Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups
In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and...
Published in: | Annals of Human Genetics |
---|---|
Main Authors: | , , , , , , , , , , |
Other Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2005
|
Subjects: | |
Online Access: | http://hdl.handle.net/11571/134511 https://doi.org/10.1046/j.1529-8817.2003.00127.x http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8817.2003.00127.x/abstract |
id |
ftunivpavia:oai:iris.unipv.it:11571/134511 |
---|---|
record_format |
openpolar |
spelling |
ftunivpavia:oai:iris.unipv.it:11571/134511 2024-04-14T08:07:41+00:00 Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups STARIKOVSKAYA EB SUKERNIK RI DERBENEVA OA VOLODKO NV RUIZ PESINI E BROWN MD LOTT MT HOSSEINI SH HUOPONEN K WALLACE DC TORRONI, ANTONIO Starikovskaya, Eb Sukernik, Ri Derbeneva, Oa Volodko, Nv RUIZ PESINI, E Torroni, Antonio Brown, Md Lott, Mt Hosseini, Sh Huoponen, K Wallace, Dc 2005 STAMPA http://hdl.handle.net/11571/134511 https://doi.org/10.1046/j.1529-8817.2003.00127.x http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8817.2003.00127.x/abstract eng eng info:eu-repo/semantics/altIdentifier/pmid/15638829 info:eu-repo/semantics/altIdentifier/wos/000226627700008 volume:69 issue:1 firstpage:67 lastpage:89 numberofpages:23 journal:ANNALS OF HUMAN GENETICS http://hdl.handle.net/11571/134511 doi:10.1046/j.1529-8817.2003.00127.x info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-20844441597 http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8817.2003.00127.x/abstract ORIGIN OF NATIVE AMERICANS SIBERIAN POPULATIONS MITOCHONDRIAL DNA HAPLOGROUPS PHYLOGEOGRAPHY info:eu-repo/semantics/article 2005 ftunivpavia https://doi.org/10.1046/j.1529-8817.2003.00127.x 2024-03-21T15:53:54Z In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and surveyed for additional polymorphic markers in the coding region. Furthermore, the mtDNAs selected according to haplogroup/subhaplogroup status were completely sequenced. Phylogenetic analyses of the resulting data, combined with those from previously published Siberian arctic and sub-arctic populations, revealed that remnants of the ancient Siberian gene pool are still evident in Siberian populations, suggesting that the founding haplotypes of the Native American A-D branches originated in different parts of Siberia. Thus, lineage A complete sequences revealed in the Mansi of the Lower Ob and the Ket of the Lower Yenisei belong to A1, suggesting that A1 mtDNAs occasionally found in the remnants of hunting-gathering populations of northwestern and northern Siberia belonged to a common gene pool of the Siberian progenitors of Paleoindians. Moreover, lineage B1, which is the most closely related to the American B2, occurred in the Tubalar and Tuvan inhabiting the territory between the upper reaches of the Ob River in the west, to the Upper Yenisei region in the east. Finally, the sequence variants of haplogroups C and D, which are most similar to Native American C1 and D1, were detected in the Ulchi of the Lower Amur. Overall, our data suggest that the immediate ancestors of the Siberian/Beringian migrants who gave rise to ancient (pre-Clovis) Paleoindians have a common origin with aboriginal people of the area now designated the Altai-Sayan Upland, as well as the Lower Amur/Sea of Okhotsk region. Article in Journal/Newspaper Arctic ob river Mansi Siberia IRIS UNIPV (Università degli studi di Pavia) Arctic Okhotsk Annals of Human Genetics 69 1 67 89 |
institution |
Open Polar |
collection |
IRIS UNIPV (Università degli studi di Pavia) |
op_collection_id |
ftunivpavia |
language |
English |
topic |
ORIGIN OF NATIVE AMERICANS SIBERIAN POPULATIONS MITOCHONDRIAL DNA HAPLOGROUPS PHYLOGEOGRAPHY |
spellingShingle |
ORIGIN OF NATIVE AMERICANS SIBERIAN POPULATIONS MITOCHONDRIAL DNA HAPLOGROUPS PHYLOGEOGRAPHY STARIKOVSKAYA EB SUKERNIK RI DERBENEVA OA VOLODKO NV RUIZ PESINI E BROWN MD LOTT MT HOSSEINI SH HUOPONEN K WALLACE DC TORRONI, ANTONIO Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
