A signal, from human mtDNA, of postglacial recolonization in Europe
Mitochondrial HVS-I sequences from 10,365 subjects belonging to 56 populations/geographical regions of western Eurasia and northern Africa were first surveyed for the presence of the T-->C transition at nucleotide position 16298, a mutation which has previously been shown to characterize haplogro...
Published in: | The American Journal of Human Genetics |
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Online Access: | http://hdl.handle.net/11571/8613 https://doi.org/10.1086/323485 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226069/?tool=pubmed |
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ftunivpavia:oai:iris.unipv.it:11571/8613 2024-04-14T08:18:49+00:00 A signal, from human mtDNA, of postglacial recolonization in Europe TORRONI, ANTONIO RENGO, CHIARA AL-ZAHERY, NADIA BENERECETTI, AUGUSTA SILVANA SEMINO, ORNELLA BANDELT HJ MACAULAY V RICHARDS M CRUCIANI F MARTINEZ CABRERA V VILLEMS R KIVISILD T METSPALU E PARIK J TOLK HV TAMBETS K FORSTER P KARGER B FRANCALACCI P RUDAN P JANICIJEVIC B RICKARDS O SAVONTAUS ML HUOPONEN K LAITINEN V KOIVUMÄKI S SYKES B HICKEY E NOVELLETTO A MORAL P SELLITTO D COPPA A SCOZZARI R. Torroni, Antonio Bandelt, Hj Macaulay, V Richards, M Cruciani, F Rengo, Chiara MARTINEZ CABRERA, V Villems, R Kivisild, T Metspalu, E Parik, J Tolk, Hv Tambets, K Forster, P Karger, B Francalacci, P Rudan, P Janicijevic, B Rickards, O Savontaus, Ml Huoponen, K Laitinen, V Koivumäki, S Sykes, B Hickey, E Novelletto, A Moral, P Sellitto, D Coppa, A AL-ZAHERY, Nadia Benerecetti, AUGUSTA SILVANA Semino, Ornella Scozzari, R. 2001 STAMPA http://hdl.handle.net/11571/8613 https://doi.org/10.1086/323485 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226069/?tool=pubmed eng eng info:eu-repo/semantics/altIdentifier/pmid/11517423 info:eu-repo/semantics/altIdentifier/wos/000171008200016 volume:69 issue:4 firstpage:844 lastpage:852 numberofpages:9 journal:AMERICAN JOURNAL OF HUMAN GENETICS http://hdl.handle.net/11571/8613 doi:10.1086/323485 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0034822098 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226069/?tool=pubmed HUMAN MITOCHONDRIAL DNA HAPLOGROUP V ORIGIN OF EUROPEANS LAST GLACIAL MAXIMUM FRANCO-CANTABRIAN REFUGE info:eu-repo/semantics/article 2001 ftunivpavia https://doi.org/10.1086/323485 2024-03-21T16:00:17Z Mitochondrial HVS-I sequences from 10,365 subjects belonging to 56 populations/geographical regions of western Eurasia and northern Africa were first surveyed for the presence of the T-->C transition at nucleotide position 16298, a mutation which has previously been shown to characterize haplogroup V mtDNAs. All mtDNAs with this mutation were then screened for a number of diagnostic RFLP sites, revealing two major subsets of mtDNAs. One is haplogroup V proper, and the other has been termed "pre*V," since it predates V phylogenetically. The rather uncommon pre*V tends to be scattered throughout Europe (and northwestern Africa), whereas V attains two peaks of frequency: one situated in southwestern Europe and one in the Saami of northern Scandinavia. Geographical distributions and ages support the scenario that pre*V originated in Europe before the Last Glacial Maximum (LGM), whereas the more recently derived haplogroup V arose in a southwestern European refugium soon after the LGM. The arrival of V in eastern/central Europe, however, occurred much later, possibly with (post-)Neolithic contacts. The distribution of haplogroup V mtDNAs in modern European populations would thus, at least in part, reflect the pattern of postglacial human recolonization from that refugium, affecting even the Saami. Overall, the present study shows that the dissection of mtDNA variation into small and well-defined evolutionary units is an essential step in the identification of spatial frequency patterns. Mass screening of a few markers identified using complete mtDNA sequences promises to be an efficient strategy for inferring features of human prehistory. Article in Journal/Newspaper saami IRIS UNIPV (Università degli studi di Pavia) The American Journal of Human Genetics 69 4 844 852 |
institution |
Open Polar |
collection |
IRIS UNIPV (Università degli studi di Pavia) |
op_collection_id |
ftunivpavia |
language |
English |
topic |
HUMAN MITOCHONDRIAL DNA HAPLOGROUP V ORIGIN OF EUROPEANS LAST GLACIAL MAXIMUM FRANCO-CANTABRIAN REFUGE |
spellingShingle |
HUMAN MITOCHONDRIAL DNA HAPLOGROUP V ORIGIN OF EUROPEANS LAST GLACIAL MAXIMUM FRANCO-CANTABRIAN REFUGE TORRONI, ANTONIO RENGO, CHIARA AL-ZAHERY, NADIA BENERECETTI, AUGUSTA SILVANA SEMINO, ORNELLA BANDELT HJ MACAULAY V RICHARDS M CRUCIANI F MARTINEZ CABRERA V VILLEMS R KIVISILD T METSPALU E PARIK J TOLK HV TAMBETS K FORSTER P KARGER B FRANCALACCI P RUDAN P JANICIJEVIC B RICKARDS O SAVONTAUS ML HUOPONEN K LAITINEN V KOIVUMÄKI S SYKES B HICKEY E NOVELLETTO A MORAL P SELLITTO D COPPA A SCOZZARI R. A signal, from human mtDNA, of postglacial recolonization in Europe |
