Bioctive glycoglycerolipid analogues: an expeditious enzymatic approach to mono- and diesters of 2-O-beta-D-galactoglycerol

• Published in: Tetrahedron: Asymmetry
• Main Authors: D. Colombo, F. Ronchetti, A. Scala, TOMA, LUCIO
• Other Authors: D., Colombo, F., Ronchetti, A., Scala, Toma, Lucio
• Format: Article in Journal/Newspaper
• Language: English
• Published: 1998
• Subjects: Antarc*; Antarctica
• Online Access: http://hdl.handle.net/11571/455825; https://doi.org/10.1016/S0957-4166(98)00207-9

2-O-beta-D-Galactosylglycerol 1 was submitted to acylation using Pseudomonas cepacia or Candida antarctica lipases as catalysts and 2,2,2-trifluoroethyl esters of butanoic, hexanoic, octanoic or decanoic acid as acyl carriers. Taking advantage of the high diastereoselectivity and regioselectivity of the two enzymes, the 1-O-, 3-O-, 6'-O-acyl and the 1,6'-di-O-acylderivatives of 1 were obtained pure or in an appreciably enriched form. (C) 1998 Elsevier Science Ltd. All rights reserved.