Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry recep...
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Online Access: | http://hdl.handle.net/11577/3241951 https://doi.org/10.1111/tan.13146 http://onlinelibrary.wiley.com/doi/10.1111/tan.13146/abstract |
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ftunivpadovairis:oai:www.research.unipd.it:11577/3241951 2024-04-14T08:18:23+00:00 Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G MAZZARIOL, SANDRO Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G Mazzariol, Sandro Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. 2017 STAMPA http://hdl.handle.net/11577/3241951 https://doi.org/10.1111/tan.13146 http://onlinelibrary.wiley.com/doi/10.1111/tan.13146/abstract eng eng info:eu-repo/semantics/altIdentifier/pmid/28892257 info:eu-repo/semantics/altIdentifier/wos/WOS:000415933600003 journal:HLA http://hdl.handle.net/11577/3241951 doi:10.1111/tan.13146 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85034423447 http://onlinelibrary.wiley.com/doi/10.1111/tan.13146/abstract Phocoena phocoena Stenella coeruleoalba Cetacea MHC-DQB haplotype immunity innate polymorphism single nucleotide info:eu-repo/semantics/article 2017 ftunivpadovairis https://doi.org/10.1111/tan.13146 2024-03-21T19:29:50Z Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus-related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3, 7, 8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. Article in Journal/Newspaper Phocoena phocoena Padua Research Archive (IRIS - Università degli Studi di Padova) HLA 90 6 343 353 |
institution |
Open Polar |
collection |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
op_collection_id |
ftunivpadovairis |
language |
English |
topic |
Phocoena phocoena Stenella coeruleoalba Cetacea MHC-DQB haplotype immunity innate polymorphism single nucleotide |
spellingShingle |
Phocoena phocoena Stenella coeruleoalba Cetacea MHC-DQB haplotype immunity innate polymorphism single nucleotide Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G MAZZARIOL, SANDRO Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
topic_facet |
Phocoena phocoena Stenella coeruleoalba Cetacea MHC-DQB haplotype immunity innate polymorphism single nucleotide |
description |
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus-related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3, 7, 8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. |
author2 |
Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G Mazzariol, Sandro Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. |
format |
Article in Journal/Newspaper |
author |
Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G MAZZARIOL, SANDRO Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. |
author_facet |
Stejskalova, K Bayerova, Z Futas, J Hrazdilova, K Klumplerova, M Oppelt, J Splichalova, P Di Guardo, G MAZZARIOL, SANDRO Di Francesco, C. E Di Francesco, G Terracciano, G Paiu, R. m Ursache, T. D Modry, D Horin, P. |
author_sort |
Stejskalova, K |
title |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_short |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_fullStr |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full_unstemmed |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_sort |
candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded cetaceans |
publishDate |
2017 |
url |
http://hdl.handle.net/11577/3241951 https://doi.org/10.1111/tan.13146 http://onlinelibrary.wiley.com/doi/10.1111/tan.13146/abstract |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28892257 info:eu-repo/semantics/altIdentifier/wos/WOS:000415933600003 journal:HLA http://hdl.handle.net/11577/3241951 doi:10.1111/tan.13146 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85034423447 http://onlinelibrary.wiley.com/doi/10.1111/tan.13146/abstract |
op_doi |
https://doi.org/10.1111/tan.13146 |
container_title |
HLA |
container_volume |
90 |
container_issue |
6 |
container_start_page |
343 |
op_container_end_page |
353 |
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1796317863516045312 |