Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus).
Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that...
Published in: | Scientific Reports |
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Language: | English |
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Online Access: | http://hdl.handle.net/11577/3218370 https://doi.org/10.1038/srep41554 http://www.nature.com/articles/srep41554 |
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ftunivpadovairis:oai:www.research.unipd.it:11577/3218370 2024-04-21T07:57:52+00:00 Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). BEFFAGNA, GIORGIA CENTELLEGHE, CINZIA FRANZO, GIOVANNI MAZZARIOL, SANDRO Di Guardo, G Beffagna, Giorgia Centelleghe, Cinzia Franzo, Giovanni Di Guardo, G Mazzariol, Sandro 2017 ELETTRONICO http://hdl.handle.net/11577/3218370 https://doi.org/10.1038/srep41554 http://www.nature.com/articles/srep41554 eng eng info:eu-repo/semantics/altIdentifier/pmid/28134317 info:eu-repo/semantics/altIdentifier/wos/WOS:000392805600001 volume:7 journal:SCIENTIFIC REPORTS http://hdl.handle.net/11577/3218370 doi:10.1038/srep41554 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011269418 http://www.nature.com/articles/srep41554 info:eu-repo/semantics/openAccess info:eu-repo/semantics/article 2017 ftunivpadovairis https://doi.org/10.1038/srep41554 2024-03-28T01:56:40Z Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-'92 and the 2006-'08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells. Article in Journal/Newspaper Balaenoptera physalus Fin whale Padua Research Archive (IRIS - Università degli Studi di Padova) Scientific Reports 7 1 |
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Open Polar |
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Padua Research Archive (IRIS - Università degli Studi di Padova) |
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ftunivpadovairis |
language |
English |
description |
Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-'92 and the 2006-'08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells. |
author2 |
Beffagna, Giorgia Centelleghe, Cinzia Franzo, Giovanni Di Guardo, G Mazzariol, Sandro |
format |
Article in Journal/Newspaper |
author |
BEFFAGNA, GIORGIA CENTELLEGHE, CINZIA FRANZO, GIOVANNI MAZZARIOL, SANDRO Di Guardo, G |
spellingShingle |
BEFFAGNA, GIORGIA CENTELLEGHE, CINZIA FRANZO, GIOVANNI MAZZARIOL, SANDRO Di Guardo, G Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
author_facet |
BEFFAGNA, GIORGIA CENTELLEGHE, CINZIA FRANZO, GIOVANNI MAZZARIOL, SANDRO Di Guardo, G |
author_sort |
BEFFAGNA, GIORGIA |
title |
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
title_short |
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
title_full |
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
title_fullStr |
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
title_full_unstemmed |
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). |
title_sort |
genomic and structural investigation on dolphin morbillivirus (dmv) in mediterranean fin whales (balaenoptera physalus). |
publishDate |
2017 |
url |
http://hdl.handle.net/11577/3218370 https://doi.org/10.1038/srep41554 http://www.nature.com/articles/srep41554 |
genre |
Balaenoptera physalus Fin whale |
genre_facet |
Balaenoptera physalus Fin whale |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28134317 info:eu-repo/semantics/altIdentifier/wos/WOS:000392805600001 volume:7 journal:SCIENTIFIC REPORTS http://hdl.handle.net/11577/3218370 doi:10.1038/srep41554 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011269418 http://www.nature.com/articles/srep41554 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/srep41554 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
_version_ |
1796939305319399424 |