Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

• Published in: Developmental & Comparative Immunology
• Main Authors: Lafont, Maxime, Goncalves, Priscila, Guo, Ximing, Montagnani, Caroline, Raftos, David, Green, Timothy
• Other Authors: Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Sydney Institute of Marine Science, Macquarie University Sydney, Haskin Shellfish Research Laboratory (HSRL), Rutgers, The State University of New Jersey New Brunswick (RU), Rutgers University System (Rutgers)-Rutgers University System (Rutgers)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2019
• Subjects: Crassostrea gigas; OsHV-1; Transgenerational immune priming; Trained immunity; RNA-seq; [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity; [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology; [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology; Pacific; Pacific oyster
• Online Access: https://hal.science/hal-01904719; https://hal.science/hal-01904719/document; https://hal.science/hal-01904719/file/Lafont-2019-DevComIm-Transgenerational-MANUSCRIT.pdf; https://doi.org/10.1016/j.dci.2018.09.022

International audience The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure to poly(I:C) has been found in later life stages (within-generational immune priming) and in the next generation (transgenerational immune priming). The mechanism that the oyster uses to transfer immunity to the next generation is unknown. Here we show that oyster larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. We conclude that the improved survival of larvae might occur via maternal provisioning of antiviral compounds in the eggs.