topic_facet |
ORIGIN OF NATIVE AMERICANS SIBERIAN POPULATIONS MITOCHONDRIAL DNA HAPLOGROUPS PHYLOGEOGRAPHY |
description |
In search of the ancestors of Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed the mtDNA of 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high-resolution RFLP analysis, sequencing of the control-region hypervariable segment I (HVS-I), and surveyed for additional polymorphic markers in the coding region. Furthermore, the mtDNAs selected according to haplogroup/subhaplogroup status were completely sequenced. Phylogenetic analyses of the resulting data, combined with those from previously published Siberian arctic and sub-arctic populations, revealed that remnants of the ancient Siberian gene pool are still evident in Siberian populations, suggesting that the founding haplotypes of the Native American A-D branches originated in different parts of Siberia. Thus, lineage A complete sequences revealed in the Mansi of the Lower Ob and the Ket of the Lower Yenisei belong to A1, suggesting that A1 mtDNAs occasionally found in the remnants of hunting-gathering populations of northwestern and northern Siberia belonged to a common gene pool of the Siberian progenitors of Paleoindians. Moreover, lineage B1, which is the most closely related to the American B2, occurred in the Tubalar and Tuvan inhabiting the territory between the upper reaches of the Ob River in the west, to the Upper Yenisei region in the east. Finally, the sequence variants of haplogroups C and D, which are most similar to Native American C1 and D1, were detected in the Ulchi of the Lower Amur. Overall, our data suggest that the immediate ancestors of the Siberian/Beringian migrants who gave rise to ancient (pre-Clovis) Paleoindians have a common origin with aboriginal people of the area now designated the Altai-Sayan Upland, as well as the Lower Amur/Sea of Okhotsk region. |
author2 |
Starikovskaya, Eb Sukernik, Ri Derbeneva, Oa Volodko, Nv RUIZ PESINI, E Torroni, Antonio Brown, Md Lott, Mt Hosseini, Sh Huoponen, K Wallace, Dc |
format |
Article in Journal/Newspaper |
author |
STARIKOVSKAYA EB SUKERNIK RI DERBENEVA OA VOLODKO NV RUIZ PESINI E BROWN MD LOTT MT HOSSEINI SH HUOPONEN K WALLACE DC TORRONI, ANTONIO |
author_facet |
STARIKOVSKAYA EB SUKERNIK RI DERBENEVA OA VOLODKO NV RUIZ PESINI E BROWN MD LOTT MT HOSSEINI SH HUOPONEN K WALLACE DC TORRONI, ANTONIO |
author_sort |
STARIKOVSKAYA EB |
title |
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
title_short |
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
title_full |
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
title_fullStr |
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
title_full_unstemmed |
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origin of Native American haplogroups |
title_sort |
mitochondrial dna diversity in indigenous populations of the southern extent of siberia, and the origin of native american haplogroups |
publishDate |
2005 |
url |
http://hdl.handle.net/11571/134511 https://doi.org/10.1046/j.1529-8817.2003.00127.x http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8817.2003.00127.x/abstract |
geographic |
Arctic Okhotsk |
geographic_facet |
Arctic Okhotsk |
genre |
Arctic ob river Mansi Siberia |
genre_facet |
Arctic ob river Mansi Siberia |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/15638829 info:eu-repo/semantics/altIdentifier/wos/000226627700008 volume:69 issue:1 firstpage:67 lastpage:89 numberofpages:23 journal:ANNALS OF HUMAN GENETICS http://hdl.handle.net/11571/134511 doi:10.1046/j.1529-8817.2003.00127.x info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-20844441597 http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8817.2003.00127.x/abstract |
op_doi |
https://doi.org/10.1046/j.1529-8817.2003.00127.x |
container_title |
Annals of Human Genetics |
container_volume |
69 |
container_issue |
1 |
container_start_page |
67 |
op_container_end_page |
89 |
_version_ |
1796305101802962944 |