Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study
[EN] High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality....
Published in: | Psychiatry Research: Neuroimaging |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
2017
|
Subjects: | |
Online Access: | http://hdl.handle.net/10251/154106 https://doi.org/10.1016/j.pscychresns.2017.05.009 |
id |
ftunivpvalencia:oai:riunet.upv.es:10251/154106 |
---|---|
record_format |
openpolar |
institution |
Open Polar |
collection |
Politechnical University of Valencia: RiuNet |
op_collection_id |
ftunivpvalencia |
language |
English |
topic |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI FISICA APLICADA |
spellingShingle |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI FISICA APLICADA Huhtaniska, Sanna Jaaskelainen, Erika Heikka, Tuomas Moilanen, Jani S. Lehtiniemi, Heli Tohka, Jussi Manjón Herrera, José Vicente Coupe, Pierrick Bjornholm, Lassi Koponen, Hannu Veijola, Juha Isohanni, Matti Kiviniemi, Vesa Murray, Graham K. Miettunen, Jouko Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
topic_facet |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI FISICA APLICADA |
description |
[EN] High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning. This study was supported by the University of Oulu Scholarship Foundation, the Jalmari and Rauha Ahokas foundation, the Orion Research Foundation sr, the Scholarship Fund of the University of Ouu - Tyyni Tani Found, the Foundation for Psychiatric Research, the Sigrid Juselius Foundation, the Academy of Finland (#132071, #268336 and #278286), the Brain & Behavior Research Foundation, Northern Finland Health Care Support Foundation, the Universidad Carlos III de Madrid, the European Union's Seventh Framework Programme for Research, Technological Development and Demonstration under Grant agreement no. 600371, el Ministerio de ... |
author2 |
Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada Banco Santander Academy of Finland University of Oulu Orion Research Foundation Sigrid Jusélius Foundation Universidad Carlos III de Madrid Jalmari and Rauha Ahokas Foundation Brain and Behavior Research Foundation Ministerio de Economía y Competitividad Ministerio de Educación, Cultura y Deporte |
format |
Article in Journal/Newspaper |
author |
Huhtaniska, Sanna Jaaskelainen, Erika Heikka, Tuomas Moilanen, Jani S. Lehtiniemi, Heli Tohka, Jussi Manjón Herrera, José Vicente Coupe, Pierrick Bjornholm, Lassi Koponen, Hannu Veijola, Juha Isohanni, Matti Kiviniemi, Vesa Murray, Graham K. Miettunen, Jouko |
author_facet |
Huhtaniska, Sanna Jaaskelainen, Erika Heikka, Tuomas Moilanen, Jani S. Lehtiniemi, Heli Tohka, Jussi Manjón Herrera, José Vicente Coupe, Pierrick Bjornholm, Lassi Koponen, Hannu Veijola, Juha Isohanni, Matti Kiviniemi, Vesa Murray, Graham K. Miettunen, Jouko |
author_sort |
Huhtaniska, Sanna |
title |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_short |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_full |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_fullStr |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_full_unstemmed |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_sort |
long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: the northern finland birth cohort 1966 study |
publisher |
Elsevier |
publishDate |
2017 |
url |
http://hdl.handle.net/10251/154106 https://doi.org/10.1016/j.pscychresns.2017.05.009 |
long_lat |
ENVELOPE(-59.800,-59.800,-62.438,-62.438) ENVELOPE(-64.233,-64.233,-64.250,-64.250) |
geographic |
Orion Sigrid |
geographic_facet |
Orion Sigrid |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
