate |
2002 |
url |
https://espace.library.uq.edu.au/view/UQ:63026 |
genre |
Antarc* antarcticus |
genre_facet |
Antarc* antarcticus |
op_relation |
doi:10.1002/rcm.613 issn:0951-4198 orcid:0000-0001-6661-1283 orcid:0000-0001-7454-6522 |
op_doi |
https://doi.org/10.1002/rcm.613 |
container_title |
Rapid Communications in Mass Spectrometry |
container_volume |
16 |
container_issue |
6 |
container_start_page |
600 |
op_container_end_page |
608 |
_version_ |
1766260767197233152 |