In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern
Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its e ects on birth outcomes and possible synergistic e ects between Al, essential and neurotoxi...
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Online Access: | http://hdl.handle.net/2263/76594 https://doi.org/10.3390/ijerph17051724 |
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ftunivpretoria:oai:repository.up.ac.za:2263/76594 2023-05-15T13:21:37+02:00 In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern Rollin, Halina B. Channa, Kalavati Olutola, Bukola Ganiyat Nogueira, Claudina Odland, Jon Oyvind 2020-03-06 http://hdl.handle.net/2263/76594 https://doi.org/10.3390/ijerph17051724 en eng MDPI Publishing http://hdl.handle.net/2263/76594 Rollin, H.B., Channa, K., Olutola, B. et al. 2020, 'In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern', International Journal of Environmental Research and Public Health, vol. 17, art. 1724, pp. 1-17. 1660-4601 (online) doi:10.3390/ijerph17051724 © 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. CC-BY Aluminium In utero exposure Birth outcomes Essential trace elements Neurotoxic elements Sex-dependent response to toxicants South Africa (SA) Women Article 2020 ftunivpretoria https://doi.org/10.3390/ijerph17051724 2022-05-31T13:15:20Z Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its e ects on birth outcomes and possible synergistic e ects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coe cients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities. The National Research Foundation (NRF), South Africa, the Research Council of Norway, the Arctic Monitoring and Assessment Programme (AMAP) and the Norwegian Royal Ministry for Foreign Affairs. http://www.mdpi.com/journal/ijerph am2020 School of Health Systems and Public Health (SHSPH) Article in Journal/Newspaper AMAP Arctic University of Pretoria: UPSpace Arctic Norway Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) International Journal of Environmental Research and Public Health 17 5 1724 |
institution |
Open Polar |
collection |
University of Pretoria: UPSpace |
op_collection_id |
ftunivpretoria |
language |
English |
topic |
Aluminium In utero exposure Birth outcomes Essential trace elements Neurotoxic elements Sex-dependent response to toxicants South Africa (SA) Women |
spellingShingle |
Aluminium In utero exposure Birth outcomes Essential trace elements Neurotoxic elements Sex-dependent response to toxicants South Africa (SA) Women Rollin, Halina B. Channa, Kalavati Olutola, Bukola Ganiyat Nogueira, Claudina Odland, Jon Oyvind In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
topic_facet |
Aluminium In utero exposure Birth outcomes Essential trace elements Neurotoxic elements Sex-dependent response to toxicants South Africa (SA) Women |
description |
Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its e ects on birth outcomes and possible synergistic e ects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coe cients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities. The National Research Foundation (NRF), South Africa, the Research Council of Norway, the Arctic Monitoring and Assessment Programme (AMAP) and the Norwegian Royal Ministry for Foreign Affairs. http://www.mdpi.com/journal/ijerph am2020 School of Health Systems and Public Health (SHSPH) |
format |
Article in Journal/Newspaper |
author |
Rollin, Halina B. Channa, Kalavati Olutola, Bukola Ganiyat Nogueira, Claudina Odland, Jon Oyvind |
author_facet |
Rollin, Halina B. Channa, Kalavati Olutola, Bukola Ganiyat Nogueira, Claudina Odland, Jon Oyvind |
author_sort |
Rollin, Halina B. |
title |
In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
title_short |
In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
title_full |
In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
title_fullStr |
In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
title_full_unstemmed |
In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern |
title_sort |
in utero exposure to aluminium and other neurotoxic elements in urban coastal south african women at delivery : an emerging concern |
publisher |
MDPI Publishing |
publishDate |
2020 |
url |
http://hdl.handle.net/2263/76594 https://doi.org/10.3390/ijerph17051724 |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Arctic Norway Rho |
geographic_facet |
Arctic Norway Rho |
genre |
AMAP Arctic |
genre_facet |
AMAP Arctic |
op_relation |
http://hdl.handle.net/2263/76594 Rollin, H.B., Channa, K., Olutola, B. et al. 2020, 'In utero exposure to aluminium and other neurotoxic elements in urban coastal South African women at delivery : an emerging concern', International Journal of Environmental Research and Public Health, vol. 17, art. 1724, pp. 1-17. 1660-4601 (online) doi:10.3390/ijerph17051724 |
op_rights |
© 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/ijerph17051724 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
17 |
container_issue |
5 |
container_start_page |
1724 |
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1766360605871046656 |