Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs
Meningoencephalitis of unknown origin (MUO) is one of the most common inflammatory diseases of the central nervous system (CNS). The study evaluates the possible increase and the potential role of acute phase proteins (APPs) and other inflammatory serum parameters as biomarkers predicting the short-...
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Online Access: | https://hdl.handle.net/11577/3495974 https://doi.org/10.3390/ani13162575 |
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ftunivpadovairis:oai:www.research.unipd.it:11577/3495974 2024-02-27T08:39:33+00:00 Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika 2023 https://hdl.handle.net/11577/3495974 https://doi.org/10.3390/ani13162575 eng eng MDPI info:eu-repo/semantics/altIdentifier/pmid/37627366 info:eu-repo/semantics/altIdentifier/wos/WOS:001055749300001 volume:13 issue:16 firstpage:2575 journal:ANIMALS https://hdl.handle.net/11577/3495974 doi:10.3390/ani13162575 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85168879532 info:eu-repo/semantics/openAccess Canis lupus familiari biomarker central nervous system dog inflammation inflammatory brain disease info:eu-repo/semantics/article 2023 ftunivpadovairis https://doi.org/10.3390/ani13162575 2024-01-31T17:33:59Z Meningoencephalitis of unknown origin (MUO) is one of the most common inflammatory diseases of the central nervous system (CNS). The study evaluates the possible increase and the potential role of acute phase proteins (APPs) and other inflammatory serum parameters as biomarkers predicting the short-term outcome of dogs with meningoencephalitis of unknown origin (MUO). A retrospective cohort study was designed. The APP profile and other markers of systemic inflammation of forty-eight client-owned dogs with a new diagnosis of MUO were compared between 7-day survival and non-survival dogs diagnosed with MUO. Thirty-nine (81%) dogs were alive at the end of the 7-day follow-up period, while 9 (19%) dogs died or were euthanized because of MUO. None of the 11 markers of inflammation studied were different between the survived and non-survived dogs; for this reason, none of them could be used as a predictor of the short-term outcome based on the results of the present study. This confirms that even though MUO is often associated with a severe inflammatory status of the central nervous system (CNS), this condition is probably isolated exclusively to the CNS. Article in Journal/Newspaper Canis lupus Padua Research Archive (IRIS - Università degli Studi di Padova) Animals 13 16 2575 |
institution |
Open Polar |
collection |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
op_collection_id |
ftunivpadovairis |
language |
English |
topic |
Canis lupus familiari biomarker central nervous system dog inflammation inflammatory brain disease |
spellingShingle |
Canis lupus familiari biomarker central nervous system dog inflammation inflammatory brain disease Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
topic_facet |
Canis lupus familiari biomarker central nervous system dog inflammation inflammatory brain disease |
description |
Meningoencephalitis of unknown origin (MUO) is one of the most common inflammatory diseases of the central nervous system (CNS). The study evaluates the possible increase and the potential role of acute phase proteins (APPs) and other inflammatory serum parameters as biomarkers predicting the short-term outcome of dogs with meningoencephalitis of unknown origin (MUO). A retrospective cohort study was designed. The APP profile and other markers of systemic inflammation of forty-eight client-owned dogs with a new diagnosis of MUO were compared between 7-day survival and non-survival dogs diagnosed with MUO. Thirty-nine (81%) dogs were alive at the end of the 7-day follow-up period, while 9 (19%) dogs died or were euthanized because of MUO. None of the 11 markers of inflammation studied were different between the survived and non-survived dogs; for this reason, none of them could be used as a predictor of the short-term outcome based on the results of the present study. This confirms that even though MUO is often associated with a severe inflammatory status of the central nervous system (CNS), this condition is probably isolated exclusively to the CNS. |
author2 |
Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika |
format |
Article in Journal/Newspaper |
author |
Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika |
author_facet |
Cocchetto, Aurora Zoia, Andrea Aragão, Rita Ventura, Laura Menchetti, Marika |
author_sort |
Cocchetto, Aurora |
title |
Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
title_short |
Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
title_full |
Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
title_fullStr |
Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
title_full_unstemmed |
Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs |
title_sort |
predictive value of acute phase proteins for the short-term outcome of meningoencephalitis of unknown origin in dogs |
publisher |
MDPI |
publishDate |
2023 |
url |
https://hdl.handle.net/11577/3495974 https://doi.org/10.3390/ani13162575 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/37627366 info:eu-repo/semantics/altIdentifier/wos/WOS:001055749300001 volume:13 issue:16 firstpage:2575 journal:ANIMALS https://hdl.handle.net/11577/3495974 doi:10.3390/ani13162575 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85168879532 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/ani13162575 |
container_title |
Animals |
container_volume |
13 |
container_issue |
16 |
container_start_page |
2575 |
_version_ |
1792046592806617088 |