Ancient human genome sequence of an extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20Ã-, we recover 79% of the diploid genome, an amount close to...
Published in: | Nature |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2010
|
Subjects: | |
Online Access: | https://espace.library.uq.edu.au/view/UQ:368336 |
id |
ftunivqespace:oai:espace.library.uq.edu.au:UQ:368336 |
---|---|
record_format |
openpolar |
spelling |
ftunivqespace:oai:espace.library.uq.edu.au:UQ:368336 2023-05-15T16:07:23+02:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten 2010-02-11 https://espace.library.uq.edu.au/view/UQ:368336 eng eng Nature Publishing Group doi:10.1038/nature08835 issn:0028-0836 issn:1476-4687 Multidisciplinary Journal Article 2010 ftunivqespace https://doi.org/10.1038/nature08835 2020-10-27T02:55:31Z We report here the genome sequence of an ancient human. Obtained from 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20Ã-, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Article in Journal/Newspaper eskimo* Greenland inuit permafrost Siberia The University of Queensland: UQ eSpace Greenland Nature 463 7282 757 762 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Multidisciplinary |
spellingShingle |
Multidisciplinary Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Ancient human genome sequence of an extinct Palaeo-Eskimo |
topic_facet |
Multidisciplinary |
description |
We report here the genome sequence of an ancient human. Obtained from 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20Ã-, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Article in Journal/Newspaper |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten |
author_sort |
Rasmussen, Morten |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publisher |
Nature Publishing Group |
publishDate |
2010 |
url |
https://espace.library.uq.edu.au/view/UQ:368336 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit permafrost Siberia |
genre_facet |
eskimo* Greenland inuit permafrost Siberia |
op_relation |
doi:10.1038/nature08835 issn:0028-0836 issn:1476-4687 |
op_doi |
https://doi.org/10.1038/nature08835 |
container_title |
Nature |
container_volume |
463 |
container_issue |
7282 |
container_start_page |
757 |
op_container_end_page |
762 |
_version_ |
1766403498517200896 |