The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits
Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding investigation of its effect on fit...
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:336866 2023-05-15T17:42:46+02:00 The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits Verweij, Karin J. H. Abdellaoui, Abdel Veijola, Juha Sebert, Sylvain Koiranen, Markku Keller, Matthew C. Jarvelin, Marjo-Ritta Zietsch, Brendan .P. Xiong, Momiao 2014-07-25 https://espace.library.uq.edu.au/view/UQ:336866 eng eng Public Library of Science doi:10.1371/journal.pone.0103102 issn:1932-6203 orcid:0000-0003-0274-6140 104781 120315 129269 1114194 75617 QLG1-CT-2000-01643 5R01HL087679-02 1RL1MH083268-01 5R01MH6370602 G0500539 G0600705 GR069224 HEALTH-F4-2007201413 Not set DE120100562 K01 MH085812 NIMH R01 MH100141 R01HL087679 K01MH085812 RL1MH083268 R01MH100141 R01MH063706 General Biochemistry Genetics and Molecular Biology General Agricultural and Biological Sciences General Medicine 1100 Agricultural and Biological Sciences 1300 Biochemistry Journal Article 2014 ftunivqespace https://doi.org/10.1371/journal.pone.0103102 2020-12-15T01:53:10Z Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding investigation of its effect on fitness-relevant traits. Recently, the availability of high-density genotype data has enabled quantification of variation in distant inbreeding in 'outbred' human populations, but the low variance of inbreeding detected from genetic data in most outbred populations means large samples are required to test effects, and only a few traits have yet been studied. However, it is likely that isolated populations, or those with a small effective population size, have higher variation in inbreeding and therefore require smaller sample sizes to detect inbreeding effects. With a small effective population size and low immigration, Northern Finland is such a population. We make use of a sample of ∼5,500 'unrelated' individuals in the Northern Finnish Birth Cohort 1966 with known genotypes and measured phenotypes across a range of fitness-relevant physical and psychological traits, including birth length and adult height, body mass index (BMI), waist-to-hip ratio, blood pressure, heart rate, grip strength, educational attainment, income, marital status, handedness, health, and schizotypal features. We find significant associations in the predicted direction between individuals' inbreeding coefficient (measured by proportion of the genome in runs of homozygosity) and eight of the 18 traits investigated, significantly more than the one or two expected by chance. These results are consistent with inbreeding depression effects on a range of human traits, but further research is needed to replicate and test alternative explanations for these effects. Article in Journal/Newspaper Northern Finland The University of Queensland: UQ eSpace PLoS ONE 9 7 e103102 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
General Biochemistry Genetics and Molecular Biology General Agricultural and Biological Sciences General Medicine 1100 Agricultural and Biological Sciences 1300 Biochemistry |
spellingShingle |
General Biochemistry Genetics and Molecular Biology General Agricultural and Biological Sciences General Medicine 1100 Agricultural and Biological Sciences 1300 Biochemistry Verweij, Karin J. H. Abdellaoui, Abdel Veijola, Juha Sebert, Sylvain Koiranen, Markku Keller, Matthew C. Jarvelin, Marjo-Ritta Zietsch, Brendan .P. The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
topic_facet |
General Biochemistry Genetics and Molecular Biology General Agricultural and Biological Sciences General Medicine 1100 Agricultural and Biological Sciences 1300 Biochemistry |
description |
Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding investigation of its effect on fitness-relevant traits. Recently, the availability of high-density genotype data has enabled quantification of variation in distant inbreeding in 'outbred' human populations, but the low variance of inbreeding detected from genetic data in most outbred populations means large samples are required to test effects, and only a few traits have yet been studied. However, it is likely that isolated populations, or those with a small effective population size, have higher variation in inbreeding and therefore require smaller sample sizes to detect inbreeding effects. With a small effective population size and low immigration, Northern Finland is such a population. We make use of a sample of ∼5,500 'unrelated' individuals in the Northern Finnish Birth Cohort 1966 with known genotypes and measured phenotypes across a range of fitness-relevant physical and psychological traits, including birth length and adult height, body mass index (BMI), waist-to-hip ratio, blood pressure, heart rate, grip strength, educational attainment, income, marital status, handedness, health, and schizotypal features. We find significant associations in the predicted direction between individuals' inbreeding coefficient (measured by proportion of the genome in runs of homozygosity) and eight of the 18 traits investigated, significantly more than the one or two expected by chance. These results are consistent with inbreeding depression effects on a range of human traits, but further research is needed to replicate and test alternative explanations for these effects. |
author2 |
Xiong, Momiao |
format |
Article in Journal/Newspaper |
author |
Verweij, Karin J. H. Abdellaoui, Abdel Veijola, Juha Sebert, Sylvain Koiranen, Markku Keller, Matthew C. Jarvelin, Marjo-Ritta Zietsch, Brendan .P. |
author_facet |
Verweij, Karin J. H. Abdellaoui, Abdel Veijola, Juha Sebert, Sylvain Koiranen, Markku Keller, Matthew C. Jarvelin, Marjo-Ritta Zietsch, Brendan .P. |
author_sort |
Verweij, Karin J. H. |
title |
The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
title_short |
The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
title_full |
The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
title_fullStr |
The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
title_full_unstemmed |
The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
title_sort |
association of genotype-based inbreeding coefficient with a range of physical and psychological human traits |
publisher |
Public Library of Science |
publishDate |
2014 |
url |
https://espace.library.uq.edu.au/view/UQ:336866 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
doi:10.1371/journal.pone.0103102 issn:1932-6203 orcid:0000-0003-0274-6140 104781 120315 129269 1114194 75617 QLG1-CT-2000-01643 5R01HL087679-02 1RL1MH083268-01 5R01MH6370602 G0500539 G0600705 GR069224 HEALTH-F4-2007201413 Not set DE120100562 K01 MH085812 NIMH R01 MH100141 R01HL087679 K01MH085812 RL1MH083268 R01MH100141 R01MH063706 |
op_doi |
https://doi.org/10.1371/journal.pone.0103102 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
7 |
container_start_page |
e103102 |
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1766144690090934272 |