Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions
Transcriptomic methods are now widely used in functional genomic research. The vast amount of information received from these studies comes along with the challenge of developing a precise picture of the functional consequences and the characteristic regulatory mechanisms. Here we assess recent stud...
Published in: | Briefings in Functional Genomics |
---|---|
Main Authors: | , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2016
|
Subjects: | |
Online Access: | http://hdl.handle.net/11577/3199941 https://doi.org/10.1093/bfgp/elw024 |
id |
ftunivpadovairis:oai:www.research.unipd.it:11577/3199941 |
---|---|
record_format |
openpolar |
spelling |
ftunivpadovairis:oai:www.research.unipd.it:11577/3199941 2024-04-21T07:49:45+00:00 Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions PAPETTI, CHIARA Lucassen, Magnus Pörtner, Hans Otto Papetti, Chiara Lucassen, Magnu Pörtner, Hans Otto 2016 ELETTRONICO http://hdl.handle.net/11577/3199941 https://doi.org/10.1093/bfgp/elw024 eng eng info:eu-repo/semantics/altIdentifier/pmid/27345433 info:eu-repo/semantics/altIdentifier/wos/WOS:000385127800006 volume:15 issue:5 firstpage:365 lastpage:372 numberofpages:8 journal:BRIEFINGS IN FUNCTIONAL GENOMICS http://hdl.handle.net/11577/3199941 doi:10.1093/bfgp/elw024 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84991037866 Antarctic fish OCLTT cold adaptation ecophysiology genomic non-model organisms info:eu-repo/semantics/article 2016 ftunivpadovairis https://doi.org/10.1093/bfgp/elw024 2024-03-28T01:55:45Z Transcriptomic methods are now widely used in functional genomic research. The vast amount of information received from these studies comes along with the challenge of developing a precise picture of the functional consequences and the characteristic regulatory mechanisms. Here we assess recent studies in marine species and their adaptation to polar (and seasonal) cold and explore how they have been able to draw reliable conclusions from transcriptomic patterns on functional consequences in the organisms. Our analysis indicates that the interpretation of transcriptomic data suffers from insufficient understanding of the consequences for whole organism performance and fitness and comes with the risk of supporting only preliminary and superficial statements.We propose that the functional understanding of transcriptomic data may be improved by their tighter integration into overarching physiological concepts that support the more specific interpretation of the 'omics' data and, at the same time, can be developed further through embedding the transcriptomic phenomena observed. Such possibilities have not been fully exploited.In the context of thermal adaptation and limitation, we explore preliminary evidence that the concept of oxygen and capacity limited thermal tolerance (OCLTT) may provide sufficient complexity to guide the integration of such data and the development of associated functional hypotheses. At the same time, we identify a lack of methodological approaches linking genes and function to higher levels of integration, in terms of organism and ecosystem functioning, at temporal and geographical scales, to support more reliable conclusions and be predictive with respect to the effects of global changes. Article in Journal/Newspaper Antarc* Antarctic Padua Research Archive (IRIS - Università degli Studi di Padova) Briefings in Functional Genomics 15 5 365 372 |
institution |
Open Polar |
collection |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
op_collection_id |
ftunivpadovairis |
language |
English |
topic |
Antarctic fish OCLTT cold adaptation ecophysiology genomic non-model organisms |
spellingShingle |
Antarctic fish OCLTT cold adaptation ecophysiology genomic non-model organisms PAPETTI, CHIARA Lucassen, Magnus Pörtner, Hans Otto Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
topic_facet |
Antarctic fish OCLTT cold adaptation ecophysiology genomic non-model organisms |
description |
Transcriptomic methods are now widely used in functional genomic research. The vast amount of information received from these studies comes along with the challenge of developing a precise picture of the functional consequences and the characteristic regulatory mechanisms. Here we assess recent studies in marine species and their adaptation to polar (and seasonal) cold and explore how they have been able to draw reliable conclusions from transcriptomic patterns on functional consequences in the organisms. Our analysis indicates that the interpretation of transcriptomic data suffers from insufficient understanding of the consequences for whole organism performance and fitness and comes with the risk of supporting only preliminary and superficial statements.We propose that the functional understanding of transcriptomic data may be improved by their tighter integration into overarching physiological concepts that support the more specific interpretation of the 'omics' data and, at the same time, can be developed further through embedding the transcriptomic phenomena observed. Such possibilities have not been fully exploited.In the context of thermal adaptation and limitation, we explore preliminary evidence that the concept of oxygen and capacity limited thermal tolerance (OCLTT) may provide sufficient complexity to guide the integration of such data and the development of associated functional hypotheses. At the same time, we identify a lack of methodological approaches linking genes and function to higher levels of integration, in terms of organism and ecosystem functioning, at temporal and geographical scales, to support more reliable conclusions and be predictive with respect to the effects of global changes. |
author2 |
Papetti, Chiara Lucassen, Magnu Pörtner, Hans Otto |
format |
Article in Journal/Newspaper |
author |
PAPETTI, CHIARA Lucassen, Magnus Pörtner, Hans Otto |
author_facet |
PAPETTI, CHIARA Lucassen, Magnus Pörtner, Hans Otto |
author_sort |
PAPETTI, CHIARA |
title |
Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
title_short |
Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
title_full |
Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
title_fullStr |
Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
title_full_unstemmed |
Integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
title_sort |
integrated studies of organismal plasticity through physiological and transcriptomic approaches: examples from marine polar regions |
publishDate |
2016 |
url |
http://hdl.handle.net/11577/3199941 https://doi.org/10.1093/bfgp/elw024 |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/27345433 info:eu-repo/semantics/altIdentifier/wos/WOS:000385127800006 volume:15 issue:5 firstpage:365 lastpage:372 numberofpages:8 journal:BRIEFINGS IN FUNCTIONAL GENOMICS http://hdl.handle.net/11577/3199941 doi:10.1093/bfgp/elw024 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84991037866 |
op_doi |
https://doi.org/10.1093/bfgp/elw024 |
container_title |
Briefings in Functional Genomics |
container_volume |
15 |
container_issue |
5 |
container_start_page |
365 |
op_container_end_page |
372 |
_version_ |
1796933754563854336 |