A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring ac...
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:401819 2023-05-15T17:59:14+02:00 A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises Weijs, Liesbeth Covaci, Adrian Yang, Raymond S. H. Das, Krishna Blust, Ronny 2011-10-15 https://espace.library.uq.edu.au/view/UQ:401819 eng eng Academic Press doi:10.1016/j.taap.2011.07.020 issn:0041-008X issn:1096-0333 orcid:0000-0002-2399-1711 Harbor porpoises Metabolism PBPK models PCBs Time trends 3004 Pharmacology 3005 Toxicology Journal Article 2011 ftunivqespace https://doi.org/10.1016/j.taap.2011.07.020 2020-09-29T00:37:23Z In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18. years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. Article in Journal/Newspaper Phocoena phocoena The University of Queensland: UQ eSpace Toxicology and Applied Pharmacology 256 2 136 145 |
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Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Harbor porpoises Metabolism PBPK models PCBs Time trends 3004 Pharmacology 3005 Toxicology |
spellingShingle |
Harbor porpoises Metabolism PBPK models PCBs Time trends 3004 Pharmacology 3005 Toxicology Weijs, Liesbeth Covaci, Adrian Yang, Raymond S. H. Das, Krishna Blust, Ronny A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
topic_facet |
Harbor porpoises Metabolism PBPK models PCBs Time trends 3004 Pharmacology 3005 Toxicology |
description |
In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18. years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. |
format |
Article in Journal/Newspaper |
author |
Weijs, Liesbeth Covaci, Adrian Yang, Raymond S. H. Das, Krishna Blust, Ronny |
author_facet |
Weijs, Liesbeth Covaci, Adrian Yang, Raymond S. H. Das, Krishna Blust, Ronny |
author_sort |
Weijs, Liesbeth |
title |
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
title_short |
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
title_full |
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
title_fullStr |
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
title_full_unstemmed |
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises |
title_sort |
non-invasive approach to study lifetime exposure and bioaccumulation of pcbs in protected marine mammals: pbpk modeling in harbor porpoises |
publisher |
Academic Press |
publishDate |
2011 |
url |
https://espace.library.uq.edu.au/view/UQ:401819 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_relation |
doi:10.1016/j.taap.2011.07.020 issn:0041-008X issn:1096-0333 orcid:0000-0002-2399-1711 |
op_doi |
https://doi.org/10.1016/j.taap.2011.07.020 |
container_title |
Toxicology and Applied Pharmacology |
container_volume |
256 |
container_issue |
2 |
container_start_page |
136 |
op_container_end_page |
145 |
_version_ |
1766168008923807744 |