Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa
BACKGROUND The impact of prenatal exposure to cadmium (Cd) on birth outcomes is an area of concern. This study aimed to assess an impact of prenatal Cd exposure on birth outcomes in distinct coastal populations of South Africa. METHODS Cadmium was measured in maternal blood (CdB) (n = 641), cord blo...
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ftunivpretoria:oai:repository.up.ac.za:2263/51764 2023-05-15T13:21:37+02:00 Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa Rollin, Halina B. Kootbodien, Tahira Channa, Kalavati Odland, Jon Oyvind 2015-11-06 http://hdl.handle.net/2263/51764 https://doi.org/10.1371/journal.pone.0142455 en eng Public Library of Science http://hdl.handle.net/2263/51764 Röllin HB, Kootbodien T, Channa K, Odland JØ (2015) Prenatal Exposure to Cadmium, Placental Permeability and Birth Outcomes in Coastal Populations of South Africa. PLoS ONE 10(11): e0142455. DOI:10.1371/journal.pone.0142455. 1932-6203 doi:10.1371/journal.pone.0142455 © 2015 Röllin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. CC-BY Prenatal exposure Birth South Africa (SA) Cadmium (Cd) Placental permeability Article 2015 ftunivpretoria https://doi.org/10.1371/journal.pone.0142455 2022-05-31T10:47:53Z BACKGROUND The impact of prenatal exposure to cadmium (Cd) on birth outcomes is an area of concern. This study aimed to assess an impact of prenatal Cd exposure on birth outcomes in distinct coastal populations of South Africa. METHODS Cadmium was measured in maternal blood (CdB) (n = 641), cord blood and in maternal urine (n = 317). This investigation assessed the associations between CdB (non-transformed) and birth outcomes across the 25th, 50th, and 75th percentile for birth weight, birth length and head circumference, to test for a linear trend. Associations between natural log-transformed maternal CdB, size at birth and other factors were further evaluated using linear mixed-effects modelling with random intercepts. RESULTS The average gestational age in the total sample was 38 weeks; 47% of neonates were female, average birth weight was 3065 g and 11% were of low birth weight (< 2500 g). The geometric mean (GM) of the maternal CdB level was 0.25 μg/L (n = 641; 95% CI, 0.23– 0.27). The cord blood Cd level was 0.27 μg/L (n = 317; 95% CI, 0.26–0.29) and urine (creatinine- corrected) Cd level was 0.27 μg/L (n = 318; 95% CI, 0.24–0.29). The CdB cord:maternal ratio in the sub-cohort was 1, suggesting that the placenta offers no protective mechanism to the foetus. An inverse association was found between CdB and the lower birth weight percentile in female neonates only (β = - 0.13, p = 0.047). Mothers who reported eating vine vegetables daily had lower levels of CdB (β = - 0.55, p = 0.025). Maternal smoking was associated with an elevation in natural log-transformed CdB levels in both male and female cohorts. DISCUSSION Significant inverse associations between prenatal Cd exposure and birth anthropometry were found in female neonates but not in male neonates, suggesting potential sex differences in the toxico-kinetics and toxico-dynamics of Cd. This research was funded in part by the National Research Foundation (NRF), South Africa (Grant 64528) and the Arctic Monitoring and Assessment Programme (AMAP), ... Article in Journal/Newspaper AMAP Arctic University of Pretoria: UPSpace Arctic PLOS ONE 10 11 e0142455 |
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University of Pretoria: UPSpace |
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ftunivpretoria |
language |
English |
topic |
Prenatal exposure Birth South Africa (SA) Cadmium (Cd) Placental permeability |
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Prenatal exposure Birth South Africa (SA) Cadmium (Cd) Placental permeability Rollin, Halina B. Kootbodien, Tahira Channa, Kalavati Odland, Jon Oyvind Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
topic_facet |
Prenatal exposure Birth South Africa (SA) Cadmium (Cd) Placental permeability |
description |
BACKGROUND The impact of prenatal exposure to cadmium (Cd) on birth outcomes is an area of concern. This study aimed to assess an impact of prenatal Cd exposure on birth outcomes in distinct coastal populations of South Africa. METHODS Cadmium was measured in maternal blood (CdB) (n = 641), cord blood and in maternal urine (n = 317). This investigation assessed the associations between CdB (non-transformed) and birth outcomes across the 25th, 50th, and 75th percentile for birth weight, birth length and head circumference, to test for a linear trend. Associations between natural log-transformed maternal CdB, size at birth and other factors were further evaluated using linear mixed-effects modelling with random intercepts. RESULTS The average gestational age in the total sample was 38 weeks; 47% of neonates were female, average birth weight was 3065 g and 11% were of low birth weight (< 2500 g). The geometric mean (GM) of the maternal CdB level was 0.25 μg/L (n = 641; 95% CI, 0.23– 0.27). The cord blood Cd level was 0.27 μg/L (n = 317; 95% CI, 0.26–0.29) and urine (creatinine- corrected) Cd level was 0.27 μg/L (n = 318; 95% CI, 0.24–0.29). The CdB cord:maternal ratio in the sub-cohort was 1, suggesting that the placenta offers no protective mechanism to the foetus. An inverse association was found between CdB and the lower birth weight percentile in female neonates only (β = - 0.13, p = 0.047). Mothers who reported eating vine vegetables daily had lower levels of CdB (β = - 0.55, p = 0.025). Maternal smoking was associated with an elevation in natural log-transformed CdB levels in both male and female cohorts. DISCUSSION Significant inverse associations between prenatal Cd exposure and birth anthropometry were found in female neonates but not in male neonates, suggesting potential sex differences in the toxico-kinetics and toxico-dynamics of Cd. This research was funded in part by the National Research Foundation (NRF), South Africa (Grant 64528) and the Arctic Monitoring and Assessment Programme (AMAP), ... |
format |
Article in Journal/Newspaper |
author |
Rollin, Halina B. Kootbodien, Tahira Channa, Kalavati Odland, Jon Oyvind |
author_facet |
Rollin, Halina B. Kootbodien, Tahira Channa, Kalavati Odland, Jon Oyvind |
author_sort |
Rollin, Halina B. |
title |
Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
title_short |
Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
title_full |
Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
title_fullStr |
Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
title_full_unstemmed |
Prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of South Africa |
title_sort |
prenatal exposure to cadmium, placental permeability and birth outcomes in coastal populations of south africa |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
http://hdl.handle.net/2263/51764 https://doi.org/10.1371/journal.pone.0142455 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
AMAP Arctic |
genre_facet |
AMAP Arctic |
op_relation |
http://hdl.handle.net/2263/51764 Röllin HB, Kootbodien T, Channa K, Odland JØ (2015) Prenatal Exposure to Cadmium, Placental Permeability and Birth Outcomes in Coastal Populations of South Africa. PLoS ONE 10(11): e0142455. DOI:10.1371/journal.pone.0142455. 1932-6203 doi:10.1371/journal.pone.0142455 |
op_rights |
© 2015 Röllin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0142455 |
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PLOS ONE |
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10 |
container_issue |
11 |
container_start_page |
e0142455 |
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