Biotransformace monepantelu u rostlin (Campanula rotundifolia, Plantago lanecolata)

• Main Author: Crhová, Anna
• Other Authors: Raisová Stuchlíková, Lucie, Vokřál, Ivan
• Format: Thesis
• Language: Czech
• Published: Univerzita Karlova, Farmaceutická fakulta v Hradci Králové 2018
• Subjects: Biotransformation; monepantel; Campanula rotundifolia; Plantago lanceolata; Biotransformace; Karlova; Harebell
• Online Access: https://hdl.handle.net/20.500.11956/102553

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Anna Crhová Supervisor: RNDr. Lucie Stuchlíková Raisová, Ph.D. Title of diploma thesis: Biotransformation of monepantel in plants (Campanula rotundifolia, Plantago lanceolata) Anthelmintics are veterinary drugs used to eliminate disease caused by parasitic worms. Monepantel (MOP) is a representative of amino-acetonitrile derivatives. This relatively new group of drugs is effective on helminthic strains, which are resistant to classic therapy (benzimidazoles, makrocyklic lactones, imidazothiazoles). Due to high consuption of these drugs, it is important to find out their fate in the exposed organisms. Anthelmintics are in contact with the environment and they can affect terrestrial and aquatic organisms. Their various forms can be accumulate in plants. These plants can be eaten by the animal, which may lead to development of resistance in helminths. In addition, the physiology of plants and animals may be disrupt and, consequently, biodiversity loss may occur. The aim of this study was to determine the biotransformation processes occurring in ribwort plantain (Plantago lanceolata) and harebell (Campanula rotundifolia) after low concentrations of MOP. Suspensions of both plants cells. Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra biochemických věd Kandidát: Bc. Anna Crhová Školitel: RNDr. Lucie Stuchlíková Raisová, Ph.D. Název diplomové práce: Biotransformace monepantelu u rostlin (Campanula rotundifolia, Plantago lanceolata) Anthelmintika jsou veterinární léčiva používaná pro eliminaci nákaz způsobených parazitickými červy. Monepantel (MOP) je zástupcem amino-acetonitrilových derivátů. Tato relativně nová skupina léčiv je účinná i na kmeny helmintů, které jsou rezistentní vůči klasické terapii (benzimidazoly, makrocyklické laktony, imidazothiazoly). Vzhledem k vysoké spotřebě těchto léčiv je potřeba zjistit jejich osud v exponovaných organismech. Anthelmintika se ...