Diversity of bacterial biosynthetic genes in maritime antarctica

• Published in: Microorganisms
• Main Authors: Rego, A., Sousa, A.G.G., Santos, J.P., Pascoal, F., Canário, J., Leão, P.N., Magalhães, C.
• Other Authors: Centro Interdisciplinar de Investigação Marinha e Ambiental
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI 2020
• Subjects: Adenylation (AD); Antarctica; Biosynthetic genes; Computational bioprospection; Ketosynthase (KS); Natural products (NPs); Non-ribosomal peptides (NRPs); Polyketides (PKs); Antarctic; Inach; King George Island; Maxwell Bay; Antarc*
• Online Access: https://hdl.handle.net/10216/130444; https://doi.org/10.3390/microorganisms8020279

Bacterial natural products (NPs) are still a major source of new drug leads. Polyketides (PKs) and non-ribosomal peptides (NRP) are two pharmaceutically important families of NPs and recent studies have revealed Antarctica to harbor endemic polyketide synthase (PKS) and non-ribosomal peptide synthet...