Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis
Leptospirosis is a bacterial zoonosis of major concern on tropical islands. Human populations on western Indian Ocean islands are strongly affected by the disease although each archipelago shows contrasting epidemiology. For instance, Mayotte, part of the Comoros Archipelago, differs from the other...
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ftunivpretoria:oai:repository.up.ac.za:2263/57326 2023-05-15T18:05:12+02:00 Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis Lagadec, Erwan Gomard, Yann Le Minter, Gildas Cordonin, Colette Cardinale, Eric Ramasindrazana, Beza Dietrich, Muriel Goodman, Steven M. Tortosa, Pablo Dellagi, Koussay 2016-08-30 http://hdl.handle.net/2263/57326 https://doi.org/10.1371/journal.pntd.0004933 en eng Public Library of Science http://hdl.handle.net/2263/57326 1935-2727 (print) 1935-2735 (online) doi:10.1371/journal.pntd.0004933 © 2016 Lagadec et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. CC-BY Leptospirosis Tropical islands Humans Madagascar Article 2016 ftunivpretoria https://doi.org/10.1371/journal.pntd.0004933 2022-05-31T13:37:16Z Leptospirosis is a bacterial zoonosis of major concern on tropical islands. Human populations on western Indian Ocean islands are strongly affected by the disease although each archipelago shows contrasting epidemiology. For instance, Mayotte, part of the Comoros Archipelago, differs from the other neighbouring islands by a high diversity of Leptospira species infecting humans that includes Leptospira mayottensis, a species thought to be unique to this island. Using bacterial culture, molecular detection and typing, the present study explored the wild and domestic local mammalian fauna for renal carriage of leptospires and addressed the genetic relationships of the infecting strains with local isolates obtained from acute human cases and with Leptospira strains hosted by mammal species endemic to nearby Madagascar. Tenrec (Tenrec ecaudatus, Family Tenrecidae), a terrestrial mammal introduced from Madagascar, is identified as a reservoir of L. mayottensis. All isolated L. mayottensis sequence types form a monophyletic clade that includes Leptospira strains infecting humans and tenrecs on Mayotte, as well as two other Malagasy endemic tenrecid species of the genus Microgale. The lower diversity of L. mayottensis in tenrecs from Mayotte, compared to that occurring in Madagascar, suggests that L. mayottensis has indeed a Malagasy origin. This study also showed that introduced rats (Rattus rattus) and dogs are probably the main reservoirs of Leptospira borgpetersenii and Leptospira kirschneri, both bacteria being prevalent in local clinical cases. Data emphasize the epidemiological link between the two neighbouring islands and the role of introduced small mammals in shaping the local epidemiology of leptospirosis. S1 Fig. Distribution of small mammals sampling sites on Mayotte. Numbers correspond to the 18 sampling sites where Rattus rattus and Tenrec ecaudatus (white) and bats (orange) were trapped. Map was created with QGIS 2.8.1 (QGIS Development Team, 2016, QGIS Geographic Information System, Open Source ... Article in Journal/Newspaper Rattus rattus University of Pretoria: UPSpace Indian PLOS Neglected Tropical Diseases 10 8 e0004933 |
institution |
Open Polar |
collection |
University of Pretoria: UPSpace |
op_collection_id |
ftunivpretoria |
language |
English |
topic |
Leptospirosis Tropical islands Humans Madagascar |
spellingShingle |
Leptospirosis Tropical islands Humans Madagascar Lagadec, Erwan Gomard, Yann Le Minter, Gildas Cordonin, Colette Cardinale, Eric Ramasindrazana, Beza Dietrich, Muriel Goodman, Steven M. Tortosa, Pablo Dellagi, Koussay Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
topic_facet |
Leptospirosis Tropical islands Humans Madagascar |
description |
Leptospirosis is a bacterial zoonosis of major concern on tropical islands. Human populations on western Indian Ocean islands are strongly affected by the disease although each archipelago shows contrasting epidemiology. For instance, Mayotte, part of the Comoros Archipelago, differs from the other neighbouring islands by a high diversity of Leptospira species infecting humans that includes Leptospira mayottensis, a species thought to be unique to this island. Using bacterial culture, molecular detection and typing, the present study explored the wild and domestic local mammalian fauna for renal carriage of leptospires and addressed the genetic relationships of the infecting strains with local isolates obtained from acute human cases and with Leptospira strains hosted by mammal species endemic to nearby Madagascar. Tenrec (Tenrec ecaudatus, Family Tenrecidae), a terrestrial mammal introduced from Madagascar, is identified as a reservoir of L. mayottensis. All isolated L. mayottensis sequence types form a monophyletic clade that includes Leptospira strains infecting humans and tenrecs on Mayotte, as well as two other Malagasy endemic tenrecid species of the genus Microgale. The lower diversity of L. mayottensis in tenrecs from Mayotte, compared to that occurring in Madagascar, suggests that L. mayottensis has indeed a Malagasy origin. This study also showed that introduced rats (Rattus rattus) and dogs are probably the main reservoirs of Leptospira borgpetersenii and Leptospira kirschneri, both bacteria being prevalent in local clinical cases. Data emphasize the epidemiological link between the two neighbouring islands and the role of introduced small mammals in shaping the local epidemiology of leptospirosis. S1 Fig. Distribution of small mammals sampling sites on Mayotte. Numbers correspond to the 18 sampling sites where Rattus rattus and Tenrec ecaudatus (white) and bats (orange) were trapped. Map was created with QGIS 2.8.1 (QGIS Development Team, 2016, QGIS Geographic Information System, Open Source ... |
format |
Article in Journal/Newspaper |
author |
Lagadec, Erwan Gomard, Yann Le Minter, Gildas Cordonin, Colette Cardinale, Eric Ramasindrazana, Beza Dietrich, Muriel Goodman, Steven M. Tortosa, Pablo Dellagi, Koussay |
author_facet |
Lagadec, Erwan Gomard, Yann Le Minter, Gildas Cordonin, Colette Cardinale, Eric Ramasindrazana, Beza Dietrich, Muriel Goodman, Steven M. Tortosa, Pablo Dellagi, Koussay |
author_sort |
Lagadec, Erwan |
title |
Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
title_short |
Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
title_full |
Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
title_fullStr |
Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
title_full_unstemmed |
Identification of Tenrec ecaudatus, a wild mammal Introduced to Mayotte Island, as a reservoir of the newly identified human pathogenic Leptospira mayottensis |
title_sort |
identification of tenrec ecaudatus, a wild mammal introduced to mayotte island, as a reservoir of the newly identified human pathogenic leptospira mayottensis |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
http://hdl.handle.net/2263/57326 https://doi.org/10.1371/journal.pntd.0004933 |
geographic |
Indian |
geographic_facet |
Indian |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://hdl.handle.net/2263/57326 1935-2727 (print) 1935-2735 (online) doi:10.1371/journal.pntd.0004933 |
op_rights |
© 2016 Lagadec et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0004933 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
8 |
container_start_page |
e0004933 |
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1766176651778981888 |