Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane
The esterification reaction of geraniol with acetic acid (100 mM/100 mM) catalyzed by immobilized Candida antarctica lipase B (Novozym 435) was studied in supercritical carbon dioxide (sc-CO2) and in sc-ethane in a packed-bed reactor (PBR). In sc-CO2 it was easy to adjust the water activity (aw) in...
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ftunivporto:oai:repositorio-aberto.up.pt:10216/104723 2023-06-18T03:38:04+02:00 Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane Ricardo Couto Pedro Vidinha Célia Peres Adriano S. Ribeiro Olga Ferreira Manuela V. Oliveira Eugénia A. Macedo José M. Loureiro Susana Barreiros Faculdade de Engenharia 2011 application/pdf https://hdl.handle.net/10216/104723 https://doi.org/10.1021/ie101489j eng eng info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Programa de Financiamento Plurianual de Unidades de I&D/PEst-C/EQB/LA0020/2011/Projeto Estratégico-LA 20 - 2011-2012/LA 20 info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/POCI/EQU/56732/2004/Síntese de acetato de decilo por catálise enzimática em meio supercrítico/POCI/EQU/56732/2004 0888-5885 https://hdl.handle.net/10216/104723 doi:10.1021/ie101489j P-002-V45 info:eu-repo/semantics/restrictedAccess Ciências Tecnológicas Engenharia química Technological sciences Chemical engineering Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering info:eu-repo/semantics/article 2011 ftunivporto https://doi.org/10.1021/ie101489j 2023-06-06T22:20:53Z The esterification reaction of geraniol with acetic acid (100 mM/100 mM) catalyzed by immobilized Candida antarctica lipase B (Novozym 435) was studied in supercritical carbon dioxide (sc-CO2) and in sc-ethane in a packed-bed reactor (PBR). In sc-CO2 it was easy to adjust the water activity (aw) in the reaction mixture to levels leading to good enzyme performance. Enzyme stability was high and steady-state conversions could be achieved that exceeded the largest conversions measured in batch stirred-tank reactors (BSTRs), which is probably due to the lower aw levels achieved in the PBR. In sc-ethane, where the solubility of water is lower, high steady-state conversions could be attained only by preventing the accumulation on the enzyme bed of the water produced during reaction. The kinetic parameters for the reaction in sc-CO2 were determined using previously published data obtained in a BSTR, and a model was developed for the PBR that included those kinetic parameters. This model was able to predict with reasonable accuracy the behavior of the PBR. Slight differences were observed for some operating regions, probably due to the influence of aw in the activity of the enzyme, which is not included in the model. Article in Journal/Newspaper Antarc* Antarctica Repositório Aberto da Universidade do Porto Industrial & Engineering Chemistry Research 50 4 1938 1946 |
institution |
Open Polar |
collection |
Repositório Aberto da Universidade do Porto |
op_collection_id |
ftunivporto |
language |
English |
topic |
Ciências Tecnológicas Engenharia química Technological sciences Chemical engineering Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering |
spellingShingle |
Ciências Tecnológicas Engenharia química Technological sciences Chemical engineering Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering Ricardo Couto Pedro Vidinha Célia Peres Adriano S. Ribeiro Olga Ferreira Manuela V. Oliveira Eugénia A. Macedo José M. Loureiro Susana Barreiros Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
topic_facet |
Ciências Tecnológicas Engenharia química Technological sciences Chemical engineering Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering |
description |
The esterification reaction of geraniol with acetic acid (100 mM/100 mM) catalyzed by immobilized Candida antarctica lipase B (Novozym 435) was studied in supercritical carbon dioxide (sc-CO2) and in sc-ethane in a packed-bed reactor (PBR). In sc-CO2 it was easy to adjust the water activity (aw) in the reaction mixture to levels leading to good enzyme performance. Enzyme stability was high and steady-state conversions could be achieved that exceeded the largest conversions measured in batch stirred-tank reactors (BSTRs), which is probably due to the lower aw levels achieved in the PBR. In sc-ethane, where the solubility of water is lower, high steady-state conversions could be attained only by preventing the accumulation on the enzyme bed of the water produced during reaction. The kinetic parameters for the reaction in sc-CO2 were determined using previously published data obtained in a BSTR, and a model was developed for the PBR that included those kinetic parameters. This model was able to predict with reasonable accuracy the behavior of the PBR. Slight differences were observed for some operating regions, probably due to the influence of aw in the activity of the enzyme, which is not included in the model. |
author2 |
Faculdade de Engenharia |
format |
Article in Journal/Newspaper |
author |
Ricardo Couto Pedro Vidinha Célia Peres Adriano S. Ribeiro Olga Ferreira Manuela V. Oliveira Eugénia A. Macedo José M. Loureiro Susana Barreiros |
author_facet |
Ricardo Couto Pedro Vidinha Célia Peres Adriano S. Ribeiro Olga Ferreira Manuela V. Oliveira Eugénia A. Macedo José M. Loureiro Susana Barreiros |
author_sort |
Ricardo Couto |
title |
Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
title_short |
Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
title_full |
Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
title_fullStr |
Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
title_full_unstemmed |
Geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
title_sort |
geranyl acetate synthesis in a packed-bed reactor catalyzed by novozym in supercritical carbon dioxide and in supercritical ethane |
publishDate |
2011 |
url |
https://hdl.handle.net/10216/104723 https://doi.org/10.1021/ie101489j |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Programa de Financiamento Plurianual de Unidades de I&D/PEst-C/EQB/LA0020/2011/Projeto Estratégico-LA 20 - 2011-2012/LA 20 info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/POCI/EQU/56732/2004/Síntese de acetato de decilo por catálise enzimática em meio supercrítico/POCI/EQU/56732/2004 0888-5885 https://hdl.handle.net/10216/104723 doi:10.1021/ie101489j P-002-V45 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1021/ie101489j |
container_title |
Industrial & Engineering Chemistry Research |
container_volume |
50 |
container_issue |
4 |
container_start_page |
1938 |
op_container_end_page |
1946 |
_version_ |
1769010878305271808 |