A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution
The major histocompatibility complex (MHC) has an integral role in the immune system, and hence diversity at its genes may be of particular importance for the health of populations. In large populations, balancing selection maintains diversity in MHC genes, but theoretical expectations indicate that...
Published in: | Proceedings of the Royal Society of London. Series B: Biological Sciences |
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2004
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Online Access: | https://espace.library.uq.edu.au/view/UQ:117440 |
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ftunivqespace:oai:espace.library.uq.edu.au:UQ:117440 2023-05-15T15:49:50+02:00 A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution Seddon, J. M. Ellegren, H. 2004-11-07 https://espace.library.uq.edu.au/view/UQ:117440 eng eng Royal Society London doi:10.1098/rspb.2004.2869 issn:0962-8452 orcid:0000-0003-3789-6878 Biology DRB1 DQA DQB1 balancing selection wolf Canis lupus Canis-lupus Associative Overdominance Natural-selection European Wolves Mating Patterns Mhc Polymorphism Vertebrates Variability 06 Biological Sciences Journal Article 2004 ftunivqespace https://doi.org/10.1098/rspb.2004.2869 2020-08-04T06:53:28Z The major histocompatibility complex (MHC) has an integral role in the immune system, and hence diversity at its genes may be of particular importance for the health of populations. In large populations, balancing selection maintains diversity in MHC genes, but theoretical expectations indicate that this form of selection is absent or inefficient in small populations. We examine the level of diversity at three MHC class II loci in the wolf population of Scandinavia, a population naturally recolonized with a genetic contribution from as few as three founders, and in four neighbouring wolf populations. In the Scandinavian wolf population, two alleles were found for each locus and the distribution of alleles is compatible with their linkage into two haplotypes. Changes in the level of heterozygosity over time since recolonization demonstrate the effects of the proposed arrival of an immigrant wolf. The maintenance of diversity is shown to be compatible with a neutral, random allocation of alleles, in conjunction with crossing between packs. A total of 15 DPB1, seven DQA and 10 DQB1 alleles are found in four neighbouring wolf populations, with substantial sharing across populations. Even in these larger populations, bottlenecks and fragmentation with consequent genetic drift are likely to have resulted in few indicators for balancing selection and significant differentiation of populations. Article in Journal/Newspaper Canis lupus The University of Queensland: UQ eSpace Proceedings of the Royal Society of London. Series B: Biological Sciences 271 1554 2283 2291 |
institution |
Open Polar |
collection |
The University of Queensland: UQ eSpace |
op_collection_id |
ftunivqespace |
language |
English |
topic |
Biology DRB1 DQA DQB1 balancing selection wolf Canis lupus Canis-lupus Associative Overdominance Natural-selection European Wolves Mating Patterns Mhc Polymorphism Vertebrates Variability 06 Biological Sciences |
spellingShingle |
Biology DRB1 DQA DQB1 balancing selection wolf Canis lupus Canis-lupus Associative Overdominance Natural-selection European Wolves Mating Patterns Mhc Polymorphism Vertebrates Variability 06 Biological Sciences Seddon, J. M. Ellegren, H. A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
topic_facet |
Biology DRB1 DQA DQB1 balancing selection wolf Canis lupus Canis-lupus Associative Overdominance Natural-selection European Wolves Mating Patterns Mhc Polymorphism Vertebrates Variability 06 Biological Sciences |
description |
The major histocompatibility complex (MHC) has an integral role in the immune system, and hence diversity at its genes may be of particular importance for the health of populations. In large populations, balancing selection maintains diversity in MHC genes, but theoretical expectations indicate that this form of selection is absent or inefficient in small populations. We examine the level of diversity at three MHC class II loci in the wolf population of Scandinavia, a population naturally recolonized with a genetic contribution from as few as three founders, and in four neighbouring wolf populations. In the Scandinavian wolf population, two alleles were found for each locus and the distribution of alleles is compatible with their linkage into two haplotypes. Changes in the level of heterozygosity over time since recolonization demonstrate the effects of the proposed arrival of an immigrant wolf. The maintenance of diversity is shown to be compatible with a neutral, random allocation of alleles, in conjunction with crossing between packs. A total of 15 DPB1, seven DQA and 10 DQB1 alleles are found in four neighbouring wolf populations, with substantial sharing across populations. Even in these larger populations, bottlenecks and fragmentation with consequent genetic drift are likely to have resulted in few indicators for balancing selection and significant differentiation of populations. |
format |
Article in Journal/Newspaper |
author |
Seddon, J. M. Ellegren, H. |
author_facet |
Seddon, J. M. Ellegren, H. |
author_sort |
Seddon, J. M. |
title |
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
title_short |
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
title_full |
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
title_fullStr |
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
title_full_unstemmed |
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution |
title_sort |
temporal analysis shows major histocompatibility complex loci in the scandinavian wolf population are consistent with neutral evolution |
publisher |
Royal Society London |
publishDate |
2004 |
url |
https://espace.library.uq.edu.au/view/UQ:117440 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
doi:10.1098/rspb.2004.2869 issn:0962-8452 orcid:0000-0003-3789-6878 |
op_doi |
https://doi.org/10.1098/rspb.2004.2869 |
container_title |
Proceedings of the Royal Society of London. Series B: Biological Sciences |
container_volume |
271 |
container_issue |
1554 |
container_start_page |
2283 |
op_container_end_page |
2291 |
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1766384853465432064 |