Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France)
The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminan...
Published in: | Environmental Pollution |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Elsevier
2022
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Online Access: | http://hdl.handle.net/10810/58538 https://doi.org/10.1016/j.envpol.2022.120016 |
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ftunivpaisvasco:oai:addi.ehu.eus:10810/58538 2023-05-15T13:27:30+02:00 Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) Álvarez Mora, Iker Bolliet, Valérie López Herguedas, Naroa Castro, Lyen Anakabe Iturriaga, Eneritz Monperrus, Mathilde Elisabeth Etxebarria Loizate, Nestor 2022-10 application/pdf http://hdl.handle.net/10810/58538 https://doi.org/10.1016/j.envpol.2022.120016 eng eng Elsevier info:eu-repo/grantAgreement/MINECO/CTM2017-84763-C3-1-R https://www.sciencedirect.com/science/article/pii/S0269749122012301?via%3Dihub Environmental Pollution 311 : (2022) // Article ID 120016 0269-7491 1873-6424 http://hdl.handle.net/10810/58538 doi:10.1016/j.envpol.2022.120016 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/3.0/es/ /© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by- nc/4.0/) Atribución-NoComercial 3.0 España CC-BY-NC glass eel contaminants of emerging concern bioconcentration biotransformation suspect screening HPLC-HRMS info:eu-repo/semantics/article 2022 ftunivpaisvasco https://doi.org/10.1016/j.envpol.2022.120016 2023-01-11T00:20:59Z The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguilla) using UHPLC-HRMS. To select the target CECs, we first carried out an environmental risk assessment of the WWTP effluent that releases directly into the Adour estuary (Bayonne, Basque Country, France). The risk quotients of every detected contaminant were calculated and three ecotoxicologically relevant contaminants were chosen to perform the exposure experiment: propranolol, diazepam, and irbesartan. An experiment of 14 days consisting of 7 days of exposure and 7 days of depuration was carried out to measure the bioconcentration of the chosen compounds. The quantitative results of the concentrations in glass eel showed that diazepam and irbesartan reached BCF approximate to 10 on day 7, but both compounds were eliminated after 7 days of depuration. On the other hand, propranolol's concentration remains constant all along with the experiment, and its presence can be detected even in the non-exposed control group, which might suggest environmental contamination. Two additional suspect screening strategies were used to identify metabolization products of the target compounds and other xenobiotics already present in wild glass eels. Only one metabolite was identified, nordiazepam, a well-known diazepam metabolite, probably due to the low metabolic rate of glass eels at this stage. The xenobiotic screening confirmed the presence of more xenobiotics in wild glass eels, prominent among them, the pharma-ceuticals exemestane, primidone, iloprost, and norethandrolone. Authors gratefully acknowledge ... Article in Journal/Newspaper Anguilla anguilla ADDI: Repositorio Institucional de la Universidad del País Vasco (UPV) Bayonne ENVELOPE(-70.983,-70.983,-68.933,-68.933) Environmental Pollution 311 120016 |
institution |
Open Polar |
collection |
ADDI: Repositorio Institucional de la Universidad del País Vasco (UPV) |
op_collection_id |
ftunivpaisvasco |
language |
English |
topic |
glass eel contaminants of emerging concern bioconcentration biotransformation suspect screening HPLC-HRMS |
spellingShingle |
glass eel contaminants of emerging concern bioconcentration biotransformation suspect screening HPLC-HRMS Álvarez Mora, Iker Bolliet, Valérie López Herguedas, Naroa Castro, Lyen Anakabe Iturriaga, Eneritz Monperrus, Mathilde Elisabeth Etxebarria Loizate, Nestor Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
topic_facet |
glass eel contaminants of emerging concern bioconcentration biotransformation suspect screening HPLC-HRMS |
description |
The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguilla) using UHPLC-HRMS. To select the target CECs, we first carried out an environmental risk assessment of the WWTP effluent that releases directly into the Adour estuary (Bayonne, Basque Country, France). The risk quotients of every detected contaminant were calculated and three ecotoxicologically relevant contaminants were chosen to perform the exposure experiment: propranolol, diazepam, and irbesartan. An experiment of 14 days consisting of 7 days of exposure and 7 days of depuration was carried out to measure the bioconcentration of the chosen compounds. The quantitative results of the concentrations in glass eel showed that diazepam and irbesartan reached BCF approximate to 10 on day 7, but both compounds were eliminated after 7 days of depuration. On the other hand, propranolol's concentration remains constant all along with the experiment, and its presence can be detected even in the non-exposed control group, which might suggest environmental contamination. Two additional suspect screening strategies were used to identify metabolization products of the target compounds and other xenobiotics already present in wild glass eels. Only one metabolite was identified, nordiazepam, a well-known diazepam metabolite, probably due to the low metabolic rate of glass eels at this stage. The xenobiotic screening confirmed the presence of more xenobiotics in wild glass eels, prominent among them, the pharma-ceuticals exemestane, primidone, iloprost, and norethandrolone. Authors gratefully acknowledge ... |
format |
Article in Journal/Newspaper |
author |
Álvarez Mora, Iker Bolliet, Valérie López Herguedas, Naroa Castro, Lyen Anakabe Iturriaga, Eneritz Monperrus, Mathilde Elisabeth Etxebarria Loizate, Nestor |
author_facet |
Álvarez Mora, Iker Bolliet, Valérie López Herguedas, Naroa Castro, Lyen Anakabe Iturriaga, Eneritz Monperrus, Mathilde Elisabeth Etxebarria Loizate, Nestor |
author_sort |
Álvarez Mora, Iker |
title |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_short |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_full |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_fullStr |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_full_unstemmed |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_sort |
prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (anguilla anguilla) from the adour estuary (basque country, france) |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://hdl.handle.net/10810/58538 https://doi.org/10.1016/j.envpol.2022.120016 |
long_lat |
ENVELOPE(-70.983,-70.983,-68.933,-68.933) |
geographic |
Bayonne |
geographic_facet |
Bayonne |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_relation |
info:eu-repo/grantAgreement/MINECO/CTM2017-84763-C3-1-R https://www.sciencedirect.com/science/article/pii/S0269749122012301?via%3Dihub Environmental Pollution 311 : (2022) // Article ID 120016 0269-7491 1873-6424 http://hdl.handle.net/10810/58538 doi:10.1016/j.envpol.2022.120016 |
op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/3.0/es/ /© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by- nc/4.0/) Atribución-NoComercial 3.0 España |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1016/j.envpol.2022.120016 |
container_title |
Environmental Pollution |
container_volume |
311 |
container_start_page |
120016 |
_version_ |
1766398740281688064 |