Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step.

Bibliographic Details
Published in:Tetrahedron
Main Authors: Bachu, Prabhakar, Sperry, Jonathan, Brimble, Margaret A.
Format: Article in Journal/Newspaper
Language:English
Published: Pergamon 2008
Subjects:
Eleutherin
Thysanone
Topoisomerase II inhibitor
3C-protease inhibitor
Novozyme 4350 (Candida antarctica lipase)
Microwave assisted lipase kinetic resolution
Intramolecular cyclization
Antarc*
Antarctica
Online Access:https://espace.library.uq.edu.au/view/UQ:270765
id ftunivqespace:oai:espace.library.uq.edu.au:UQ:270765
record_format openpolar
spelling ftunivqespace:oai:espace.library.uq.edu.au:UQ:270765 2023-05-15T13:31:00+02:00 Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone Bachu, Prabhakar Sperry, Jonathan Brimble, Margaret A. 2008-05-01 https://espace.library.uq.edu.au/view/UQ:270765 eng eng Pergamon doi:10.1016/j.tet.2008.01.112 issn:0040-4020 issn:1464-5416 Eleutherin Thysanone Topoisomerase II inhibitor 3C-protease inhibitor Novozyme 4350 (Candida antarctica lipase) Microwave assisted lipase kinetic resolution Intramolecular cyclization Journal Article 2008 ftunivqespace https://doi.org/10.1016/j.tet.2008.01.112 2020-08-05T02:29:57Z The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step. Article in Journal/Newspaper Antarc* Antarctica The University of Queensland: UQ eSpace Tetrahedron 64 21 4827 4834
institution Open Polar
collection The University of Queensland: UQ eSpace
op_collection_id ftunivqespace
language English
topic Eleutherin
Thysanone
Topoisomerase II inhibitor
3C-protease inhibitor
Novozyme 4350 (Candida antarctica lipase)
Microwave assisted lipase kinetic resolution
Intramolecular cyclization
spellingShingle Eleutherin
Thysanone
Topoisomerase II inhibitor
3C-protease inhibitor
Novozyme 4350 (Candida antarctica lipase)
Microwave assisted lipase kinetic resolution
Intramolecular cyclization
Bachu, Prabhakar
Sperry, Jonathan
Brimble, Margaret A.
Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
topic_facet Eleutherin
Thysanone
Topoisomerase II inhibitor
3C-protease inhibitor
Novozyme 4350 (Candida antarctica lipase)
Microwave assisted lipase kinetic resolution
Intramolecular cyclization
description The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step.
format Article in Journal/Newspaper
author Bachu, Prabhakar
Sperry, Jonathan
Brimble, Margaret A.
author_facet Bachu, Prabhakar
Sperry, Jonathan
Brimble, Margaret A.
author_sort Bachu, Prabhakar
title Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
title_short Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
title_full Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
title_fullStr Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
title_full_unstemmed Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
title_sort chemoenzymatic synthesis of deoxy analogues of the dna topoisomerase ii inhibitor eleutherin and the 3c-protease inhibitor thysanone
publisher Pergamon
publishDate 2008
url https://espace.library.uq.edu.au/view/UQ:270765
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation doi:10.1016/j.tet.2008.01.112
issn:0040-4020
issn:1464-5416
op_doi https://doi.org/10.1016/j.tet.2008.01.112
container_title Tetrahedron
container_volume 64
container_issue 21
container_start_page 4827
op_container_end_page 4834
_version_ 1766014850311389184

Similar Items