MINECO/COFUND2013-40258 Psychiatry Research Neuroimaging info:eu-repo/grantAgreement/AKA//132071/FI/Lifespan development of schizophrenic psychoses within the Northern Finland 1966 Birth Cohort/ info:eu-repo/grantAgreement/EC/FP7/600371/EU/CONnecting EXcellence to UC3M/ info:eu-repo/grantAgreement/MINECO//COFUND2013-40259/ info:eu-repo/grantAgreement/AKA//278286/FI/Exploring longitudinal course and outcomes in schizophrenia at 20-year interval - the Northern Finland Birth Cohorts 1966 and 1986/ info:eu-repo/grantAgreement/AKA//268336/FI/Trends and interactions of risk factors of psychotic disorders - Northern Finland Birth Cohort studies 1966 and 1986/ info:eu-repo/grantAgreement/MECD//CEI-15-17/ https://doi.org/10.1016/j.pscychresns.2017.05.009 urn:issn:0925-4927 http://hdl.handle.net/10251/154106 doi:10.1016/j.pscychresns.2017.05.009 28618327 |
op_rights |
http://rightsstatements.org/vocab/InC/1.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.pscychresns.2017.05.009 |
container_title |
Psychiatry Research: Neuroimaging |
container_volume |
266 |
container_start_page |
73 |
op_container_end_page |
82 |
_version_ |
1766144106716725248 |
spelling |
ftunivpvalencia:oai:riunet.upv.es:10251/154106 2023-05-15T17:42:16+02:00 Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study Huhtaniska, Sanna Jaaskelainen, Erika Heikka, Tuomas Moilanen, Jani S. Lehtiniemi, Heli Tohka, Jussi Manjón Herrera, José Vicente Coupe, Pierrick Bjornholm, Lassi Koponen, Hannu Veijola, Juha Isohanni, Matti Kiviniemi, Vesa Murray, Graham K. Miettunen, Jouko Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada Banco Santander Academy of Finland University of Oulu Orion Research Foundation Sigrid Jusélius Foundation Universidad Carlos III de Madrid Jalmari and Rauha Ahokas Foundation Brain and Behavior Research Foundation Ministerio de Economía y Competitividad Ministerio de Educación, Cultura y Deporte 2017-08-30 http://hdl.handle.net/10251/154106 https://doi.org/10.1016/j.pscychresns.2017.05.009 eng eng Elsevier MINECO/COFUND2013-40258 Psychiatry Research Neuroimaging info:eu-repo/grantAgreement/AKA//132071/FI/Lifespan development of schizophrenic psychoses within the Northern Finland 1966 Birth Cohort/ info:eu-repo/grantAgreement/EC/FP7/600371/EU/CONnecting EXcellence to UC3M/ info:eu-repo/grantAgreement/MINECO//COFUND2013-40259/ info:eu-repo/grantAgreement/AKA//278286/FI/Exploring longitudinal course and outcomes in schizophrenia at 20-year interval - the Northern Finland Birth Cohorts 1966 and 1986/ info:eu-repo/grantAgreement/AKA//268336/FI/Trends and interactions of risk factors of psychotic disorders - Northern Finland Birth Cohort studies 1966 and 1986/ info:eu-repo/grantAgreement/MECD//CEI-15-17/ https://doi.org/10.1016/j.pscychresns.2017.05.009 urn:issn:0925-4927 http://hdl.handle.net/10251/154106 doi:10.1016/j.pscychresns.2017.05.009 28618327 http://rightsstatements.org/vocab/InC/1.0/ info:eu-repo/semantics/openAccess Schizophrenia Antipsychotics Benzodiazepines Brain MRI FISICA APLICADA info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2017 ftunivpvalencia https://doi.org/10.1016/j.pscychresns.2017.05.009 2022-06-12T20:54:35Z [EN] High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning. This study was supported by the University of Oulu Scholarship Foundation, the Jalmari and Rauha Ahokas foundation, the Orion Research Foundation sr, the Scholarship Fund of the University of Ouu - Tyyni Tani Found, the Foundation for Psychiatric Research, the Sigrid Juselius Foundation, the Academy of Finland (#132071, #268336 and #278286), the Brain & Behavior Research Foundation, Northern Finland Health Care Support Foundation, the Universidad Carlos III de Madrid, the European Union's Seventh Framework Programme for Research, Technological Development and Demonstration under Grant agreement no. 600371, el Ministerio de ... Article in Journal/Newspaper Northern Finland Politechnical University of Valencia: RiuNet Orion ENVELOPE(-59.800,-59.800,-62.438,-62.438) Sigrid ENVELOPE(-64.233,-64.233,-64.250,-64.250) Psychiatry Research: Neuroimaging 266 73 82 |