Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: Findings from two prospective cohorts

• Published in: Scientific Reports
• Main Authors: Fleming, T., Tu, Y.-K., Lundh, T., Chien, W.J., Lee, W.-C., Hsiao, C.K., Kuo, P.-H., Hung, H., Liao, S.-F., Berger, Eric, Delpierre, C., Hosnijeh, F.S., Kelly-Irving, M., Portengen, L., Bergdahl, I.A., Johansson, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Kyrtopoulos, S.A., Vineis, P., Chadeau-Hyam, R., Castagné, R., Melin, B., Lenner, P., Bendinelli, B., Botsivali, M., Chatziioannou, A., Valavanis, B., Garrido-Manriquez, J., Athersuch, T.J., Liquet, Benoit, Lokhorst, H., Georgiadis, P., Kleinjans, T.M.C.M., Keun, H.C., Kelly, R., Hallmans, E.G., Myridakis, A., Kogevinas, M., Fazzo, M., Comba, P., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M., Fleming, S.
• Other Authors: Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention, Unit of Cancer Epidemiology, AOU S. Giovanni Battista, CPO Piemonte, Università degli studi di Torino = University of Turin (UNITO), Civile - M.P.Arezzo Hospital, Department of Epidemiology and Public Health, Imperial College London, Department of Radiation Sciences, Oncology, Umeå University, Laboratoire de Mathématiques et de leurs Applications Pau (LMAP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Centre for Environment and Life Sciences, Commonwealth Scientific and Industrial Research Organisation Canberra (CSIRO), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra Barcelona (UPF)-Catalunya ministerio de salud
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2018
• Subjects: [MATH]Mathematics [math]; Northern Sweden
• Online Access: https://hal.science/hal-02134590; https://doi.org/10.1038/s41598-018-29041-1

ACL International audience Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and.-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (beta = -1.28, p = 0.012), and, to lesser, extent with BC (beta = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.