Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from...
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Online Access: | http://hdl.handle.net/11568/118878 https://doi.org/10.1371/journal.pgen.1000209 |
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ftunivpisairis:oai:arpi.unipi.it:11568/118878 2024-04-21T07:47:04+00:00 Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic MILLAR C. D DODD A ANDERSON J GIBB G. C RITCHIE P. A WOODHAMS M. D HENDY M. D LAMBERT D. M. BARONI, CARLO Millar, C. D. Dodd, A Anderson, J Gibb, G. C. Ritchie, P. A. Baroni, Carlo Woodhams, M. D. Hendy, M. D. Lambert, D. M. 2008 STAMPA http://hdl.handle.net/11568/118878 https://doi.org/10.1371/journal.pgen.1000209 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000261480900005 volume:4 issue:10 firstpage:1 lastpage:9 numberofpages:9 journal:PLOS GENETICS http://hdl.handle.net/11568/118878 doi:10.1371/journal.pgen.1000209 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-55249118852 mitochondrial-dna substitution rate molecular clock time dependency control region ancient DNA segregation Adélie Penguin Pygoscelis adeliae Antarctica Relict penguin colonies info:eu-repo/semantics/article 2008 ftunivpisairis https://doi.org/10.1371/journal.pgen.1000209 2024-03-28T01:25:15Z Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates measured over longer time periods. To resolve this apparent contradiction, we have examined the hypervariable region (HVR I) of the mitochondrial genome using families of Ade ́ lie penguins (Pygoscelis adeliae) from the Antarctic. We sequenced 344 bps of the HVR I from penguins comprising 508 families with 915 chicks, together with both their parents. All of the 62 germline heteroplasmies that we detected in mothers were also detected in their offspring, consistent with maternal inheritance. These data give an estimated mutation rate (m) of 0.55 mutations/site/Myrs (HPD 95% confidence interval of 0.29–0.88 mutations/site/Myrs) after accounting for the persistence of these heteroplasmies and the sensitivity of current detection methods. In comparison, the rate of evolution (k) of the same HVR I region, determined using DNA sequences from 162 known age sub-fossil bones spanning a 37,000-year period, was 0.86 substitutions/site/Myrs (HPD 95% confidence interval of 0.53 and 1.17). Importantly, the latter rate is not statistically different from our estimate of the mutation rate. These results are in contrast to the view that molecular rates are time dependent. Article in Journal/Newspaper Antarc* Antarctic Antarctica Pygoscelis adeliae ARPI - Archivio della Ricerca dell'Università di Pisa PLoS Genetics 4 10 e1000209 |
institution |
Open Polar |
collection |
ARPI - Archivio della Ricerca dell'Università di Pisa |
op_collection_id |
ftunivpisairis |
language |
English |
topic |
mitochondrial-dna substitution rate molecular clock time dependency control region ancient DNA segregation Adélie Penguin Pygoscelis adeliae Antarctica Relict penguin colonies |
spellingShingle |
mitochondrial-dna substitution rate molecular clock time dependency control region ancient DNA segregation Adélie Penguin Pygoscelis adeliae Antarctica Relict penguin colonies MILLAR C. D DODD A ANDERSON J GIBB G. C RITCHIE P. A WOODHAMS M. D HENDY M. D LAMBERT D. M. BARONI, CARLO Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
topic_facet |
mitochondrial-dna substitution rate molecular clock time dependency control region ancient DNA segregation Adélie Penguin Pygoscelis adeliae Antarctica Relict penguin colonies |
description |
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates measured over longer time periods. To resolve this apparent contradiction, we have examined the hypervariable region (HVR I) of the mitochondrial genome using families of Ade ́ lie penguins (Pygoscelis adeliae) from the Antarctic. We sequenced 344 bps of the HVR I from penguins comprising 508 families with 915 chicks, together with both their parents. All of the 62 germline heteroplasmies that we detected in mothers were also detected in their offspring, consistent with maternal inheritance. These data give an estimated mutation rate (m) of 0.55 mutations/site/Myrs (HPD 95% confidence interval of 0.29–0.88 mutations/site/Myrs) after accounting for the persistence of these heteroplasmies and the sensitivity of current detection methods. In comparison, the rate of evolution (k) of the same HVR I region, determined using DNA sequences from 162 known age sub-fossil bones spanning a 37,000-year period, was 0.86 substitutions/site/Myrs (HPD 95% confidence interval of 0.53 and 1.17). Importantly, the latter rate is not statistically different from our estimate of the mutation rate. These results are in contrast to the view that molecular rates are time dependent. |
author2 |
Millar, C. D. Dodd, A Anderson, J Gibb, G. C. Ritchie, P. A. Baroni, Carlo Woodhams, M. D. Hendy, M. D. Lambert, D. M. |
format |
Article in Journal/Newspaper |
author |
MILLAR C. D DODD A ANDERSON J GIBB G. C RITCHIE P. A WOODHAMS M. D HENDY M. D LAMBERT D. M. BARONI, CARLO |
author_facet |
MILLAR C. D DODD A ANDERSON J GIBB G. C RITCHIE P. A WOODHAMS M. D HENDY M. D LAMBERT D. M. BARONI, CARLO |
author_sort |
MILLAR C. D |
title |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_short |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_full |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_fullStr |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_full_unstemmed |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_sort |
mutation and evolutionary rates in adélie penguins from the antarctic |
publishDate |
2008 |
url |
http://hdl.handle.net/11568/118878 https://doi.org/10.1371/journal.pgen.1000209 |
genre |
Antarc* Antarctic Antarctica Pygoscelis adeliae |
genre_facet |
Antarc* Antarctic Antarctica Pygoscelis adeliae |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000261480900005 volume:4 issue:10 firstpage:1 lastpage:9 numberofpages:9 journal:PLOS GENETICS http://hdl.handle.net/11568/118878 doi:10.1371/journal.pgen.1000209 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-55249118852 |
op_doi |
https://doi.org/10.1371/journal.pgen.1000209 |
container_title |
PLoS Genetics |
container_volume |
4 |
container_issue |
10 |
container_start_page |
e1000209 |
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1796945309931143168 |