Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment
BACKGROUND : Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis. OBJECTI...
Published in: | Environmental Health Perspectives |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
National Institute of Environmental Health Sciences
2017
|
Subjects: | |
Online Access: | http://hdl.handle.net/2263/58771 https://doi.org/10.1289/EHP152 |
id |
ftunivpretoria:oai:repository.up.ac.za:2263/58771 |
---|---|
record_format |
openpolar |
spelling |
ftunivpretoria:oai:repository.up.ac.za:2263/58771 2023-05-15T15:15:11+02:00 Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment Berg, Vivian Nost, Therese Haugdahl Pettersen, Rolf Dagfinn Hansen, Solrunn Veyhe, Anna-Sofia Jorde, Rolf Odland, Jon Oyvind Sandanger, Torkjel Manning 2017-01 http://hdl.handle.net/2263/58771 https://doi.org/10.1289/EHP152 en eng National Institute of Environmental Health Sciences http://hdl.handle.net/2263/58771 0091-6765 (print) 1552-9924 (online) doi:10.1289/EHP152 National Institute of Environmental Health Sciences (NIEHS) Infant Mother Thyroid hormones Persistent organic pollutant (POP) Thyroid-stimulating hormone (TSH) Thyroid hormone (TH) Article 2017 ftunivpretoria https://doi.org/10.1289/EHP152 2022-05-31T13:12:07Z BACKGROUND : Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis. OBJECTIVES : We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Motherand- Child Contaminant Cohort Study (MISA). METHODS : Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA). RESULTS : Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile. CONCLUSION : The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function. The Northern Norway Regional Health Authority, the EU project ArcRisk, The Arctic Monitoring and Assessment Programme and The Research ... Article in Journal/Newspaper Arctic Northern Norway University of Pretoria: UPSpace Arctic Norway Environmental Health Perspectives 125 1 127 133 |
institution |
Open Polar |
collection |
University of Pretoria: UPSpace |
op_collection_id |
ftunivpretoria |
language |
English |
topic |
Infant Mother Thyroid hormones Persistent organic pollutant (POP) Thyroid-stimulating hormone (TSH) Thyroid hormone (TH) |
spellingShingle |
Infant Mother Thyroid hormones Persistent organic pollutant (POP) Thyroid-stimulating hormone (TSH) Thyroid hormone (TH) Berg, Vivian Nost, Therese Haugdahl Pettersen, Rolf Dagfinn Hansen, Solrunn Veyhe, Anna-Sofia Jorde, Rolf Odland, Jon Oyvind Sandanger, Torkjel Manning Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
topic_facet |
Infant Mother Thyroid hormones Persistent organic pollutant (POP) Thyroid-stimulating hormone (TSH) Thyroid hormone (TH) |
description |
BACKGROUND : Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis. OBJECTIVES : We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Motherand- Child Contaminant Cohort Study (MISA). METHODS : Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA). RESULTS : Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile. CONCLUSION : The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function. The Northern Norway Regional Health Authority, the EU project ArcRisk, The Arctic Monitoring and Assessment Programme and The Research ... |
format |
Article in Journal/Newspaper |
author |
Berg, Vivian Nost, Therese Haugdahl Pettersen, Rolf Dagfinn Hansen, Solrunn Veyhe, Anna-Sofia Jorde, Rolf Odland, Jon Oyvind Sandanger, Torkjel Manning |
author_facet |
Berg, Vivian Nost, Therese Haugdahl Pettersen, Rolf Dagfinn Hansen, Solrunn Veyhe, Anna-Sofia Jorde, Rolf Odland, Jon Oyvind Sandanger, Torkjel Manning |
author_sort |
Berg, Vivian |
title |
Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
title_short |
Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
title_full |
Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
title_fullStr |
Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
title_full_unstemmed |
Persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
title_sort |
persistent organic pollutants and the association with maternal and infant thyroid homeostasis : a multipollutant assessment |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2017 |
url |
http://hdl.handle.net/2263/58771 https://doi.org/10.1289/EHP152 |
geographic |
Arctic Norway |
geographic_facet |
Arctic Norway |
genre |
Arctic Northern Norway |
genre_facet |
Arctic Northern Norway |
op_relation |
http://hdl.handle.net/2263/58771 0091-6765 (print) 1552-9924 (online) doi:10.1289/EHP152 |
op_rights |
National Institute of Environmental Health Sciences (NIEHS) |
op_doi |
https://doi.org/10.1289/EHP152 |
container_title |
Environmental Health Perspectives |
container_volume |
125 |
container_issue |
1 |
container_start_page |
127 |
op_container_end_page |
133 |
_version_ |
1766345568361119744 |