Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach

One of the main aspect of this thesis is to produce and offer to the scientific community mechanistic details on the interaction between small molecules and biosubstrates for complex selected systems of high biomedical interest. For every system, we highlight and discuss the critical aspects for cor...

Full description

Bibliographic Details
Main Author: MACII, FRANCESCA
Other Authors: Biver, Tarita
Format: Text
Language:Italian
Published: Pisa University 2021
Subjects:
Online Access:http://etd.adm.unipi.it/theses/available/etd-02072021-105023/
id ftunivpisa:oai:etd.adm.unipi.it:etd-02072021-105023
record_format openpolar
spelling ftunivpisa:oai:etd.adm.unipi.it:etd-02072021-105023 2023-05-15T13:33:02+02:00 Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach MACII, FRANCESCA Biver, Tarita 2021-02-09 application/pdf http://etd.adm.unipi.it/theses/available/etd-02072021-105023/ it ita Pisa University http://etd.adm.unipi.it/theses/available/etd-02072021-105023/ info:eu-repo/semantics/embargoedAccess Copyright information available at source archive http://etd.adm.unipi.it/theses/available/etd-02072021-105023/ CHIM/01 text 2021 ftunivpisa 2022-12-26T14:13:47Z One of the main aspect of this thesis is to produce and offer to the scientific community mechanistic details on the interaction between small molecules and biosubstrates for complex selected systems of high biomedical interest. For every system, we highlight and discuss the critical aspects for correctly designing the experiments and treating the data. The binding of small molecules to biosubstrates deserves interest from two apparently opposite point of views. On one side, the development of new efficient anticancer agents. On the other hand, the analysis of the effects of possible tumour-genic species. For the first aspect, although the many studies involved, there are still many unsolved problems mainly related to drug resistance and detrimental effects on the patients. Concerning the second aspect, and in the context of our participation to National Antarctic Research Program (PNRA), our attention has been focused on Persistent Organic Pollutants (POPs), which were demonstrated to enhance tumour morbidity. On the whole, we provided detailed discussions on the binding modes of the selected systems, by employing a combination of experimental and computational techniques. Text Antarc* Antarctic National Antarctic Research Program Università di Pisa: ETD (Electronic Theses and Dissertations) Antarctic
institution Open Polar
collection Università di Pisa: ETD (Electronic Theses and Dissertations)
op_collection_id ftunivpisa
language Italian
topic CHIM/01
spellingShingle CHIM/01
MACII, FRANCESCA
Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
topic_facet CHIM/01
description One of the main aspect of this thesis is to produce and offer to the scientific community mechanistic details on the interaction between small molecules and biosubstrates for complex selected systems of high biomedical interest. For every system, we highlight and discuss the critical aspects for correctly designing the experiments and treating the data. The binding of small molecules to biosubstrates deserves interest from two apparently opposite point of views. On one side, the development of new efficient anticancer agents. On the other hand, the analysis of the effects of possible tumour-genic species. For the first aspect, although the many studies involved, there are still many unsolved problems mainly related to drug resistance and detrimental effects on the patients. Concerning the second aspect, and in the context of our participation to National Antarctic Research Program (PNRA), our attention has been focused on Persistent Organic Pollutants (POPs), which were demonstrated to enhance tumour morbidity. On the whole, we provided detailed discussions on the binding modes of the selected systems, by employing a combination of experimental and computational techniques.
author2 Biver, Tarita
format Text
author MACII, FRANCESCA
author_facet MACII, FRANCESCA
author_sort MACII, FRANCESCA
title Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
title_short Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
title_full Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
title_fullStr Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
title_full_unstemmed Mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
title_sort mechanistic studies on the interaction between small molecules and biosubstrates: a multitechnique approach
publisher Pisa University
publishDate 2021
url http://etd.adm.unipi.it/theses/available/etd-02072021-105023/
geographic Antarctic
geographic_facet Antarctic
genre Antarc*
Antarctic
National Antarctic Research Program
genre_facet Antarc*
Antarctic
National Antarctic Research Program
op_source http://etd.adm.unipi.it/theses/available/etd-02072021-105023/
op_relation http://etd.adm.unipi.it/theses/available/etd-02072021-105023/
op_rights info:eu-repo/semantics/embargoedAccess
Copyright information available at source archive
_version_ 1766037921546108928