topic_facet |
HUMAN MITOCHONDRIAL DNA HAPLOGROUP V ORIGIN OF EUROPEANS LAST GLACIAL MAXIMUM FRANCO-CANTABRIAN REFUGE |
description |
Mitochondrial HVS-I sequences from 10,365 subjects belonging to 56 populations/geographical regions of western Eurasia and northern Africa were first surveyed for the presence of the T-->C transition at nucleotide position 16298, a mutation which has previously been shown to characterize haplogroup V mtDNAs. All mtDNAs with this mutation were then screened for a number of diagnostic RFLP sites, revealing two major subsets of mtDNAs. One is haplogroup V proper, and the other has been termed "pre*V," since it predates V phylogenetically. The rather uncommon pre*V tends to be scattered throughout Europe (and northwestern Africa), whereas V attains two peaks of frequency: one situated in southwestern Europe and one in the Saami of northern Scandinavia. Geographical distributions and ages support the scenario that pre*V originated in Europe before the Last Glacial Maximum (LGM), whereas the more recently derived haplogroup V arose in a southwestern European refugium soon after the LGM. The arrival of V in eastern/central Europe, however, occurred much later, possibly with (post-)Neolithic contacts. The distribution of haplogroup V mtDNAs in modern European populations would thus, at least in part, reflect the pattern of postglacial human recolonization from that refugium, affecting even the Saami. Overall, the present study shows that the dissection of mtDNA variation into small and well-defined evolutionary units is an essential step in the identification of spatial frequency patterns. Mass screening of a few markers identified using complete mtDNA sequences promises to be an efficient strategy for inferring features of human prehistory. |
author2 |
Torroni, Antonio Bandelt, Hj Macaulay, V Richards, M Cruciani, F Rengo, Chiara MARTINEZ CABRERA, V Villems, R Kivisild, T Metspalu, E Parik, J Tolk, Hv Tambets, K Forster, P Karger, B Francalacci, P Rudan, P Janicijevic, B Rickards, O Savontaus, Ml Huoponen, K Laitinen, V Koivumäki, S Sykes, B Hickey, E Novelletto, A Moral, P Sellitto, D Coppa, A AL-ZAHERY, Nadia Benerecetti, AUGUSTA SILVANA Semino, Ornella Scozzari, R. |
format |
Article in Journal/Newspaper |
author |
TORRONI, ANTONIO RENGO, CHIARA AL-ZAHERY, NADIA BENERECETTI, AUGUSTA SILVANA SEMINO, ORNELLA BANDELT HJ MACAULAY V RICHARDS M CRUCIANI F MARTINEZ CABRERA V VILLEMS R KIVISILD T METSPALU E PARIK J TOLK HV TAMBETS K FORSTER P KARGER B FRANCALACCI P RUDAN P JANICIJEVIC B RICKARDS O SAVONTAUS ML HUOPONEN K LAITINEN V KOIVUMÄKI S SYKES B HICKEY E NOVELLETTO A MORAL P SELLITTO D COPPA A SCOZZARI R. |
author_facet |
TORRONI, ANTONIO RENGO, CHIARA AL-ZAHERY, NADIA BENERECETTI, AUGUSTA SILVANA SEMINO, ORNELLA BANDELT HJ MACAULAY V RICHARDS M CRUCIANI F MARTINEZ CABRERA V VILLEMS R KIVISILD T METSPALU E PARIK J TOLK HV TAMBETS K FORSTER P KARGER B FRANCALACCI P RUDAN P JANICIJEVIC B RICKARDS O SAVONTAUS ML HUOPONEN K LAITINEN V KOIVUMÄKI S SYKES B HICKEY E NOVELLETTO A MORAL P SELLITTO D COPPA A SCOZZARI R. |
author_sort |
TORRONI, ANTONIO |
title |
A signal, from human mtDNA, of postglacial recolonization in Europe |
title_short |
A signal, from human mtDNA, of postglacial recolonization in Europe |
title_full |
A signal, from human mtDNA, of postglacial recolonization in Europe |
title_fullStr |
A signal, from human mtDNA, of postglacial recolonization in Europe |
title_full_unstemmed |
A signal, from human mtDNA, of postglacial recolonization in Europe |
title_sort |
signal, from human mtdna, of postglacial recolonization in europe |
publishDate |
2001 |
url |
http://hdl.handle.net/11571/8613 https://doi.org/10.1086/323485 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226069/?tool=pubmed |
genre |
saami |
genre_facet |
saami |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/11517423 info:eu-repo/semantics/altIdentifier/wos/000171008200016 volume:69 issue:4 firstpage:844 lastpage:852 numberofpages:9 journal:AMERICAN JOURNAL OF HUMAN GENETICS http://hdl.handle.net/11571/8613 doi:10.1086/323485 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0034822098 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226069/?tool=pubmed |
op_doi |
https://doi.org/10.1086/323485 |
container_title |
The American Journal of Human Genetics |
container_volume |
69 |
container_issue |
4 |
container_start_page |
844 |
op_container_end_page |
852 |
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1796318364437577728 |