Role of tau phosphorylation in formation of tau envelopes

• Main Author: Karhanová, Adéla
• Other Authors: Lánský, Zdeněk, Štěpánek, Luděk
• Format: Thesis
• Language: English
• Published: Univerzita Karlova, Přírodovědecká fakulta 2023
• Subjects: tau; tau phosphorylation; tau envelopes; tau islands; tau patches; microtubules; microtubule-associated protein; MAPs; molecular motors; kinesin; severing enzymes; katanin; neurodegeneration; Alzheimer's disease; tau forforylace; tau obálky; tau ostrovy; tau záplaty; mikrotubuly; proteiny asociované s mikrotubuly; molekulární motory; enzymy rozdělující mikrotubuly; neurodegenerace; Alzheimerova choroba; Tau Islands
• Online Access: https://hdl.handle.net/20.500.11956/181446

Tau is an intrinsically-disordered microtubule-associated protein important for axonal development and a critical regulator of microtubule functions in axons. Tau activity is controlled by phosphorylation and its deregulation resulting in tau hyperphosphorylation and aggregation has been linked to m...